| Jupiter Topco LLC |
| 0.01% | — | #18 | $20.7M | 6.5M | $0 | 0 | +6.5M | New Buy |
| Decheng Capital LLC |
| 1.94% | 1.34% | #1 | $14.2M | 4.4M | $8.9M | 4.4M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.59% | 0.13% | #4 | $13.1M | 4.1M | $2.5M | 1.2M | +2.9M+234.34% | Add |
| ADAR1 Capital Management, LLC |
| 0.55% | 0.44% | #5 | $12.0M | 3.8M | $7.5M | 3.7M | +31,910+0.86% | Add |
| Aberdeen Group plc |
| 0.02% | 0.01% | #15 | $11.6M | 3.6M | $6.7M | 3.4M | +278,822+8.32% | Add |
| Woodline Partners LP |
| 0.03% | 0.03% | #13 | $11.2M | 3.5M | $7.0M | 3.5M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.09% | 0.07% | #11 | $9.9M | 3.1M | $6.2M | 3.1M | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 0.92% | — | #3 | $6.5M | 2.0M | $0 | 0 | +2.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $5.8M | 1.8M | $3.6M | 1.8M | +38,340+2.15% | Add |
| Eversept Partners, LP |
| 0.25% | 0.16% | #7 | $4.9M | 1.5M | $3.0M | 1.5M | +21,831+1.46% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.02% | #19 | $4.4M | 1.4M | $10.7M | 5.3M | -3.9M-73.91% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #25 | $2.0M | 637,617 | $1.3M | 656,964 | -19,347-2.94% | Reduce |
| Exome Asset Management LLC |
| 1.09% | — | #2 | $1.8M | 552,956 | $0 | 0 | +552,956 | New Buy |
| DG Capital Management, LLC |
| 0.31% | — | #6 | $1.5M | 463,396 | $0 | 0 | +463,396 | New Buy |
| DIADEMA PARTNERS LP |
| 0.16% | 0.15% | #8 | $1.3M | 400,282 | $867,688 | 433,844 | -33,562-7.74% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #41 | $1.2M | 381,175 | $757,975 | 378,813 | +2,362+0.62% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #28 | $1.1M | 344,409 | $3.3M | 1.6M | -1.3M-78.98% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #27 | $1.0M | 320,100 | $40,200 | 20,100 | +300,000+1,492.54% | Add |
| Ikarian Capital, LLC |
| 0.1% | 0.05% | #9 | $971,376 | 303,555 | $607,110 | 303,555 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $913,308 | 285,409 | $255,704 | 127,852 | +157,557+123.23% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | <0.01% | #16 | $909,856 | 284,330 | $186,422 | 93,211 | +191,119+205.04% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #33 | $661,930 | 206,853 | $492,346 | 246,173 | -39,320-15.97% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #42 | $656,995 | 205,311 | $462,070 | 231,035 | -25,724-11.13% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $610,592 | 190,810 | $379,060 | 189,530 | +1,280+0.68% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #43 | $595,244 | 186,014 | $442,482 | 221,241 | -35,227-15.92% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #51 | $556,992 | 174,060 | $348,120 | 174,060 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #46 | $371,398 | 116,062 | $379,866 | 189,933 | -73,871-38.89% | Reduce |
| CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #21 | $348,998 | 109,062 | $525,286 | 262,643 | -153,581-58.48% | Reduce |
| Persistent Asset Partners Ltd |
| 0.1% | 0.08% | #10 | $326,432 | 102,010 | $220,234 | 110,117 | -8,107-7.36% | Reduce |
| Soleus Capital Management, L.P. |
| 0.01% | — | #17 | $288,000 | 90,000 | $0 | 0 | +90,000 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #40 | $240,832 | 75,260 | $0 | 0 | +75,260 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #49 | $228,989 | 71,559 | $140,316 | 70,158 | +1,401+2.00% | Add |
| AlphaCore Capital LLC |
| <0.01% | <0.01% | #22 | $167,504 | 52,345 | $104,690 | 52,345 | 00.00% | Unchanged |
| ExodusPoint Capital Management, LP |
| <0.01% | — | #29 | $141,405 | 44,189 | $0 | 0 | +44,189 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #44 | $137,082 | 42,838 | $0 | 0 | +42,838 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #26 | $125,642 | 39,263 | $206,210 | 103,105 | -63,842-61.92% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #39 | $119,680 | 37,400 | $429,000 | 214,500 | -177,100-82.56% | Reduce |
| Invesco Ltd. |
| <0.01% | — | #55 | $116,131 | 36,291 | $0 | 0 | +36,291 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #50 | $112,000 | 35,000 | $0 | 0 | +35,000 | New Buy |
| Jefferies Financial Group Inc. |
| <0.01% | — | #31 | $109,120 | 34,100 | $0 | 0 | +34,100 | New Buy |
| High Net Worth Advisory Group LLC |
| 0.02% | — | #14 | $107,200 | 33,500 | $0 | 0 | +33,500 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #48 | $104,624 | 32,695 | $2 | 1 | +32,694+3,269,400.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #58 | $95,639 | 29,887 | $14,422 | 10,085 | +19,802+196.35% | Add |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #30 | $91,696 | 28,655 | $57,520 | 28,760 | -105-0.37% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #35 | $86,330 | 26,978 | $0 | 0 | +26,978 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #47 | $82,864 | 25,895 | $0 | 0 | +25,895 | New Buy |
| China Universal Asset Management Co., Ltd. |
| <0.01% | — | #20 | $80,000 | 25,000 | $0 | 0 | +25,000 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $73,382 | 22,932 | $27,480 | 13,740 | +9,192+66.90% | Add |
| Chung Wu Investment Group, LLC |
| 0.03% | — | #12 | $52,800 | 16,500 | $0 | 0 | +16,500 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #56 | $49,066 | 15,333 | $30,666 | 15,333 | 00.00% | Unchanged |
