| MONTANOVA CAPITAL, LLC |
| 0.92% | 0.03% | #6 | $50.5M | 2.0M | $1.1M | 34,549 | +2.0M+5,747.07% | Add |
| Avoro Capital Advisors LLC |
| 0.32% | — | #14 | $36.1M | 1.4M | $0 | 0 | +1.4M | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.16% | — | #18 | $32.2M | 1.3M | $0 | 0 | +1.3M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | <0.01% | #23 | $26.1M | 1.0M | $510,782 | 16,205 | +1.0M+6,331.34% | Add |
| Cormorant Asset Management, LP |
| 1.31% | 0.48% | #4 | $25.7M | 1.0M | $9.7M | 306,222 | +722,020+235.78% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | — | #19 | $18.1M | 722,020 | $0 | 0 | +722,020 | New Buy |
| Vivo Capital, LLC |
| 1.65% | 1.89% | #3 | $18.1M | 722,020 | $22.8M | 722,020 | 00.00% | Unchanged |
| Logos Global Management LP |
| 0.78% | 0.05% | #8 | $18.1M | 722,020 | $945,600 | 30,000 | +692,020+2,306.73% | Add |
| Fairmount Funds Management LLC |
| 1.19% | — | #5 | $18.1M | 722,020 | $0 | 0 | +722,020 | New Buy |
| Caligan Partners LP |
| 0.74% | 0.26% | #9 | $15.7M | 629,467 | $4.0M | 126,002 | +503,465+399.57% | Add |
| B Group, Inc. |
| 7.16% | — | #1 | $15.3M | 610,169 | $0 | 0 | +610,169 | New Buy |
| Trails Edge Capital Partners, LP |
| 2.05% | 0.9% | #2 | $12.9M | 515,335 | $3.9M | 125,000 | +390,335+312.27% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #28 | $12.4M | 494,516 | $4.2M | 133,506 | +361,010+270.41% | Add |
| Octagon Capital Advisors LP |
| 0.81% | — | #7 | $9.0M | 361,010 | $0 | 0 | +361,010 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.42% | — | #12 | $9.0M | 361,010 | $0 | 0 | +361,010 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #26 | $5.2M | 206,508 | $2.1M | 65,730 | +140,778+214.18% | Add |
| Boxer Capital Management, LLC |
| 0.34% | — | #13 | $4.5M | 180,505 | $0 | 0 | +180,505 | New Buy |
| Patient Square Capital LP |
| 0.68% | — | #10 | $4.4M | 175,050 | $0 | 0 | +175,050 | New Buy |
| Alyeska Investment Group, L.P. |
| 0.01% | — | #24 | $3.6M | 144,404 | $0 | 0 | +144,404 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.16% | — | #17 | $3.6M | 144,404 | $0 | 0 | +144,404 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | 0.01% | #22 | $3.3M | 133,643 | $823,428 | 26,124 | +107,519+411.57% | Add |
| AWM Investment Company, Inc. |
| 0.24% | — | #15 | $2.8M | 111,343 | $0 | 0 | +111,343 | New Buy |
| Richmond Investment Services, LLC |
| 0.63% | — | #11 | $2.0M | 79,731 | $0 | 0 | +79,731 | New Buy |
| Ikarian Capital, LLC |
| 0.09% | 0.02% | #20 | $884,650 | 35,386 | $200,184 | 6,351 | +29,035+457.17% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $538,525 | 21,541 | $142,754 | 4,529 | +17,012+375.62% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #29 | $510,400 | 20,416 | $1.0M | 32,041 | -11,625-36.28% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #35 | $502,906 | 20,117 | $279,646 | 8,872 | +11,245+126.75% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #38 | $433,225 | 17,329 | $95 | 10 | +17,319+173,190.00% | Add |
| Catalio Capital Management, LP |
| 0.07% | 0.1% | #21 | $367,950 | 14,718 | $463,911 | 14,718 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #39 | $365,441 | 14,616 | $299,520 | 9,501 | +5,115+53.84% | Add |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.22% | — | #16 | $354,375 | 14,175 | $0 | 0 | +14,175 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #34 | $310,300 | 12,412 | $0 | 0 | +12,412 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #36 | $307,400 | 12,296 | $0 | 0 | +12,296 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #40 | $252,875 | 10,115 | $244,280 | 7,750 | +2,365+30.52% | Add |
| XTX Topco Ltd |
| <0.01% | — | #27 | $240,200 | 9,608 | $0 | 0 | +9,608 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #37 | $157,675 | 6,307 | $198,797 | 6,307 | 00.00% | Unchanged |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #25 | $90,000 | 3,600 | $0 | 0 | +3,600 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #44 | $85,050 | 3,402 | $0 | 0 | +3,402 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #30 | $16,250 | 650 | $47,154 | 1,496 | -846-56.55% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | — | #42 | $13,000 | 509 | $0 | 0 | +509 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #43 | $2,825 | 113 | $284 | 9 | +104+1,155.56% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #45 | $929 | 40 | $804 | 32 | +8+25.00% | Add |
| Quarry LP |
| <0.01% | — | #33 | $800 | 32 | $0 | 0 | +32 | New Buy |
| Physician Wealth Advisors, Inc. |
| <0.01% | — | #31 | $700 | 28 | $0 | 0 | +28 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #41 | $100 | 4 | $126 | 4 | 00.00% | Unchanged |
