| RA CAPITAL MANAGEMENT, L.P. |
| 0.31% | 0.38% | #4 | $36.1M | 20.1M | $35.5M | 20.1M | 00.00% | Unchanged |
| Commodore Capital LP |
| 0.48% | 0.46% | #1 | $8.1M | 4.5M | $7.9M | 4.5M | 00.00% | Unchanged |
| VIKING GLOBAL INVESTORS LP |
| 0.02% | 0.02% | #18 | $6.3M | 3.5M | $6.2M | 3.5M | 00.00% | Unchanged |
| Laurion Capital Management LP |
| 0.13% | 0.21% | #8 | $5.0M | 2.8M | $4.9M | 2.8M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.21% | 0.17% | #6 | $4.7M | 2.6M | $2.8M | 1.6M | +983,447+61.17% | Add |
| Vivo Capital, LLC |
| 0.38% | 0.34% | #3 | $4.2M | 2.3M | $4.1M | 2.3M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $3.5M | 1.9M | $3.4M | 1.9M | -1,779-0.09% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $3.2M | 1.8M | $3.7M | 2.1M | -292,378-14.06% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $2.7M | 1.5M | $100,536 | 56,800 | +1.5M+2,576.49% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $2.3M | 1.3M | $2.3M | 1.3M | +26,478+2.07% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #28 | $1.6M | 866,992 | $528,466 | 298,568 | +568,424+190.38% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.1% | <0.01% | #11 | $1.5M | 852,852 | $68,000 | 38,286 | +814,566+2,127.58% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $1.2M | 671,481 | $643,788 | 363,722 | +307,759+84.61% | Add |
| AWM Investment Company, Inc. |
| 0.09% | 0.36% | #12 | $1.1M | 600,000 | $3.2M | 1.8M | -1.2M-67.23% | Reduce |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.24% | 0.29% | #5 | $1.1M | 587,688 | $1.1M | 598,663 | -10,975-1.83% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #31 | $952,349 | 529,083 | $259,475 | 146,596 | +382,487+260.91% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $942,806 | 523,473 | $949,228 | 535,999 | -12,526-2.34% | Reduce |
| Creek Drive Management Group LLC |
| 0.39% | 0.18% | #2 | $810,000 | 450,000 | $796,500 | 450,000 | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.09% | 0.11% | #13 | $804,897 | 447,165 | $1.3M | 747,165 | -300,000-40.15% | Reduce |
| DIADEMA PARTNERS LP |
| 0.08% | 0.05% | #14 | $671,911 | 373,284 | $267,137 | 150,925 | +222,359+147.33% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $659,054 | 366,141 | $756,983 | 427,674 | -61,533-14.39% | Reduce |
| Rosalind Advisors, Inc. |
| 0.15% | — | #7 | $630,000 | 350,000 | $0 | 0 | +350,000 | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $503,836 | 279,909 | $495,439 | 279,909 | 00.00% | Unchanged |
| Boxer Capital Management, LLC |
| 0.04% | 0.06% | #17 | $491,206 | 272,892 | $483,019 | 272,892 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #42 | $470,657 | 261,476 | $459,664 | 259,697 | +1,779+0.69% | Add |
| XTX Topco Ltd |
| 0.01% | <0.01% | #23 | $441,625 | 245,347 | $232,137 | 131,151 | +114,196+87.07% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #60 | $412,902 | 229,390 | $406,020 | 229,390 | 00.00% | Unchanged |
| Artia Global Partners LP |
| 0.07% | 0.07% | #15 | $369,583 | 205,324 | $363,423 | 205,324 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #51 | $310,342 | 172,412 | $457,883 | 258,691 | -86,279-33.35% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $302,598 | 168,110 | $245,416 | 138,653 | +29,457+21.25% | Add |
| READYSTATE ASSET MANAGEMENT LP |
| 0.01% | 0.01% | #19 | $203,755 | 115,116 | $203,755 | 115,116 | 00.00% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #33 | $201,728 | 112,071 | $122,348 | 69,123 | +42,948+62.13% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #52 | $199,211 | 110,673 | $166,433 | 94,030 | +16,643+17.70% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #55 | $177,728 | 98,738 | $185,671 | 104,899 | -6,161-5.87% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #38 | $177,446 | 98,581 | $1.3M | 706,472 | -607,891-86.05% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $173,189 | 96,216 | $1.6M | 887,468 | -791,252-89.16% | Reduce |
| RBF Capital, LLC |
| 0.01% | 0.01% | #21 | $171,076 | 95,042 | $168,224 | 95,042 | 00.00% | Unchanged |
| Persistent Asset Partners Ltd |
| 0.05% | 0.03% | #16 | $171,005 | 95,003 | $67,529 | 38,152 | +56,851+149.01% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $168,660 | 93,700 | $77,349 | 43,700 | +50,000+114.42% | Add |
| Rangeley Capital, LLC |
| 0.12% | 0.12% | #9 | $126,000 | 70,000 | $120,530 | 68,096 | +1,904+2.80% | Add |
| Verdad Advisers, LP |
| 0.12% | 0.11% | #10 | $120,384 | 66,880 | $96,253 | 54,380 | +12,500+22.99% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $119,282 | 66,268 | $321,618 | 181,705 | -115,437-63.53% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #56 | $97,319 | 54,113 | $394,101 | 216,824 | -162,711-75.04% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #62 | $87,916 | 48,842 | $2.7M | 575,156 | -526,314-91.51% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #48 | $76,682 | 42,601 | $75,404 | 42,601 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #32 | $73,685 | 40,936 | $281,122 | 158,826 | -117,890-74.23% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #44 | $71,496 | 39,720 | $116,770 | 65,972 | -26,252-39.79% | Reduce |
| Rathbones Group PLC |
| <0.01% | <0.01% | #36 | $57,605 | 32,003 | $56,645 | 32,003 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #54 | $38,700 | 21,500 | $354 | 200 | +21,300+10,650.00% | Add |
| Bronte Capital Management Pty Ltd. |
| <0.01% | — | #25 | $31,997 | 17,776 | $0 | 0 | +17,776 | New Buy |
