| GILEAD SCIENCES, INC. |
| 8.3% | 5.9% | #1 | $136.8M | 5.0M | $125.0M | 4.5M | +471,698+10.47% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.2% | 0.19% | #15 | $44.1M | 1.6M | $34.1M | 1.2M | +377,000+30.71% | Add |
| Paradigm Biocapital Advisors LP |
| 0.8% | 0.38% | #9 | $42.7M | 1.6M | $18.5M | 665,251 | +888,497+133.56% | Add |
| Commodore Capital LP |
| 2.32% | 1.61% | #3 | $38.9M | 1.4M | $27.8M | 1.0M | +415,000+41.50% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.24% | 0.3% | #13 | $28.0M | 1.0M | $28.3M | 1.0M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.01% | — | #29 | $23.4M | 849,309 | $0 | 0 | +849,309 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $21.1M | 766,819 | $5.6M | 202,743 | +564,076+278.22% | Add |
| Parkman Healthcare Partners LLC |
| 2.03% | 1.18% | #5 | $19.8M | 721,181 | $11.4M | 411,227 | +309,954+75.37% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $15.4M | 558,942 | $13.6M | 490,447 | +68,495+13.97% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #27 | $12.7M | 460,593 | $9.5M | 344,105 | +116,488+33.85% | Add |
| Seven Fleet Capital Management LP |
| 1.96% | 0.49% | #6 | $11.9M | 433,147 | $1.6M | 56,147 | +377,000+671.45% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $8.2M | 298,807 | $6.5M | 233,650 | +65,157+27.89% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #49 | $7.7M | 280,424 | $3.7M | 132,971 | +147,453+110.89% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.02% | 0.02% | #24 | $6.7M | 242,153 | $3.3M | 120,500 | +121,653+100.96% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #40 | $6.3M | 230,000 | $0 | 0 | +230,000 | New Buy |
| DV EQUITIES, LLC |
| 0.89% | — | #8 | $6.2M | 226,415 | $0 | 0 | +226,415 | New Buy |
| Aberdeen Group plc |
| 0.01% | — | #30 | $5.7M | 207,047 | $0 | 0 | +207,047 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.24% | — | #14 | $5.2M | 190,000 | $0 | 0 | +190,000 | New Buy |
| B Group, Inc. |
| 2.27% | 3.61% | #4 | $4.8M | 175,706 | $4.9M | 175,706 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #67 | $4.7M | 171,931 | $1.6M | 56,689 | +115,242+203.29% | Add |
| STEMPOINT CAPITAL LP |
| 0.67% | 0.95% | #10 | $4.7M | 170,378 | $5.1M | 185,435 | -15,057-8.12% | Reduce |
| Squadron Capital Management LLC |
| 1.36% | — | #7 | $4.4M | 160,000 | $0 | 0 | +160,000 | New Buy |
| Woodline Partners LP |
| 0.01% | — | #28 | $4.1M | 150,780 | $0 | 0 | +150,780 | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.02% | — | #23 | $4.1M | 150,000 | $0 | 0 | +150,000 | New Buy |
| Ally Bridge Group (NY) LLC |
| 3.4% | — | #2 | $3.8M | 140,000 | $0 | 0 | +140,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #55 | $3.8M | 137,833 | $1.0M | 36,205 | +101,628+280.70% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #50 | $3.4M | 123,029 | $1.1M | 41,014 | +82,015+199.97% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $3.1M | 114,407 | $705,877 | 25,437 | +88,970+349.77% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #46 | $3.1M | 113,200 | $0 | 0 | +113,200 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $2.5M | 91,153 | $491,813 | 17,723 | +73,430+414.32% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $2.0M | 73,970 | $2.0M | 71,606 | +2,364+3.30% | Add |
| HighVista Strategies LLC |
| 0.46% | 0.57% | #11 | $2.0M | 73,405 | $2.1M | 74,735 | -1,330-1.78% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #38 | $1.4M | 51,488 | $1.9M | 69,256 | -17,768-25.66% | Reduce |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.3% | 0.37% | #12 | $1.3M | 47,580 | $1.3M | 48,390 | -810-1.67% | Reduce |
| Trexquant Investment LP |
| 0.01% | <0.01% | #31 | $1.3M | 45,661 | $631,063 | 22,741 | +22,920+100.79% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #75 | $1.3M | 46,385 | $1.4M | 53,962 | -7,577-14.04% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #76 | $1.2M | 45,219 | $90,291 | 3,527 | +41,692+1,182.08% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.07% | 0.08% | #18 | $1.2M | 42,931 | $1.3M | 45,049 | -2,118-4.70% | Reduce |
| XTX Topco Ltd |
| 0.02% | 0.01% | #26 | $1.2M | 42,918 | $299,284 | 10,785 | +32,133+297.94% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #65 | $1.1M | 41,806 | $10,101 | 364 | +41,442+11,385.16% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #37 | $1.1M | 39,441 | $434,315 | 15,651 | +23,790+152.00% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #42 | $940,201 | 34,214 | $660,561 | 23,804 | +10,410+43.73% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #72 | $800,437 | 29,128 | $0 | 0 | +29,128 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #78 | $741,960 | 27,000 | $914,335 | 32,949 | -5,949-18.06% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #57 | $665,098 | 24,203 | $4,135 | 149 | +24,054+16,143.62% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #71 | $659,933 | 24,015 | $0 | 0 | +24,015 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #41 | $653,062 | 23,765 | $603,868 | 21,761 | +2,004+9.21% | Add |
| Caption Management, LLC |
| <0.01% | 0.01% | #34 | $627,341 | 22,829 | $2.3M | 81,841 | -59,012-72.11% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.03% | 0.03% | #22 | $561,884 | 20,447 | $553,529 | 19,947 | +500+2.51% | Add |
| Palumbo Wealth Management LLC |
| 0.12% | 0.13% | #16 | $545,891 | 19,865 | $545,094 | 19,643 | +222+1.13% | Add |
