| PRIMECAP MANAGEMENT CO/CA/ |
| <0.01% | <0.01% | #17 | $6.0M | 4.6M | $6.1M | 4.7M | -112,660-2.38% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #40 | $3.8M | 2.9M | $5.9M | 3.6M | -697,755-19.27% | Reduce |
| Soleus Capital Management, L.P. |
| 0.12% | 0.15% | #4 | $3.6M | 2.8M | $3.6M | 2.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $2.1M | 1.6M | $2.1M | 1.6M | -4,045-0.25% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.01% | — | #15 | $1.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Almitas Capital LLC |
| 0.32% | — | #1 | $1.4M | 1.1M | $0 | 0 | +1.1M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #77 | $1.1M | 882,490 | $3.4M | 2.7M | -1.8M-66.84% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #49 | $1.1M | 882,031 | $191,655 | 148,570 | +733,461+493.68% | Add |
| Stonepine Capital Management, LLC |
| 0.16% | 0.4% | #3 | $1.1M | 815,436 | $991,092 | 768,288 | +47,148+6.14% | Add |
| BRAIDWELL LP |
| 0.04% | 0.03% | #9 | $978,303 | 752,541 | $970,778 | 752,541 | 00.00% | Unchanged |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $968,453 | 744,963 | $461,276 | 357,578 | +387,385+108.34% | Add |
| Parkman Healthcare Partners LLC |
| 0.09% | 0.1% | #6 | $840,533 | 646,564 | $974,770 | 755,636 | -109,072-14.43% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $588,714 | 452,684 | $1.2M | 944,492 | -491,808-52.07% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #27 | $552,643 | 425,110 | $413,187 | 320,300 | +104,810+32.72% | Add |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.03% | #10 | $525,846 | 404,497 | $483,101 | 374,497 | +30,000+8.01% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #42 | $523,011 | 402,316 | $1.5M | 1.2M | -761,362-65.43% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $522,735 | 402,104 | $86,571 | 67,109 | +334,995+499.18% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #39 | $425,787 | 327,528 | $432,246 | 335,074 | -7,546-2.25% | Reduce |
| Jefferies Financial Group Inc. |
| <0.01% | <0.01% | #18 | $370,643 | 285,110 | $367,792 | 285,110 | 00.00% | Unchanged |
| CFM WEALTH PARTNERS LLC |
| 0.04% | 0.05% | #7 | $343,251 | 264,039 | $340,610 | 264,039 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #55 | $325,664 | 250,511 | $362,810 | 281,248 | -30,737-10.93% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #37 | $299,959 | 230,738 | $0 | 0 | +230,738 | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $290,083 | 223,141 | $212,000 | 166,341 | +56,800+34.15% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #51 | $272,423 | 209,556 | $0 | 0 | +209,556 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #66 | $265,269 | 204,053 | $270,514 | 209,701 | -5,648-2.69% | Reduce |
| Birchview Capital, LP |
| 0.12% | 0.18% | #5 | $260,706 | 200,543 | $322,785 | 250,221 | -49,678-19.85% | Reduce |
| Centiva Capital, LP |
| <0.01% | <0.01% | #19 | $260,124 | 200,095 | $198,508 | 153,882 | +46,213+30.03% | Add |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.2% | 0.19% | #2 | $260,000 | 200,000 | $203,175 | 157,500 | +42,500+26.98% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #46 | $249,092 | 193,846 | $18,458 | 14,090 | +179,756+1,275.77% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #87 | $248,951 | 191,501 | $1.0M | 809,116 | -617,615-76.33% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #34 | $238,625 | 183,558 | $106,415 | 82,492 | +101,066+122.52% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $194,705 | 149,773 | $220,937 | 171,269 | -21,496-12.55% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.01% | #14 | $177,004 | 136,157 | $177,000 | 137,488 | -1,331-0.97% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $175,946 | 135,343 | $288,251 | 223,450 | -88,107-39.43% | Reduce |
| XTX Topco Ltd |
| <0.01% | <0.01% | #20 | $153,448 | 118,037 | $103,304 | 80,081 | +37,956+47.40% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| <0.01% | <0.01% | #30 | $143,000 | 110,000 | $141,900 | 110,000 | 00.00% | Unchanged |
| HRT FINANCIAL LP |
| <0.01% | — | #35 | $140,683 | 108,218 | $0 | 0 | +108,218 | New Buy |
| BANK OF MONTREAL /CAN/ |
| <0.01% | — | #63 | $137,745 | 105,958 | $0 | 0 | +105,958 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $135,355 | 104,119 | $457,529 | 354,674 | -250,555-70.64% | Reduce |
| Redhawk Wealth Advisors, Inc. |
| 0.01% | <0.01% | #13 | $129,542 | 99,648 | $44,763 | 34,700 | +64,948+187.17% | Add |
| ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #21 | $127,832 | 98,332 | $110,000 | 85,362 | +12,970+15.19% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #72 | $127,243 | 97,791 | $182,656 | 141,920 | -44,129-31.09% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #53 | $112,548 | 86,575 | $88,509 | 68,612 | +17,963+26.18% | Add |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #31 | $89,906 | 69,158 | $27,847 | 21,587 | +47,571+220.37% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #28 | $83,083 | 63,910 | $0 | 0 | +63,910 | New Buy |
| Engineers Gate Manager LP |
| <0.01% | <0.01% | #26 | $81,366 | 62,589 | $72,435 | 56,151 | +6,438+11.47% | Add |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | <0.01% | #48 | $79,732 | 61,332 | $62,909 | 48,767 | +12,565+25.77% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $79,300 | 61,000 | $78,690 | 61,000 | 00.00% | Unchanged |
| Berger Financial Group, Inc |
| <0.01% | <0.01% | #16 | $70,200 | 54,000 | $69,660 | 54,000 | 00.00% | Unchanged |
| BRIGHTON JONES LLC |
| <0.01% | — | #24 | $69,201 | 53,231 | $0 | 0 | +53,231 | New Buy |
