| RA CAPITAL MANAGEMENT, L.P. |
| 1.28% | 0.82% | #7 | $147.4M | 11.3M | $77.4M | 11.3M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #37 | $88.5M | 6.8M | $43,819 | 6,397 | +6.8M+106,049.19% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #34 | $44.4M | 3.4M | $588,723 | 85,945 | +3.3M+3,861.68% | Add |
| BRAIDWELL LP |
| 1.35% | 0.35% | #6 | $36.5M | 2.8M | $10.5M | 1.5M | +1.3M+82.87% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | — | #25 | $32.7M | 2.5M | $0 | 0 | +2.5M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $30.7M | 2.4M | $2.8M | 401,649 | +2.0M+486.30% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #45 | $27.7M | 2.1M | $13.1M | 1.9M | +210,313+10.97% | Add |
| Cormorant Asset Management, LP |
| 1.39% | — | #4 | $27.5M | 2.1M | $0 | 0 | +2.1M | New Buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.24% | — | #18 | $25.3M | 1.9M | $0 | 0 | +1.9M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $22.2M | 1.7M | $8.1M | 1.2M | +519,995+44.12% | Add |
| Woodline Partners LP |
| 0.06% | — | #22 | $20.6M | 1.6M | $0 | 0 | +1.6M | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #47 | $16.9M | 1.3M | $2.4M | 345,663 | +952,309+275.50% | Add |
| Redmile Group, LLC |
| 1.07% | — | #8 | $16.0M | 1.2M | $0 | 0 | +1.2M | New Buy |
| GREAT POINT PARTNERS LLC |
| 2.46% | 2.1% | #3 | $13.0M | 1.0M | $9.1M | 1.3M | -334,130-25.04% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.57% | 0.25% | #12 | $12.7M | 972,000 | $4.8M | 700,000 | +272,000+38.86% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $11.8M | 908,198 | $8.7M | 1.3M | -368,062-28.84% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.49% | 0.24% | #13 | $10.7M | 822,649 | $4.1M | 597,662 | +224,987+37.64% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.06% | 0.03% | #23 | $10.3M | 790,000 | $4.1M | 600,946 | +189,054+31.46% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $10.2M | 782,199 | $2.1M | 312,999 | +469,200+149.90% | Add |
| STEMPOINT CAPITAL LP |
| 1.38% | — | #5 | $9.7M | 742,745 | $0 | 0 | +742,745 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #70 | $9.0M | 686,772 | $904,200 | 132,000 | +554,772+420.28% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #48 | $8.6M | 657,971 | $0 | 0 | +657,971 | New Buy |
| Parkman Healthcare Partners LLC |
| 0.75% | — | #10 | $7.3M | 563,484 | $0 | 0 | +563,484 | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.29% | 0.97% | #1 | $6.8M | 521,082 | $1.4M | 199,209 | +321,873+161.58% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.82% | 0.46% | #9 | $6.3M | 483,747 | $2.9M | 419,247 | +64,500+15.38% | Add |
| Invesco Ltd. |
| <0.01% | — | #66 | $4.9M | 373,445 | $0 | 0 | +373,445 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #72 | $4.8M | 365,088 | $173,531 | 86,334 | +278,754+322.88% | Add |
| NAN FUNG TRINITY (HK) Ltd |
| 0.46% | 0.32% | #14 | $4.7M | 360,654 | $2.9M | 420,517 | -59,863-14.24% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #61 | $4.3M | 330,290 | $876,143 | 127,904 | +202,386+158.23% | Add |
| Ikarian Capital, LLC |
| 0.42% | — | #15 | $3.9M | 300,000 | $0 | 0 | +300,000 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #43 | $3.5M | 267,102 | $1.7M | 250,102 | +17,000+6.80% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #42 | $3.5M | 266,649 | $713,886 | 104,217 | +162,432+155.86% | Add |
| Ally Bridge Group (NY) LLC |
| 2.87% | — | #2 | $3.2M | 249,172 | $0 | 0 | +249,172 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $3.1M | 239,657 | $0 | 0 | +239,657 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #57 | $3.1M | 239,451 | $714,543 | 104,437 | +135,014+129.28% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $2.5M | 195,041 | $1.1M | 158,660 | +36,381+22.93% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #41 | $2.5M | 192,700 | $1.5M | 217,300 | -24,600-11.32% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.01% | #27 | $2.4M | 182,645 | $632,234 | 92,297 | +90,348+97.89% | Add |
| FIFTH THIRD BANCORP |
| <0.01% | — | #40 | $2.2M | 164,923 | $0 | 0 | +164,923 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #49 | $2.1M | 164,712 | $1.1M | 156,317 | +8,395+5.37% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #51 | $1.9M | 148,238 | $2.1M | 310,606 | -162,368-52.27% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #80 | $1.7M | 131,761 | $1.3M | 185,975 | -54,214-29.15% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.02% | #28 | $1.7M | 130,300 | $919,955 | 134,300 | -4,000-2.98% | Reduce |
| ArchPoint Investors |
| 0.36% | 0.2% | #16 | $1.7M | 128,900 | $831,590 | 121,400 | +7,500+6.18% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #32 | $1.6M | 126,138 | $0 | 0 | +126,138 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #71 | $1.6M | 123,658 | $0 | 0 | +123,658 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #77 | $1.4M | 104,634 | $151,049 | 22,051 | +82,583+374.51% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #75 | $1.3M | 96,807 | $0 | 0 | +96,807 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #69 | $1.1M | 85,935 | $0 | 0 | +85,935 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $1.1M | 83,230 | $1.0M | 149,970 | -66,740-44.50% | Reduce |
