| Soleus Capital Management, L.P. |
| 0.94% | — | #7 | $27.3M | 13.1M | $0 | 0 | +13.1M | New Buy |
| B Group, Inc. |
| 11.2% | 14.81% | #1 | $23.9M | 11.4M | $20.0M | 11.4M | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #47 | $23.2M | 11.1M | $15.2M | 8.7M | +2.4M+27.21% | Add |
| Jupiter Topco LLC |
| 0.01% | — | #39 | $22.4M | 10.7M | $0 | 0 | +10.7M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $21.8M | 10.4M | $3.3M | 1.9M | +8.6M+456.23% | Add |
| Octagon Capital Advisors LP |
| 1.93% | 1.99% | #5 | $21.5M | 10.3M | $18.0M | 10.3M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.26% | 0.31% | #16 | $17.6M | 8.4M | $15.6M | 8.9M | -503,084-5.63% | Reduce |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.13% | 0.13% | #20 | $14.9M | 7.1M | $12.5M | 7.1M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #51 | $12.1M | 5.8M | $10.1M | 5.8M | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #36 | $11.0M | 5.3M | $720,601 | 411,772 | +4.8M+1,175.80% | Add |
| Boxer Capital Management, LLC |
| 0.76% | 1.1% | #11 | $10.0M | 4.8M | $8.4M | 4.8M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #32 | $9.4M | 4.5M | $7.9M | 4.5M | 00.00% | Unchanged |
| Eversept Partners, LP |
| 0.45% | 0.46% | #13 | $8.7M | 4.2M | $8.7M | 5.0M | -804,714-16.13% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $7.9M | 3.8M | $2.7M | 1.5M | +2.2M+143.20% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #53 | $7.7M | 3.7M | $5.1M | 2.9M | +799,025+27.51% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $7.5M | 3.6M | $9.4M | 5.4M | -1.8M-33.42% | Reduce |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #38 | $6.6M | 3.1M | $5.5M | 3.1M | 00.00% | Unchanged |
| Squadron Capital Management LLC |
| 1.95% | 1.92% | #4 | $6.3M | 3.0M | $5.3M | 3.0M | 00.00% | Unchanged |
| Propel Bio Management, LLC |
| 2.82% | 1.26% | #2 | $5.4M | 2.6M | $2.0M | 1.1M | +1.5M+131.60% | Add |
| Vestal Point Capital, LP |
| 0.12% | 0.12% | #22 | $5.2M | 2.5M | $4.4M | 2.5M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #84 | $5.2M | 2.5M | $1.1M | 636,197 | +1.8M+289.13% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #74 | $5.2M | 2.5M | $7,409 | 8,618 | +2.5M+28,608.16% | Add |
| ORBIMED ADVISORS LLC |
| 0.09% | 0.08% | #24 | $4.9M | 2.3M | $4.1M | 2.3M | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 0.9% | 1.37% | #8 | $4.8M | 2.3M | $6.0M | 3.4M | -1.1M-32.91% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.62% | 0.48% | #12 | $4.7M | 2.3M | $3.0M | 1.7M | +523,635+30.21% | Add |
| HighVista Strategies LLC |
| 0.97% | 0.98% | #6 | $4.2M | 2.0M | $3.5M | 2.0M | +11,601+0.57% | Add |
| Siren, L.L.C. |
| 0.08% | — | #25 | $4.2M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Artia Global Partners LP |
| 0.77% | 0.7% | #10 | $4.2M | 2.0M | $3.5M | 2.0M | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.01% | <0.01% | #42 | $4.0M | 1.9M | $1.2M | 662,900 | +1.2M+188.16% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.01% | #45 | $3.9M | 1.9M | $5.7M | 3.3M | -1.4M-42.65% | Reduce |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.89% | 0.54% | #9 | $3.6M | 1.7M | $2.2M | 1.2M | +499,452+40.56% | Add |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.23% | #19 | $3.6M | 1.7M | $4.0M | 2.3M | -538,183-23.76% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $3.6M | 1.7M | $2.5M | 1.4M | +293,509+20.54% | Add |
| Ally Bridge Group (NY) LLC |
| 2.27% | — | #3 | $2.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #73 | $2.5M | 1.2M | $491,138 | 280,650 | +916,970+326.73% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #50 | $2.4M | 1.1M | $2.5M | 1.5M | -329,600-22.66% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #76 | $2.1M | 1.0M | $24,976 | 14,272 | +1.0M+7,024.79% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #88 | $2.1M | 994,095 | $0 | 0 | +994,095 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #65 | $2.0M | 969,457 | $0 | 0 | +969,457 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $2.0M | 934,155 | $3.7M | 2.1M | -1.2M-55.59% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $1.9M | 885,912 | $1.2M | 659,289 | +226,623+34.37% | Add |
| Ikarian Capital, LLC |
| 0.17% | 0.04% | #18 | $1.6M | 750,000 | $481,212 | 274,978 | +475,022+172.75% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #79 | $1.5M | 737,307 | $2.0M | 1.2M | -429,644-36.82% | Reduce |
| BIT Capital GmbH |
| 0.04% | 0.01% | #28 | $1.2M | 574,000 | $271,250 | 155,000 | +419,000+270.32% | Add |
| Simplify Asset Management Inc. |
| 0.01% | 0.01% | #33 | $941,635 | 450,543 | $612,500 | 350,000 | +100,543+28.73% | Add |
| Creek Drive Management Group LLC |
| 0.45% | 0.22% | #14 | $919,600 | 440,000 | $945,000 | 540,000 | -100,000-18.52% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | <0.01% | #35 | $913,616 | 437,137 | $296,884 | 169,648 | +267,489+157.67% | Add |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.06% | 0.04% | #26 | $912,758 | 436,726 | $568,784 | 325,019 | +111,707+34.37% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $909,114 | 434,983 | $133,000 | 76,000 | +358,983+472.35% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #60 | $833,471 | 398,790 | $4.8M | 2.8M | -2.4M-85.52% | Reduce |
