| RA CAPITAL MANAGEMENT, L.P. |
| 0.38% | 0.43% | #10 | $43.5M | 17.8M | $40.1M | 17.8M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 1.04% | 1.12% | #7 | $43.4M | 17.8M | $39.0M | 17.8M | 00.00% | Unchanged |
| Versant Venture Management, LLC |
| 18.33% | 19.44% | #1 | $29.8M | 12.2M | $27.5M | 12.2M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 0.34% | 0.35% | #11 | $23.2M | 9.5M | $21.4M | 9.5M | -25,100-0.26% | Reduce |
| RTW INVESTMENTS, LP |
| 0.18% | 0.2% | #13 | $21.3M | 8.7M | $19.7M | 8.7M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 0.65% | 0.73% | #9 | $21.3M | 8.7M | $19.7M | 8.7M | 00.00% | Unchanged |
| Commodore Capital LP |
| 1.27% | 1.14% | #5 | $21.3M | 8.7M | $19.7M | 8.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $19.8M | 8.1M | $3.4M | 1.5M | +6.6M+430.81% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $14.0M | 5.7M | $12.9M | 5.7M | +17,476+0.31% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #22 | $13.5M | 5.5M | $11.3M | 5.0M | +505,211+10.07% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.02% | #24 | $12.2M | 5.0M | $13.5M | 6.0M | -984,152-16.50% | Reduce |
| Seven Fleet Capital Management LP |
| 1.76% | 2.11% | #3 | $10.7M | 4.3M | $6.7M | 2.9M | +1.4M+47.49% | Add |
| Woodline Partners LP |
| 0.03% | 0.03% | #20 | $10.4M | 4.3M | $6.9M | 3.0M | +1.2M+39.89% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $10.3M | 4.2M | $10.5M | 4.7M | -472,082-10.12% | Reduce |
| Trails Edge Capital Partners, LP |
| 1.61% | 1.27% | #4 | $10.1M | 4.1M | $5.5M | 2.4M | +1.7M+68.77% | Add |
| Spruce Street Capital LP |
| 1.95% | 2.21% | #2 | $9.9M | 4.1M | $9.2M | 4.1M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #25 | $9.3M | 3.8M | $8.6M | 3.8M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $7.3M | 3.0M | $2.9M | 1.3M | +1.7M+128.90% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #29 | $6.6M | 2.7M | $5.4M | 2.4M | +327,583+13.81% | Add |
| DAFNA Capital Management LLC |
| 1.12% | 1.25% | #6 | $5.9M | 2.4M | $5.5M | 2.4M | -33,895-1.39% | Reduce |
| STEMPOINT CAPITAL LP |
| 0.75% | — | #8 | $5.3M | 2.1M | $0 | 0 | +2.1M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #57 | $4.5M | 1.8M | $873,994 | 386,723 | +1.5M+376.61% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #43 | $3.9M | 1.6M | $521,653 | 230,820 | +1.4M+590.56% | Add |
| DV Trading LLC |
| 0.11% | — | #16 | $3.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Rock Springs Capital Management LP |
| 0.16% | 0.17% | #14 | $3.2M | 1.3M | $2.9M | 1.3M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $3.1M | 1.3M | $2.0M | 906,827 | +350,873+38.69% | Add |
| Casdin Capital, LLC |
| 0.15% | 0.21% | #15 | $3.0M | 1.2M | $2.8M | 1.2M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $2.5M | 1.0M | $0 | 0 | +1.0M | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $1.8M | 737,522 | $1.6M | 692,963 | +44,559+6.43% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #34 | $1.3M | 537,994 | $1.5M | 673,584 | -135,590-20.13% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #66 | $934,477 | 381,419 | $140,366 | 62,109 | +319,310+514.11% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #58 | $928,224 | 378,867 | $179,478 | 79,415 | +299,452+377.07% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #63 | $861,837 | 351,770 | $29,606 | 13,100 | +338,670+2,585.27% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #60 | $732,584 | 299,014 | $29,147 | 12,897 | +286,117+2,218.48% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #59 | $664,720 | 271,492 | $122,209 | 55,183 | +216,309+391.98% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #67 | $569,402 | 232,409 | $32,126 | 14,215 | +218,194+1,534.96% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #52 | $426,452 | 174,062 | $132,757 | 58,742 | +115,320+196.32% | Add |
| Nuveen, LLC |
| <0.01% | — | #64 | $400,800 | 163,592 | $0 | 0 | +163,592 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $389,288 | 158,893 | $327,924 | 145,099 | +13,794+9.51% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $368,561 | 150,433 | $475,689 | 210,482 | -60,049-28.53% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #72 | $364,842 | 148,915 | $90 | 40 | +148,875+372,187.50% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #51 | $314,584 | 128,404 | $0 | 0 | +128,404 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.01% | #21 | $295,465 | 120,598 | $174,000 | 76,836 | +43,762+56.96% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #65 | $294,573 | 120,234 | $0 | 0 | +120,234 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $283,690 | 115,792 | $512,313 | 226,687 | -110,895-48.92% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #83 | $247,852 | 101,164 | $0 | 0 | +101,164 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #87 | $240,835 | 98,300 | $64,184 | 28,400 | +69,900+246.13% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #71 | $223,741 | 91,323 | $206,390 | 91,323 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #50 | $220,865 | 90,149 | $270,079 | 119,504 | -29,355-24.56% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #79 | $200,655 | 81,900 | $0 | 0 | +81,900 | New Buy |
