| Siren, L.L.C. |
| 0.29% | 0.46% | #4 | $14.4M | 8.5M | $16.6M | 8.5M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $13.2M | 7.8M | $4.0M | 2.1M | +5.7M+279.29% | Add |
| SOFTBANK GROUP CORP. |
| 0.06% | 0.1% | #15 | $10.4M | 6.1M | $11.9M | 6.1M | 00.00% | Unchanged |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | <0.01% | #21 | $8.8M | 5.2M | $2.6M | 1.3M | +3.9M+291.32% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $7.9M | 4.7M | $7.6M | 3.9M | +777,692+19.98% | Add |
| MIC Capital Management UK LLP |
| 1.92% | 2.47% | #1 | $7.6M | 4.5M | $8.7M | 4.5M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #53 | $5.9M | 3.5M | $6.8M | 3.5M | +211+0.01% | Add |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST |
| 0.06% | 0.08% | #13 | $5.6M | 3.3M | $6.5M | 3.3M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $4.4M | 2.6M | $2.1M | 1.1M | +1.5M+139.89% | Add |
| ICONIQ Capital, LLC |
| 0.13% | 0.11% | #10 | $4.4M | 2.6M | $5.0M | 2.6M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #30 | $3.8M | 2.2M | $4.0M | 2.0M | +208,137+10.22% | Add |
| ORBIMED ADVISORS LLC |
| 0.07% | — | #12 | $3.6M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Lunate Capital Ltd |
| 1.84% | 3.44% | #2 | $3.6M | 2.1M | $4.1M | 2.1M | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 0.26% | — | #5 | $3.4M | 2.0M | $0 | 0 | +2.0M | New Buy |
| JOHNSON & JOHNSON |
| 0.39% | 0.55% | #3 | $3.1M | 1.8M | $3.6M | 1.8M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #71 | $2.7M | 1.6M | $777,502 | 398,719 | +1.2M+296.80% | Add |
| Caption Management, LLC |
| 0.01% | 0.01% | #22 | $2.3M | 1.4M | $2.0M | 1.0M | +335,316+32.11% | Add |
| Ikarian Capital, LLC |
| 0.23% | 0.2% | #7 | $2.2M | 1.3M | $2.5M | 1.3M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #29 | $2.1M | 1.3M | $2.7M | 1.4M | -126,694-9.12% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.08% | — | #11 | $1.8M | 1.1M | $0 | 0 | +1.1M | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $1.8M | 1.1M | $820,728 | 420,886 | +647,847+153.92% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #37 | $1.5M | 904,458 | $2.3M | 1.2M | -290,852-24.33% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $1.5M | 894,791 | $360,430 | 184,836 | +709,955+384.10% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $1.4M | 823,583 | $1.0M | 516,182 | +307,401+59.55% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $1.4M | 800,571 | $383,918 | 196,881 | +603,690+306.63% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #66 | $1.4M | 795,814 | $3.0M | 1.5M | -729,527-47.83% | Reduce |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #34 | $1.3M | 784,679 | $0 | 0 | +784,679 | New Buy |
| Stonepine Capital Management, LLC |
| 0.19% | 0.47% | #8 | $1.3M | 500,000 | $1.2M | 600,000 | -100,000-16.67% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $1.2M | 706,667 | $1.0M | 535,033 | +171,634+32.08% | Add |
| AlphaCore Capital LLC |
| 0.02% | 0.03% | #18 | $1.1M | 638,784 | $1.2M | 638,784 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #61 | $982,109 | 577,615 | $691,795 | 354,850 | +222,765+62.78% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $911,516 | 536,186 | $738,000 | 381,494 | +154,692+40.55% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #50 | $865,657 | 509,210 | $5.4M | 2.8M | -2.2M-81.52% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #31 | $689,051 | 405,324 | $534,046 | 273,870 | +131,454+48.00% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #42 | $617,347 | 363,145 | $304,617 | 156,214 | +206,931+132.47% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #23 | $569,954 | 335,267 | $653,771 | 335,267 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #90 | $543,017 | 319,421 | $500,075 | 274,767 | +44,654+16.25% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #83 | $516,566 | 303,862 | $1.1M | 568,280 | -264,418-46.53% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #85 | $458,711 | 269,830 | $1.5M | 747,665 | -477,835-63.91% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #77 | $420,827 | 247,545 | $76,405 | 39,182 | +208,363+531.78% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #87 | $413,432 | 243,195 | $401,562 | 205,929 | +37,266+18.10% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.03% | 0.03% | #17 | $409,887 | 241,110 | $425,000 | 217,950 | +23,160+10.63% | Add |
| Cerity Partners LLC |
| <0.01% | <0.01% | #45 | $407,411 | 239,653 | $507,763 | 260,391 | -20,738-7.96% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #25 | $404,170 | 237,747 | $312,622 | 160,319 | +77,428+48.30% | Add |
| Velan Capital Investment Management LP |
| 0.24% | 0.1% | #6 | $391,000 | 230,000 | $156,000 | 80,000 | +150,000+187.50% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #24 | $382,500 | 225,000 | $438,750 | 225,000 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.02% | <0.01% | #19 | $357,000 | 210,000 | $64,545 | 33,100 | +176,900+534.44% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #56 | $339,677 | 199,810 | $251,854 | 129,156 | +70,654+54.70% | Add |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #59 | $337,280 | 198,400 | $273,390 | 140,200 | +58,200+41.51% | Add |
| Addis & Hill, Inc |
| 0.15% | 0.19% | #9 | $277,757 | 163,386 | $318,603 | 163,386 | 00.00% | Unchanged |
