| Jupiter Topco LLC |
| 0.05% | — | #18 | $121.7M | 1.3M | $0 | 0 | +1.3M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.54% | 0.39% | #5 | $61.8M | 667,207 | $36.6M | 667,207 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $32.3M | 348,819 | $17.3M | 316,567 | +32,252+10.19% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.31% | 0.21% | #10 | $30.0M | 323,745 | $17.7M | 323,745 | 00.00% | Unchanged |
| Saturn V Capital Management LP |
| 4.14% | 3.43% | #1 | $28.9M | 311,976 | $18.9M | 345,626 | -33,650-9.74% | Reduce |
| Siren, L.L.C. |
| 0.51% | 0.41% | #6 | $25.0M | 270,118 | $14.8M | 270,118 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.93% | 0.85% | #2 | $20.1M | 217,595 | $14.5M | 264,278 | -46,683-17.66% | Reduce |
| Polar Capital Holdings Plc |
| 0.05% | 0.04% | #19 | $19.9M | 214,469 | $12.4M | 226,526 | -12,057-5.32% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $19.4M | 209,711 | $12.0M | 218,463 | -8,752-4.01% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.03% | #23 | $19.4M | 209,195 | $16.9M | 309,195 | -100,000-32.34% | Reduce |
| TCG Crossover Management, LLC |
| 0.45% | 0.21% | #8 | $18.8M | 203,327 | $7.2M | 132,103 | +71,224+53.92% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #38 | $14.7M | 158,437 | $9.6M | 174,342 | -15,905-9.12% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.27% | — | #11 | $14.6M | 157,423 | $0 | 0 | +157,423 | New Buy |
| Candriam S.C.A. |
| 0.06% | — | #17 | $13.3M | 143,339 | $0 | 0 | +143,339 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #27 | $12.5M | 134,543 | $7.5M | 136,443 | -1,900-1.39% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $10.4M | 112,578 | $5.5M | 99,918 | +12,660+12.67% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #24 | $9.3M | 100,000 | $5.5M | 100,000 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $8.6M | 92,551 | $4.8M | 88,355 | +4,196+4.75% | Add |
| Vivo Capital, LLC |
| 0.77% | 0.41% | #4 | $8.4M | 90,500 | $5.0M | 90,500 | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.05% | 0.01% | #20 | $7.8M | 84,040 | $1.8M | 33,156 | +50,884+153.47% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #42 | $7.1M | 76,942 | $4.3M | 78,618 | -1,676-2.13% | Reduce |
| Vestal Point Capital, LP |
| 0.16% | 0.1% | #13 | $7.0M | 75,727 | $3.6M | 65,418 | +10,309+15.76% | Add |
| Longaeva Partners L.P. |
| 0.11% | — | #15 | $5.2M | 55,834 | $0 | 0 | +55,834 | New Buy |
| Neuberger Berman Group LLC |
| <0.01% | <0.01% | #37 | $5.1M | 55,194 | $2.3M | 42,434 | +12,760+30.07% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $4.7M | 50,311 | $2.9M | 52,951 | -2,640-4.99% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $4.5M | 48,816 | $2.5M | 45,987 | +2,829+6.15% | Add |
| Ikarian Capital, LLC |
| 0.47% | — | #7 | $4.4M | 47,861 | $0 | 0 | +47,861 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #58 | $3.4M | 37,004 | $3.2M | 58,436 | -21,432-36.68% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $3.2M | 34,641 | $1.7M | 31,862 | +2,779+8.72% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #47 | $2.9M | 31,008 | $1.6M | 28,822 | +2,186+7.58% | Add |
| STEMPOINT CAPITAL LP |
| 0.4% | — | #9 | $2.8M | 30,125 | $0 | 0 | +30,125 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $2.6M | 28,280 | $1.6M | 28,447 | -167-0.59% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #61 | $2.5M | 27,259 | $2.2M | 39,436 | -12,177-30.88% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $1.7M | 17,919 | $1.3M | 15,711 | +2,208+14.05% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #60 | $1.6M | 17,800 | $373,614 | 6,819 | +10,981+161.04% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $1.5M | 16,161 | $1.9M | 34,710 | -18,549-53.44% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #43 | $1.4M | 14,850 | $780,707 | 14,249 | +601+4.22% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | — | #26 | $1.4M | 14,689 | $0 | 0 | +14,689 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #66 | $1.3M | 13,953 | $688,053 | 12,558 | +1,395+11.11% | Add |
| Ishara Investments LP |
| 0.82% | — | #3 | $1.1M | 12,300 | $0 | 0 | +12,300 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #48 | $1.1M | 12,252 | $535,024 | 9,765 | +2,487+25.47% | Add |
| Trexquant Investment LP |
| 0.01% | — | #34 | $1.1M | 12,004 | $0 | 0 | +12,004 | New Buy |
| Creative Planning |
| <0.01% | <0.01% | #55 | $719,239 | 7,768 | $328,028 | 5,987 | +1,781+29.75% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #21 | $697,388 | 7,532 | $0 | 0 | +7,532 | New Buy |
| XTX Topco Ltd |
| 0.01% | — | #31 | $605,168 | 6,536 | $0 | 0 | +6,536 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #69 | $553,688 | 5,980 | $304,139 | 5,551 | +429+7.73% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #72 | $540,077 | 5,833 | $1.4M | 24,935 | -19,102-76.61% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #57 | $521,271 | 5,630 | $270,981 | 4,946 | +684+13.83% | Add |
| GERBER, LLC |
| 0.24% | 0.17% | #12 | $518,597 | 5,601 | $306,879 | 5,601 | 00.00% | Unchanged |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #68 | $506,838 | 5,474 | $0 | 0 | +5,474 | New Buy |
