| Jupiter Topco LLC |
| 0.04% | — | #21 | $100.8M | 9.8M | $0 | 0 | +9.8M | New Buy |
| Saturn V Capital Management LP |
| 6.89% | 6.09% | #1 | $48.0M | 4.7M | $33.6M | 3.7M | +964,844+26.12% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.54% | 0.38% | #9 | $40.1M | 3.9M | $23.2M | 2.5M | +1.3M+52.65% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #61 | $30.9M | 3.0M | $1.7M | 191,910 | +2.8M+1,461.64% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $30.8M | 3.0M | $4.3M | 468,377 | +2.5M+538.37% | Add |
| Deep Track Capital, LP |
| 0.42% | — | #11 | $28.6M | 2.8M | $0 | 0 | +2.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $25.8M | 2.5M | $16.3M | 1.8M | +719,128+40.22% | Add |
| Opaleye Management Inc. |
| 2.19% | — | #4 | $24.2M | 2.3M | $0 | 0 | +2.3M | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #34 | $21.3M | 2.1M | $15.9M | 1.8M | +316,226+18.07% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #43 | $20.0M | 1.9M | $699,940 | 76,832 | +1.9M+2,427.35% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #25 | $18.5M | 1.8M | $15.0M | 1.6M | +153,356+9.34% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #50 | $17.9M | 1.7M | $3.8M | 415,001 | +1.3M+319.26% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #42 | $15.2M | 1.5M | $0 | 0 | +1.5M | New Buy |
| GREAT POINT PARTNERS LLC |
| 2.49% | 0.73% | #3 | $13.2M | 1.3M | $3.2M | 350,000 | +927,642+265.04% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #64 | $12.4M | 1.2M | $4.2M | 463,384 | +737,713+159.20% | Add |
| Velan Capital Investment Management LP |
| 6.81% | 4.22% | #2 | $11.2M | 1.1M | $6.7M | 740,000 | +345,000+46.62% | Add |
| Bleichroeder LP |
| 1.85% | 1.57% | #5 | $10.3M | 1.0M | $9.1M | 1.0M | 00.00% | Unchanged |
| Logos Global Management LP |
| 0.44% | 0.56% | #10 | $10.3M | 1.0M | $11.2M | 1.2M | -225,000-18.37% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #48 | $10.0M | 969,120 | $8.8M | 969,066 | +54+0.01% | Add |
| Burkehill Global Management, LP |
| 0.2% | 0.13% | #14 | $5.6M | 544,118 | $2.7M | 294,118 | +250,000+85.00% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #65 | $5.5M | 537,757 | $429,746 | 47,173 | +490,584+1,039.97% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #56 | $5.3M | 518,881 | $0 | 0 | +518,881 | New Buy |
| Blue Owl Capital Holdings LP |
| 0.66% | 1.34% | #8 | $4.5M | 437,552 | $5.0M | 547,552 | -110,000-20.09% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #68 | $4.3M | 418,051 | $1.3M | 138,232 | +279,819+202.43% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #38 | $4.3M | 417,227 | $0 | 0 | +417,227 | New Buy |
| LGT Fund Management Co Ltd. |
| 0.18% | 0.16% | #15 | $4.3M | 416,594 | $3.8M | 416,594 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #78 | $4.3M | 413,145 | $374,703 | 41,131 | +372,014+904.46% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #60 | $4.2M | 406,032 | $2.3M | 252,914 | +153,118+60.54% | Add |
| Institute for Wealth Management, LLC. |
| 0.31% | 0.33% | #13 | $3.5M | 337,552 | $3.1M | 337,552 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #86 | $2.9M | 283,711 | $0 | 0 | +283,711 | New Buy |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.36% | — | #12 | $2.8M | 270,000 | $0 | 0 | +270,000 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.11% | — | #17 | $2.6M | 255,000 | $0 | 0 | +255,000 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #71 | $2.4M | 235,720 | $761,696 | 83,611 | +152,109+181.92% | Add |
| KVP Capital Advisors, LP |
| 1.74% | 1.57% | #6 | $2.4M | 230,423 | $2.1M | 230,423 | 00.00% | Unchanged |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #49 | $2.2M | 214,090 | $484,652 | 53,200 | +160,890+302.42% | Add |
| J. Goldman & Co LP |
| 0.05% | 0.06% | #20 | $2.0M | 198,732 | $2.1M | 228,089 | -29,357-12.87% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #85 | $1.8M | 174,107 | $869,130 | 95,404 | +78,703+82.49% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #93 | $1.6M | 159,474 | $252,200 | 120,670 | +38,804+32.16% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #54 | $1.5M | 146,854 | $263,862 | 28,964 | +117,890+407.02% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #53 | $1.5M | 141,964 | $1.7M | 187,675 | -45,711-24.36% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #83 | $1.3M | 127,256 | $250,179 | 27,462 | +99,794+363.39% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #91 | $1.3M | 126,331 | $5.4M | 588,794 | -462,463-78.54% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #81 | $1.2M | 113,320 | $156,227 | 17,149 | +96,171+560.80% | Add |
| Nuveen, LLC |
| <0.01% | — | #79 | $1.1M | 102,979 | $0 | 0 | +102,979 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #69 | $959,923 | 93,106 | $0 | 0 | +93,106 | New Buy |
| Informed Momentum Co LLC |
| 0.09% | 0.13% | #19 | $957,026 | 92,825 | $1.1M | 120,856 | -28,031-23.19% | Reduce |
| TOCQUEVILLE ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #31 | $912,951 | 88,550 | $815,801 | 89,550 | -1,000-1.12% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #26 | $824,800 | 80,000 | $728,800 | 80,000 | 00.00% | Unchanged |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC |
| <0.01% | <0.01% | #40 | $728,731 | 70,682 | $643,913 | 70,682 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #80 | $728,443 | 70,654 | $22,447 | 2,464 | +68,190+2,767.45% | Add |
