| Casdin Capital, LLC |
| 3.66% | 6.18% | #1 | $73.0M | 88.8M | $81.6M | 88.8M | 00.00% | Unchanged |
| VIKING GLOBAL INVESTORS LP |
| 0.14% | 0.15% | #9 | $48.3M | 58.7M | $53.9M | 58.7M | 00.00% | Unchanged |
| MAK CAPITAL ONE LLC |
| 3.32% | 3.55% | #2 | $23.7M | 28.8M | $24.1M | 26.2M | +2.6M+10.09% | Add |
| Long Focus Capital Management, LLC |
| 0.5% | 0.39% | #7 | $19.3M | 23.5M | $14.7M | 16.0M | +7.5M+46.73% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $10.1M | 12.3M | $11.8M | 12.8M | -563,072-4.39% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $6.8M | 8.3M | $22.8M | 24.8M | -16.5M-66.66% | Reduce |
| Hollow Brook Wealth Management LLC |
| 0.9% | 1.33% | #4 | $4.5M | 5.5M | $5.2M | 5.7M | -150,000-2.65% | Reduce |
| Neuberger Berman Group LLC |
| <0.01% | <0.01% | #29 | $4.0M | 5.0M | $4.3M | 4.7M | +301,035+6.46% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #25 | $4.0M | 4.8M | $647,561 | 704,407 | +4.1M+584.33% | Add |
| ROYCE & ASSOCIATES LP |
| 0.03% | 0.03% | #15 | $3.7M | 4.5M | $2.8M | 3.0M | +1.5M+50.57% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #64 | $3.2M | 3.9M | $6.7M | 7.3M | -3.4M-46.54% | Reduce |
| Tikvah Management LLC |
| 0.89% | 1.01% | #5 | $2.9M | 3.6M | $3.3M | 3.6M | -94-0.00% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $2.9M | 3.5M | $1.9M | 2.1M | +1.4M+67.11% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $2.3M | 2.8M | $8.3M | 6.4M | -3.5M-55.44% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #37 | $2.3M | 2.8M | $183,018 | 199,084 | +2.6M+1,315.50% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | — | #63 | $2.1M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Peapod Lane Capital LLC |
| 1.34% | 1.53% | #3 | $2.0M | 2.4M | $1.9M | 2.0M | +382,947+18.88% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $2.0M | 2.4M | $1.2M | 1.3M | +1.1M+87.38% | Add |
| Mink Brook Asset Management LLC |
| 0.8% | — | #6 | $1.8M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Sone Capital Management, LLC |
| 0.13% | 0.14% | #10 | $1.8M | 2.1M | $1.6M | 1.8M | +366,850+20.76% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #46 | $1.6M | 2.0M | $0 | 0 | +2.0M | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #53 | $1.6M | 1.9M | $1.8M | 1.9M | -27,591-1.44% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $1.4M | 1.8M | $2.2M | 2.4M | -655,661-27.15% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | — | #21 | $1.3M | 1.6M | $0 | 0 | +1.6M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #94 | $1.3M | 1.5M | $6.0M | 6.6M | -5.0M-76.47% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #51 | $1.1M | 1.4M | $857,798 | 933,098 | +425,920+45.65% | Add |
| LOEWS CORP |
| 0.01% | — | #18 | $1.0M | 1.3M | $0 | 0 | +1.3M | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.06% | 0.02% | #11 | $977,106 | 1.2M | $325,000 | 353,471 | +834,211+236.01% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #36 | $816,166 | 992,058 | $0 | 0 | +992,058 | New Buy |
| STALEY CAPITAL ADVISERS INC |
| 0.03% | 0.03% | #16 | $658,160 | 800,000 | $581,358 | 632,392 | +167,608+26.50% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #77 | $651,188 | 791,526 | $2.3M | 2.5M | -1.7M-67.75% | Reduce |
| Man Group plc |
| <0.01% | — | #40 | $611,096 | 742,793 | $0 | 0 | +742,793 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #47 | $582,464 | 707,991 | $41,112 | 44,721 | +663,270+1,483.13% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #101 | $555,305 | 674,733 | $2.2M | 2.4M | -1.7M-71.82% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #98 | $403,215 | 490,296 | $140,968 | 153,343 | +336,953+219.74% | Add |
| Jain Global LLC |
| <0.01% | — | #32 | $384,462 | 467,317 | $0 | 0 | +467,317 | New Buy |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #48 | $352,535 | 428,510 | $484,846 | 527,408 | -98,898-18.75% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #90 | $350,578 | 425,977 | $280,407 | 305,122 | +120,855+39.61% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #61 | $339,189 | 412,288 | $407,051 | 442,784 | -30,496-6.89% | Reduce |
| Amova Asset Management Americas, Inc. |
| <0.01% | 0.01% | #22 | $338,076 | 412,288 | $407,361 | 442,784 | -30,496-6.89% | Reduce |
| Intellectus Partners, LLC |
| 0.06% | 0.08% | #12 | $332,948 | 404,702 | $372,043 | 404,702 | 00.00% | Unchanged |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #57 | $292,537 | 355,581 | $50,094 | 54,491 | +301,090+552.55% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #55 | $270,301 | 328,553 | $288,771 | 314,120 | +14,433+4.59% | Add |
| OPPENHEIMER & CO INC |
| <0.01% | <0.01% | #28 | $268,694 | 326,600 | $322,573 | 350,890 | -24,290-6.92% | Reduce |
| Marquette Asset Management, LLC |
| 0.03% | — | #13 | $267,662 | 325,345 | $0 | 0 | +325,345 | New Buy |
| JOHNSON & JOHNSON |
| 0.03% | 0.04% | #14 | $256,655 | 311,967 | $286,791 | 311,967 | 00.00% | Unchanged |
| Susquehanna Portfolio Strategies, LLC |
| <0.01% | — | #24 | $239,828 | 291,513 | $0 | 0 | +291,513 | New Buy |
| XTX Topco Ltd |
| <0.01% | 0.01% | #27 | $228,567 | 277,826 | $302,384 | 328,929 | -51,103-15.54% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #58 | $228,196 | 277,375 | $0 | 0 | +277,375 | New Buy |
| HSBC HOLDINGS PLC |
| <0.01% | — | #74 | $218,766 | 271,523 | $0 | 0 | +271,523 | New Buy |
