| Caligan Partners LP |
| 1.46% | 2.03% | #4 | $31.1M | 8.0M | $30.5M | 8.0M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 2.6% | 3.64% | #1 | $28.5M | 7.3M | $43.7M | 11.4M | -4.1M-36.08% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.39% | 0.48% | #7 | $25.8M | 6.6M | $24.6M | 6.4M | +195,758+3.04% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #20 | $25.0M | 6.4M | $13.0M | 3.4M | +3.0M+88.09% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.15% | 0.18% | #12 | $17.2M | 4.4M | $16.9M | 4.4M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #23 | $14.7M | 3.8M | $14.4M | 3.8M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #49 | $12.0M | 3.1M | $1.2M | 301,326 | +2.8M+917.51% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $11.6M | 3.0M | $9.6M | 2.5M | +479,192+19.22% | Add |
| Commodore Capital LP |
| 0.67% | 0.98% | #5 | $11.2M | 2.9M | $16.9M | 4.4M | -1.5M-34.79% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $10.7M | 2.7M | $11.6M | 3.0M | -283,610-9.35% | Reduce |
| Spruce Street Capital LP |
| 1.68% | 2.02% | #3 | $8.6M | 2.2M | $8.4M | 2.2M | 00.00% | Unchanged |
| Sessa Capital IM, L.P. |
| 0.14% | 0.15% | #13 | $8.6M | 2.2M | $8.4M | 2.2M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.27% | 0.11% | #8 | $5.9M | 1.5M | $2.2M | 575,000 | +950,000+165.22% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.07% | #16 | $5.8M | 1.5M | $5.7M | 1.5M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $5.0M | 1.3M | $1.2M | 302,036 | +975,149+322.86% | Add |
| Woodline Partners LP |
| 0.01% | 0.04% | #24 | $4.6M | 1.2M | $10.9M | 2.9M | -1.7M-58.61% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #26 | $4.6M | 1.2M | $5.3M | 1.4M | -202,969-14.75% | Reduce |
| Propel Bio Management, LLC |
| 2.2% | 2.45% | #2 | $4.2M | 1.1M | $3.9M | 1.0M | +63,788+6.30% | Add |
| Soleus Capital Management, L.P. |
| 0.12% | 0.16% | #15 | $3.5M | 900,000 | $4.0M | 1.1M | -150,000-14.29% | Reduce |
| Seven Fleet Capital Management LP |
| 0.47% | 0.12% | #6 | $2.9M | 736,077 | $383,000 | 100,000 | +636,077+636.08% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #40 | $2.4M | 611,019 | $5.7M | 1.5M | -865,087-58.61% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #61 | $2.1M | 530,831 | $284,305 | 74,231 | +456,600+615.11% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #52 | $1.8M | 466,915 | $175,797 | 45,900 | +421,015+917.24% | Add |
| DV EQUITIES, LLC |
| 0.22% | — | #9 | $1.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| AWM Investment Company, Inc. |
| 0.13% | 0.17% | #14 | $1.5M | 375,000 | $1.5M | 400,000 | -25,000-6.25% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $1.5M | 373,980 | $756,881 | 197,619 | +176,361+89.24% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #48 | $1.4M | 365,878 | $178,567 | 46,623 | +319,255+684.76% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #50 | $1.4M | 362,489 | $219,942 | 57,426 | +305,063+531.23% | Add |
| STEMPOINT CAPITAL LP |
| 0.19% | 0.26% | #11 | $1.3M | 342,631 | $1.4M | 375,000 | -32,369-8.63% | Reduce |
| HB Wealth Management, LLC |
| 0.01% | 0.01% | #27 | $1.2M | 307,500 | $1.2M | 307,500 | 00.00% | Unchanged |
| Polymer Capital Management (HK) LTD |
| 0.06% | — | #17 | $1.2M | 306,581 | $0 | 0 | +306,581 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #55 | $1.1M | 294,734 | $315,592 | 82,400 | +212,334+257.69% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #65 | $1.1M | 292,728 | $0 | 0 | +292,728 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $837,065 | 214,632 | $693,939 | 181,185 | +33,447+18.46% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $746,089 | 191,305 | $436,390 | 113,940 | +77,365+67.90% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $560,808 | 143,797 | $266,568 | 69,600 | +74,197+106.60% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #57 | $420,604 | 107,847 | $0 | 0 | +107,847 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #63 | $412,160 | 105,682 | $0 | 0 | +105,682 | New Buy |
| Simplify Asset Management Inc. |
| 0.01% | 0.01% | #28 | $408,911 | 104,849 | $717,091 | 187,230 | -82,381-44.00% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #51 | $330,271 | 84,685 | $143,453 | 37,455 | +47,230+126.10% | Add |
| ALPS ADVISORS INC |
| <0.01% | — | #31 | $302,640 | 77,600 | $0 | 0 | +77,600 | New Buy |
| Stonepine Capital Management, LLC |
| 0.04% | 0.08% | #19 | $285,757 | 73,271 | $191,500 | 50,000 | +23,271+46.54% | Add |
| Nuveen, LLC |
| <0.01% | — | #64 | $227,752 | 58,398 | $0 | 0 | +58,398 | New Buy |
| Pathstone Holdings, LLC |
| <0.01% | <0.01% | #36 | $197,537 | 50,650 | $193,991 | 50,650 | 00.00% | Unchanged |
| Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #34 | $194,263 | 49,811 | $236,468 | 61,741 | -11,930-19.32% | Reduce |
| FIFTH LANE CAPITAL, LP |
| 0.21% | 0.22% | #10 | $178,095 | 46,500 | $178,095 | 46,500 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | — | #53 | $176,133 | 45,164 | $0 | 0 | +45,164 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #72 | $171,924 | 44,083 | $0 | 0 | +44,083 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #66 | $165,247 | 42,371 | $0 | 0 | +42,371 | New Buy |
| IFP Advisors, Inc |
| <0.01% | — | #30 | $150,926 | 38,699 | $0 | 0 | +38,699 | New Buy |
