| TCG Crossover Management, LLC |
| 2.51% | 2.76% | #5 | $104.4M | 5.7M | $96.5M | 5.7M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #38 | $90.8M | 4.9M | $27.5M | 1.5M | +3.4M+220.34% | Add |
| FCPM III SERVICES B.V. |
| 10.1% | 10.17% | #1 | $75.8M | 4.1M | $73.5M | 4.1M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $63.8M | 3.5M | $14.2M | 794,759 | +2.7M+336.37% | Add |
| Venrock Adviser, LLC |
| 1.7% | 2.03% | #6 | $56.0M | 3.0M | $54.3M | 3.0M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #46 | $48.2M | 2.6M | $20.0M | 1.1M | +1.5M+133.92% | Add |
| Frazier Life Sciences Management, L.P. |
| 1.02% | 1.17% | #9 | $46.8M | 2.5M | $45.4M | 2.5M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.38% | 1.02% | #16 | $44.2M | 2.4M | $96.4M | 5.4M | -3.0M-55.56% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $38.4M | 2.1M | $25.6M | 1.4M | +651,048+45.42% | Add |
| Caligan Partners LP |
| 1.67% | 2.29% | #7 | $35.4M | 1.9M | $34.3M | 1.9M | 00.00% | Unchanged |
| Paradigm Biocapital Advisors LP |
| 0.6% | 0.64% | #11 | $32.2M | 1.8M | $31.2M | 1.8M | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 5.91% | 7.18% | #3 | $31.3M | 1.7M | $31.2M | 1.8M | -50,000-2.86% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $19.6M | 1.1M | $6.1M | 342,573 | +719,896+210.14% | Add |
| NEXTBio Capital Management LP |
| 7.53% | 8.28% | #2 | $16.4M | 889,164 | $17.8M | 999,967 | -110,803-11.08% | Reduce |
| Nantahala Capital Management, LLC |
| 0.52% | — | #13 | $15.6M | 845,000 | $0 | 0 | +845,000 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.58% | — | #12 | $12.5M | 680,626 | $0 | 0 | +680,626 | New Buy |
| Logos Global Management LP |
| 0.52% | 0.67% | #14 | $12.0M | 650,000 | $13.4M | 750,000 | -100,000-13.33% | Reduce |
| Rosalind Advisors, Inc. |
| 2.83% | 5.02% | #4 | $11.9M | 648,600 | $12.5M | 700,000 | -51,400-7.34% | Reduce |
| NAN FUNG TRINITY (HK) Ltd |
| 1.18% | — | #8 | $11.9M | 646,550 | $0 | 0 | +646,550 | New Buy |
| BRAIDWELL LP |
| 0.39% | 0.28% | #15 | $10.6M | 573,104 | $8.3M | 466,774 | +106,330+22.78% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.14% | 0.13% | #21 | $10.3M | 558,702 | $9.9M | 555,702 | +3,000+0.54% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #49 | $9.1M | 493,278 | $8.7M | 488,368 | +4,910+1.01% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $7.9M | 428,067 | $4.6M | 258,587 | +169,480+65.54% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1% | 0.91% | #10 | $7.7M | 416,417 | $5.7M | 321,917 | +94,500+29.36% | Add |
| Woodline Partners LP |
| 0.02% | — | #26 | $7.0M | 379,723 | $0 | 0 | +379,723 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #71 | $6.3M | 340,364 | $0 | 0 | +340,364 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #59 | $6.1M | 328,892 | $4.7M | 261,891 | +67,001+25.58% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #56 | $6.1M | 328,742 | $1.2M | 64,549 | +264,193+409.29% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $5.5M | 300,704 | $3.3M | 185,511 | +115,193+62.09% | Add |
| Clearline Capital LP |
| 0.31% | 0.3% | #17 | $5.3M | 285,276 | $5.8M | 326,168 | -40,892-12.54% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #76 | $3.3M | 177,739 | $2.0M | 112,892 | +64,847+57.44% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #67 | $3.0M | 160,414 | $2.7M | 148,768 | +11,646+7.83% | Add |
| Eversept Partners, LP |
| 0.14% | — | #20 | $2.8M | 149,681 | $0 | 0 | +149,681 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $2.2M | 121,398 | $396,333 | 22,216 | +99,182+446.44% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #70 | $1.8M | 97,722 | $0 | 0 | +97,722 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | 0.02% | #47 | $1.8M | 95,643 | $20.6M | 1.2M | -1.1M-91.71% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #64 | $1.7M | 94,815 | $0 | 0 | +94,815 | New Buy |
| AXIOM INVESTORS LLC /DE |
| 0.01% | 0.02% | #29 | $1.7M | 92,105 | $1.7M | 95,745 | -3,640-3.80% | Reduce |
| XTX Topco Ltd |
| 0.02% | — | #27 | $1.5M | 82,645 | $0 | 0 | +82,645 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $1.5M | 81,054 | $7.3M | 408,808 | -327,754-80.17% | Reduce |
| Jump Financial, LLC |
| 0.01% | 0.04% | #31 | $1.3M | 70,889 | $3.1M | 173,028 | -102,139-59.03% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #82 | $1.3M | 68,301 | $206,944 | 11,600 | +56,701+488.80% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #65 | $1.2M | 63,130 | $95,854 | 5,373 | +57,757+1,074.95% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $1.1M | 61,561 | $217,096 | 4,456 | +57,105+1,281.53% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #54 | $1.1M | 57,528 | $0 | 0 | +57,528 | New Buy |
| ALPS ADVISORS INC |
| <0.01% | — | #36 | $1.0M | 54,998 | $0 | 0 | +54,998 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #62 | $1.0M | 54,671 | $0 | 0 | +54,671 | New Buy |
| JOHNSON & JOHNSON |
| 0.12% | 0.15% | #22 | $989,206 | 53,732 | $958,579 | 53,732 | 00.00% | Unchanged |
| Rafferty Asset Management, LLC |
| <0.01% | <0.01% | #42 | $898,739 | 48,818 | $901,009 | 50,505 | -1,687-3.34% | Reduce |
| Walleye Capital LLC |
| <0.01% | — | #40 | $858,127 | 46,612 | $0 | 0 | +46,612 | New Buy |
