| Column Group LLC |
| 56.46% | 55.45% | #1 | $49.7M | 1.9M | $55.8M | 1.9M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 0.92% | 1.23% | #8 | $38.2M | 1.5M | $42.9M | 1.5M | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 2.03% | 2.93% | #6 | $27.0M | 1.1M | $22.3M | 766,318 | +339,365+44.29% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #22 | $17.7M | 683,079 | $21.3M | 731,138 | -48,059-6.57% | Reduce |
| Point72 Asset Management, L.P. |
| 0.02% | — | #20 | $17.2M | 664,272 | $0 | 0 | +664,272 | New Buy |
| Venrock Adviser, LLC |
| 0.5% | 0.69% | #11 | $16.4M | 632,931 | $18.4M | 632,931 | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 1.96% | 2.48% | #7 | $13.8M | 602,798 | $13.5M | 525,639 | +77,159+14.68% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.2% | 0.13% | #14 | $13.1M | 503,985 | $6.7M | 229,393 | +274,592+119.70% | Add |
| Spruce Street Capital LP |
| 2.2% | 3.03% | #5 | $11.2M | 432,040 | $12.6M | 432,040 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $10.2M | 394,864 | $811,299 | 27,851 | +367,013+1,317.77% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #40 | $10.2M | 392,550 | $4.9M | 169,092 | +223,458+132.15% | Add |
| BRAIDWELL LP |
| 0.38% | 0.38% | #12 | $10.1M | 390,753 | $11.5M | 396,100 | -5,347-1.35% | Reduce |
| Kalehua Capital Management LLC |
| 7.16% | 7.94% | #2 | $10.0M | 385,178 | $11.2M | 385,178 | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.18% | 0.28% | #15 | $7.9M | 304,669 | $9.9M | 338,611 | -33,942-10.02% | Reduce |
| 5AM Venture Management, LLC |
| 2.44% | 3.13% | #4 | $7.0M | 271,250 | $11.3M | 387,500 | -116,250-30.00% | Reduce |
| Vivo Capital, LLC |
| 0.62% | 0.63% | #9 | $6.7M | 260,000 | $7.6M | 260,000 | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #21 | $5.3M | 205,032 | $5.9M | 203,888 | +1,144+0.56% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #37 | $5.2M | 201,652 | $1.9M | 65,849 | +135,803+206.23% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 3.14% | 3.55% | #3 | $4.5M | 173,395 | $5.0M | 172,847 | +548+0.32% | Add |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA |
| 0.08% | 0.11% | #17 | $3.5M | 133,207 | $3.0M | 133,207 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #47 | $3.5M | 133,084 | $807,658 | 27,726 | +105,358+380.00% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #39 | $2.9M | 113,531 | $753,040 | 25,851 | +87,680+339.17% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #26 | $2.3M | 88,653 | $2.6M | 88,653 | 00.00% | Unchanged |
| Euclidean Capital LLC |
| 0.52% | 0.65% | #10 | $2.3M | 87,696 | $2.6M | 87,696 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #28 | $1.8M | 71,119 | $1.2M | 39,482 | +31,637+80.13% | Add |
| Stonepine Capital Management, LLC |
| 0.27% | 0.39% | #13 | $1.8M | 68,001 | $961,436 | 33,005 | +34,996+106.03% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #41 | $1.7M | 63,609 | $357,279 | 12,265 | +51,344+418.62% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $1.5M | 59,575 | $1.0M | 35,390 | +24,185+68.34% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.06% | 0.04% | #19 | $1.4M | 55,123 | $1.6M | 55,123 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #54 | $1.3M | 51,026 | $0 | 0 | +51,026 | New Buy |
| Eversept Partners, LP |
| 0.06% | 0.09% | #18 | $1.2M | 47,777 | $1.7M | 58,624 | -10,847-18.50% | Reduce |
| Walleye Capital LLC |
| <0.01% | — | #25 | $1.0M | 38,832 | $0 | 0 | +38,832 | New Buy |
| Ellsworth Advisors, LLC |
| 0.14% | — | #16 | $855,977 | 39,283 | $0 | 0 | +39,283 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #57 | $812,105 | 31,295 | $0 | 0 | +31,295 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #49 | $758,493 | 29,229 | $618,925 | 21,247 | +7,982+37.57% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #51 | $719,879 | 27,741 | $633,000 | 21,715 | +6,026+27.75% | Add |
| FRED ALGER MANAGEMENT, LLC |
| <0.01% | 0.01% | #27 | $622,904 | 24,004 | $2.1M | 71,697 | -47,693-66.52% | Reduce |
| XTX Topco Ltd |
| 0.01% | — | #24 | $436,687 | 16,828 | $0 | 0 | +16,828 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #55 | $422,907 | 16,297 | $0 | 0 | +16,297 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #52 | $399,085 | 15,379 | $0 | 0 | +15,379 | New Buy |
| LMR Partners LLP |
| <0.01% | <0.01% | #29 | $351,804 | 13,557 | $686,215 | 23,557 | -10,000-42.45% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $321,105 | 12,374 | $1.4M | 49,126 | -36,752-74.81% | Reduce |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #30 | $264,379 | 10,188 | $296,776 | 10,188 | 00.00% | Unchanged |
| Fisher Asset Management, LLC |
| <0.01% | — | #50 | $255,348 | 9,840 | $0 | 0 | +9,840 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #53 | $253,791 | 9,780 | $0 | 0 | +9,780 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $210,965 | 8,130 | $0 | 0 | +8,130 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #48 | $208,353 | 8,029 | $213,377 | 7,325 | +704+9.61% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #56 | $189,487 | 7,302 | $0 | 0 | +7,302 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #64 | $185,569 | 7,151 | $447,934 | 34,764 | -27,613-79.43% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #61 | $173,813 | 6,698 | $0 | 0 | +6,698 | New Buy |
