| FMR LLC |
| <0.01% | <0.01% | #30 | $74.4M | 4.1M | $75.9M | 4.1M | 00.00% | Unchanged |
| BVF INC/IL |
| 1.27% | 1.61% | #9 | $49.5M | 2.7M | $50.5M | 2.7M | 00.00% | Unchanged |
| Fairmount Funds Management LLC |
| 3.27% | 3.65% | #2 | $49.5M | 2.7M | $50.5M | 2.7M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 1.16% | 1.46% | #10 | $38.4M | 2.1M | $39.2M | 2.1M | 00.00% | Unchanged |
| Logos Global Management LP |
| 1.47% | 0.44% | #6 | $34.2M | 1.9M | $8.9M | 482,500 | +1.4M+293.78% | Add |
| FCPM III SERVICES B.V. |
| 4.02% | 4.27% | #1 | $30.2M | 1.7M | $30.8M | 1.7M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.04% | #22 | $29.9M | 1.7M | $27.7M | 1.5M | +152,884+10.12% | Add |
| Vestal Point Capital, LP |
| 0.69% | 0.77% | #12 | $29.3M | 1.6M | $27.6M | 1.5M | +130,000+8.67% | Add |
| Opaleye Management Inc. |
| 2.15% | 3.18% | #4 | $23.7M | 1.3M | $24.1M | 1.3M | +6,736+0.51% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $22.9M | 1.3M | $2.1M | 115,725 | +1.2M+998.95% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.95% | 1.08% | #11 | $20.9M | 1.2M | $21.3M | 1.2M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $13.8M | 767,755 | $14.7M | 801,395 | -33,640-4.20% | Reduce |
| Boxer Capital Management, LLC |
| 0.62% | 1.09% | #13 | $8.2M | 453,686 | $8.3M | 453,686 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $7.3M | 403,859 | $5.9M | 323,553 | +80,306+24.82% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $6.9M | 384,576 | $1.9M | 104,221 | +280,355+269.00% | Add |
| JENNISON ASSOCIATES LLC |
| <0.01% | <0.01% | #28 | $6.8M | 378,507 | $2.8M | 152,974 | +225,533+147.43% | Add |
| RTW INVESTMENTS, LP |
| 0.06% | 0.07% | #19 | $6.7M | 372,856 | $6.8M | 372,856 | 00.00% | Unchanged |
| NEXTBio Capital Management LP |
| 3.09% | 3.18% | #3 | $6.7M | 372,856 | $6.8M | 372,856 | 00.00% | Unchanged |
| Remedium Capital Partners, LLC |
| 1.44% | 2.36% | #7 | $6.5M | 361,250 | $6.6M | 361,250 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #54 | $5.7M | 315,587 | $717,661 | 39,067 | +276,520+707.81% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #36 | $5.4M | 302,568 | $0 | 0 | +302,568 | New Buy |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #26 | $5.4M | 300,000 | $5.5M | 300,000 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #40 | $5.0M | 275,581 | $5.6M | 303,551 | -27,970-9.21% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #31 | $3.9M | 214,300 | $3.7M | 200,780 | +13,520+6.73% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.06% | 0.07% | #20 | $3.7M | 206,942 | $3.8M | 206,942 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #55 | $3.4M | 188,803 | $0 | 0 | +188,803 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $3.4M | 186,874 | $2.1M | 115,828 | +71,046+61.34% | Add |
| STEMPOINT CAPITAL LP |
| 0.47% | — | #14 | $3.3M | 182,382 | $0 | 0 | +182,382 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #42 | $3.2M | 175,182 | $1.5M | 82,706 | +92,476+111.81% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $2.5M | 138,778 | $316,497 | 17,229 | +121,549+705.49% | Add |
| Exome Asset Management LLC |
| 1.42% | 1.46% | #8 | $2.3M | 127,769 | $2.8M | 153,191 | -25,422-16.59% | Reduce |
| SECTORAL ASSET MANAGEMENT INC |
| 1.52% | — | #5 | $2.2M | 121,300 | $0 | 0 | +121,300 | New Buy |
| Woodline Partners LP |
| 0.01% | 0.01% | #27 | $1.7M | 94,488 | $1.4M | 74,000 | +20,488+27.69% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #46 | $1.4M | 75,225 | $907,901 | 49,423 | +25,802+52.21% | Add |
| Burkehill Global Management, LP |
| 0.05% | 0.07% | #21 | $1.3M | 74,000 | $1.4M | 74,000 | 00.00% | Unchanged |
| Blackstone Inc. |
| <0.01% | — | #29 | $1.1M | 62,647 | $0 | 0 | +62,647 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.11% | 0.24% | #15 | $1.1M | 59,104 | $2.4M | 130,500 | -71,396-54.71% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.02% | — | #23 | $914,832 | 50,824 | $0 | 0 | +50,824 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #58 | $904,644 | 50,258 | $0 | 0 | +50,258 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #51 | $857,322 | 47,629 | $0 | 0 | +47,629 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #57 | $824,004 | 45,778 | $0 | 0 | +45,778 | New Buy |
| Stonepine Capital Management, LLC |
| 0.11% | 0.63% | #16 | $720,000 | 40,000 | $1.6M | 85,000 | -45,000-52.94% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #66 | $464,778 | 25,821 | $537,818 | 29,277 | -3,456-11.80% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | — | #44 | $458,766 | 25,487 | $0 | 0 | +25,487 | New Buy |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.01% | #25 | $450,000 | 25,000 | $459,250 | 25,000 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | — | #41 | $434,988 | 24,166 | $0 | 0 | +24,166 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #52 | $410,490 | 22,805 | $0 | 0 | +22,805 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #62 | $354,600 | 19,700 | $0 | 0 | +19,700 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #32 | $346,086 | 19,227 | $384,245 | 20,917 | -1,690-8.08% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.05% | #24 | $328,950 | 18,275 | $923,515 | 50,273 | -31,998-63.65% | Reduce |
