| TCG Crossover Management, LLC |
| 1.63% | — | #5 | $67.7M | 9.5M | $0 | 0 | +9.5M | New Buy |
| MONTANOVA CAPITAL, LLC |
| 0.94% | 0.75% | #12 | $51.2M | 7.2M | $29.3M | 4.4M | +2.8M+64.79% | Add |
| Frazier Life Sciences Management, L.P. |
| 1.1% | 0.88% | #10 | $50.4M | 7.1M | $34.1M | 5.1M | +2.0M+39.22% | Add |
| Long Focus Capital Management, LLC |
| 0.94% | 0.81% | #11 | $36.3M | 5.1M | $30.9M | 4.6M | +500,000+10.82% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #64 | $33.4M | 4.7M | $24.0M | 3.6M | +1.1M+31.26% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.05% | #30 | $32.9M | 4.6M | $32.7M | 4.9M | -241,125-4.94% | Reduce |
| Caligan Partners LP |
| 1.44% | 0.1% | #9 | $30.5M | 4.3M | $1.5M | 229,864 | +4.1M+1,769.91% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $29.1M | 4.1M | $15.0M | 2.2M | +1.9M+82.74% | Add |
| FCPM III SERVICES B.V. |
| 3.84% | — | #2 | $28.8M | 4.1M | $0 | 0 | +4.1M | New Buy |
| ORBIMED ADVISORS LLC |
| 0.45% | — | #18 | $23.7M | 3.3M | $0 | 0 | +3.3M | New Buy |
| Medicxi Ventures Management (Jersey) Ltd |
| 12.16% | 2.07% | #1 | $21.6M | 3.0M | $20.3M | 3.0M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.7% | 0.52% | #16 | $21.0M | 3.0M | $14.2M | 2.1M | +833,333+39.35% | Add |
| Jupiter Topco LLC |
| 0.01% | — | #40 | $17.8M | 2.5M | $0 | 0 | +2.5M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.15% | — | #24 | $17.8M | 2.5M | $0 | 0 | +2.5M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | <0.01% | #34 | $16.7M | 2.4M | $3.7M | 557,654 | +1.8M+322.24% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #43 | $14.7M | 2.1M | $13.9M | 2.1M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $12.5M | 1.8M | $8.8M | 1.3M | +443,859+33.86% | Add |
| Redmile Group, LLC |
| 0.79% | — | #13 | $11.8M | 1.7M | $0 | 0 | +1.7M | New Buy |
| EcoR1 Capital, LLC |
| 0.58% | — | #17 | $11.8M | 1.7M | $0 | 0 | +1.7M | New Buy |
| Trails Edge Capital Partners, LP |
| 1.63% | — | #6 | $10.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Foresite Capital Management VI LLC |
| 1.47% | — | #8 | $9.5M | 1.3M | $0 | 0 | +1.3M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #78 | $8.7M | 1.2M | $6.5M | 964,670 | +258,314+26.78% | Add |
| Woodline Partners LP |
| 0.03% | — | #33 | $8.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Bellevue Group AG |
| 0.17% | — | #23 | $8.3M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Vivo Capital, LLC |
| 0.76% | — | #14 | $8.3M | 1.2M | $0 | 0 | +1.2M | New Buy |
| ACORN CAPITAL ADVISORS, LLC |
| 1.8% | 1.13% | #4 | $6.6M | 929,077 | $4.0M | 595,744 | +333,333+55.95% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.09% | <0.01% | #25 | $6.4M | 906,356 | $136,489 | 20,402 | +885,954+4,342.49% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $6.2M | 871,342 | $2.6M | 391,334 | +480,008+122.66% | Add |
| LEVIN CAPITAL STRATEGIES, L.P. |
| 0.4% | 0.48% | #19 | $6.0M | 838,067 | $6.3M | 941,400 | -103,333-10.98% | Reduce |
| B Group, Inc. |
| 2.55% | 2.96% | #3 | $5.4M | 764,243 | $4.0M | 597,576 | +166,667+27.89% | Add |
| STEMPOINT CAPITAL LP |
| 0.72% | — | #15 | $5.1M | 714,280 | $0 | 0 | +714,280 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #51 | $4.5M | 637,204 | $2.7M | 397,160 | +240,044+60.44% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #55 | $4.4M | 618,891 | $3.7M | 558,158 | +60,733+10.88% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $4.4M | 617,467 | $7.3M | 1.1M | -480,160-43.75% | Reduce |
| AWM Investment Company, Inc. |
| 0.36% | — | #20 | $4.2M | 591,285 | $0 | 0 | +591,285 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #65 | $3.9M | 549,462 | $2.9M | 430,522 | +118,940+27.63% | Add |
| Regency Capital Management Inc.\DE |
| 1.53% | 1.59% | #7 | $3.8M | 540,395 | $3.6M | 532,495 | +7,900+1.48% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #72 | $3.3M | 464,668 | $1.2M | 178,726 | +285,942+159.99% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #84 | $2.0M | 278,471 | $2.8M | 415,191 | -136,720-32.93% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #106 | $1.8M | 255,331 | $19,361 | 2,894 | +252,437+8,722.77% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #109 | $1.2M | 174,692 | $1.1M | 178,505 | -3,813-2.14% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #47 | $1.2M | 174,200 | $683,049 | 102,100 | +72,100+70.62% | Add |
| Integral Health Asset Management, LLC |
| 0.05% | — | #29 | $1.2M | 170,000 | $0 | 0 | +170,000 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $1.2M | 163,156 | $649,860 | 97,139 | +66,017+67.96% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #35 | $1.1M | 149,931 | $598,895 | 89,521 | +60,410+67.48% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #88 | $938,066 | 132,122 | $853,263 | 127,543 | +4,579+3.59% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #50 | $927,658 | 130,656 | $609,292 | 91,075 | +39,581+43.46% | Add |
| ADAR1 Capital Management, LLC |
| 0.04% | — | #31 | $924,079 | 130,152 | $0 | 0 | +130,152 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #95 | $842,009 | 118,593 | $665,206 | 99,433 | +19,160+19.27% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.2% | 0.19% | #22 | $794,242 | 111,865 | $748,377 | 111,865 | 00.00% | Unchanged |
