| Jupiter Topco LLC |
| 0.01% | — | #13 | $27.6M | 6.3M | $0 | 0 | +6.3M | New Buy |
| 5AM Venture Management, LLC |
| 8.91% | 7.19% | #1 | $25.6M | 5.9M | $25.9M | 5.9M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #17 | $21.4M | 4.9M | $21.8M | 4.9M | -29,093-0.59% | Reduce |
| Vivo Capital, LLC |
| 1.69% | 1.56% | #4 | $18.6M | 4.2M | $18.7M | 4.2M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #11 | $11.3M | 2.6M | $11.6M | 2.6M | -56,713-2.15% | Reduce |
| a16z Capital Management, L.L.C. |
| 0.75% | 0.73% | #7 | $9.4M | 2.1M | $9.4M | 2.1M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #12 | $8.6M | 2.0M | $8.6M | 2.0M | 00.00% | Unchanged |
| Trails Edge Capital Partners, LP |
| 1.34% | 1.96% | #5 | $8.4M | 1.9M | $8.6M | 1.9M | -6,626-0.34% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #32 | $7.2M | 1.6M | $2.0M | 456,371 | +1.2M+260.26% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #28 | $6.7M | 1.5M | $6.8M | 1.5M | -1,279-0.08% | Reduce |
| Enavate Sciences GP, LLC |
| 1.8% | 2.75% | #3 | $6.2M | 1.4M | $9.7M | 2.2M | -765,379-34.93% | Reduce |
| Stonepine Capital Management, LLC |
| 0.93% | 2.45% | #6 | $6.1M | 1.4M | $6.1M | 1.4M | 00.00% | Unchanged |
| HARBOURVEST PARTNERS LLC |
| 3.27% | 5.56% | #2 | $5.6M | 1.3M | $5.6M | 1.3M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #27 | $3.5M | 795,651 | $1.7M | 382,821 | +412,830+107.84% | Add |
| SummitTX Capital, L.P. |
| 0.08% | 0.05% | #10 | $3.2M | 725,160 | $1.5M | 339,521 | +385,639+113.58% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.3% | 0.29% | #8 | $2.9M | 653,594 | $2.9M | 653,594 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #41 | $1.6M | 362,300 | $647,829 | 146,900 | +215,400+146.63% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $1.1M | 248,673 | $311,637 | 70,666 | +178,007+251.90% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #33 | $1.1M | 241,393 | $345,501 | 78,345 | +163,048+208.12% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #23 | $987,943 | 226,074 | $860,007 | 195,013 | +31,061+15.93% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #43 | $964,533 | 220,717 | $0 | 0 | +220,717 | New Buy |
| Birchview Capital, LP |
| 0.24% | — | #9 | $524,400 | 120,000 | $0 | 0 | +120,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $457,146 | 104,610 | $480,139 | 108,875 | -4,265-3.92% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #39 | $422,404 | 96,660 | $88,200 | 20,000 | +76,660+383.30% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #38 | $364,550 | 83,421 | $82,546 | 18,718 | +64,703+345.67% | Add |
| VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #25 | $360,307 | 82,450 | $363,605 | 82,450 | 00.00% | Unchanged |
| CANTOR FITZGERALD, L. P. |
| <0.01% | — | #15 | $233,795 | 53,500 | $0 | 0 | +53,500 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $191,856 | 43,903 | $378,898 | 85,918 | -42,015-48.90% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #42 | $183,750 | 42,048 | $0 | 0 | +42,048 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #45 | $138,044 | 31,589 | $0 | 0 | +31,589 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #14 | $135,217 | 30,942 | $0 | 0 | +30,942 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #48 | $126,109 | 28,858 | $0 | 0 | +28,858 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #50 | $115,049 | 26,327 | $0 | 0 | +26,327 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #16 | $109,250 | 25,000 | $110,250 | 25,000 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | — | #34 | $105,867 | 24,227 | $0 | 0 | +24,227 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #53 | $97,997 | 22,425 | $0 | 0 | +22,425 | New Buy |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #31 | $86,963 | 19,900 | $0 | 0 | +19,900 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | <0.01% | #22 | $81,549 | 18,661 | $213,934 | 48,511 | -29,850-61.53% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #56 | $77,668 | 17,773 | $137,574 | 31,196 | -13,423-43.03% | Reduce |
| Quadrature Capital Ltd |
| <0.01% | — | #18 | $68,945 | 15,777 | $0 | 0 | +15,777 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #47 | $65,441 | 14,975 | $43,602 | 9,887 | +5,088+51.46% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #35 | $63,662 | 14,568 | $0 | 0 | +14,568 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #40 | $62,015 | 14,191 | $0 | 0 | +14,191 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #57 | $58,235 | 13,116 | $0 | 0 | +13,116 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #46 | $50,758 | 11,615 | $51,222 | 11,615 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $50,365 | 11,525 | $40,047 | 9,081 | +2,444+26.91% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #59 | $50,085 | 11,461 | $9 | 3 | +11,458+381,933.33% | Add |
| Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #19 | $48,581 | 11,117 | $0 | 0 | +11,117 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $42,254 | 9,669 | $159 | 36 | +9,633+26,758.33% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #55 | $31,009 | 7,096 | $152,997 | 34,693 | -27,597-79.55% | Reduce |
