| FMR LLC |
| <0.01% | <0.01% | #39 | $97.3M | 2.8M | $87.1M | 2.8M | +13,884+0.49% | Add |
| TCG Crossover Management, LLC |
| 1% | 1.07% | #4 | $41.4M | 1.2M | $37.2M | 1.2M | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.06% | 0.06% | #22 | $39.3M | 1.1M | $35.3M | 1.1M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $29.7M | 862,592 | $26.6M | 860,352 | +2,240+0.26% | Add |
| First Light Asset Management, LLC |
| 1.67% | 1.79% | #3 | $27.5M | 800,726 | $20.0M | 647,743 | +152,983+23.62% | Add |
| BAKER BROS. ADVISORS LP |
| 0.1% | 0.11% | #20 | $20.9M | 607,788 | $18.8M | 607,788 | 00.00% | Unchanged |
| 5AM Venture Management, LLC |
| 7.24% | 5.21% | #1 | $20.9M | 606,660 | $18.8M | 606,660 | 00.00% | Unchanged |
| BRAIDWELL LP |
| 0.76% | 0.87% | #6 | $20.5M | 596,900 | $26.2M | 847,151 | -250,251-29.54% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $16.8M | 488,805 | $14.6M | 473,532 | +15,273+3.23% | Add |
| Vestal Point Capital, LP |
| 0.34% | 0.28% | #8 | $14.6M | 425,000 | $10.1M | 328,000 | +97,000+29.57% | Add |
| Bollard Group LLC |
| 0.32% | 0.29% | #9 | $10.4M | 302,953 | $9.4M | 302,953 | 00.00% | Unchanged |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.17% | 0.19% | #15 | $9.7M | 282,202 | $8.9M | 286,682 | -4,480-1.56% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $9.3M | 270,461 | $8.3M | 268,273 | +2,188+0.82% | Add |
| ORBIMED ADVISORS LLC |
| 0.15% | 0.14% | #16 | $7.8M | 226,600 | $7.0M | 226,600 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #70 | $7.6M | 219,908 | $6.6M | 213,505 | +6,403+3.00% | Add |
| Ikarian Capital, LLC |
| 0.75% | 0.4% | #7 | $7.1M | 205,837 | $4.9M | 157,537 | +48,300+30.66% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $6.5M | 187,700 | $9.1M | 293,475 | -105,775-36.04% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #41 | $6.4M | 186,550 | $3.6M | 116,120 | +70,430+60.65% | Add |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #37 | $5.9M | 172,101 | $7.1M | 229,595 | -57,494-25.04% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $5.7M | 165,525 | $1.8M | 58,348 | +107,177+183.69% | Add |
| Squarepoint Ops LLC |
| 0.01% | 0.01% | #34 | $5.0M | 145,028 | $5.1M | 164,419 | -19,391-11.79% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #51 | $4.9M | 142,448 | $4.4M | 143,432 | -984-0.69% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #54 | $4.0M | 117,428 | $3.5M | 112,664 | +4,764+4.23% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $3.9M | 113,904 | $2.4M | 78,353 | +35,551+45.37% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #64 | $3.7M | 107,393 | $1.6M | 52,400 | +54,993+104.95% | Add |
| Soleus Capital Management, L.P. |
| 0.12% | 0.15% | #19 | $3.5M | 101,684 | $3.8M | 121,684 | -20,000-16.44% | Reduce |
| Woodline Partners LP |
| 0.01% | 0.01% | #30 | $3.4M | 100,000 | $3.1M | 100,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $3.2M | 94,414 | $2.0M | 63,607 | +30,807+48.43% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #71 | $2.5M | 73,924 | $1.9M | 62,426 | +11,498+18.42% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #53 | $2.5M | 72,674 | $2.0M | 64,196 | +8,478+13.21% | Add |
| SECTORAL ASSET MANAGEMENT INC |
| 1.7% | 0.52% | #2 | $2.4M | 71,009 | $628,215 | 19,059 | +51,950+272.57% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $2.4M | 68,394 | $2.1M | 67,895 | +499+0.73% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #75 | $2.3M | 65,821 | $2.1M | 69,000 | -3,179-4.61% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #87 | $2.2M | 65,373 | $1.6M | 104,733 | -39,360-37.58% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #38 | $2.2M | 64,940 | $2.1M | 66,994 | -2,054-3.07% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.02% | #24 | $2.1M | 60,771 | $1.4M | 46,137 | +14,634+31.72% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #91 | $1.8M | 55,364 | $1.7M | 58,870 | -3,506-5.96% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #80 | $1.7M | 48,001 | $5.1M | 164,055 | -116,054-70.74% | Reduce |
| Tetragon Partners GP Ltd |
| 0.25% | 0.23% | #10 | $1.6M | 46,516 | $1.2M | 37,588 | +8,928+23.75% | Add |
| PFM Health Sciences, LP |
| 0.13% | 0.13% | #17 | $1.6M | 45,631 | $1.4M | 46,129 | -498-1.08% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #43 | $1.5M | 44,540 | $0 | 0 | +44,540 | New Buy |
| Jump Financial, LLC |
| 0.01% | 0.02% | #28 | $1.5M | 43,400 | $1.3M | 43,098 | +302+0.70% | Add |
| Prosight Management, LP |
| 0.24% | 0.4% | #11 | $1.4M | 39,731 | $2.5M | 79,872 | -40,141-50.26% | Reduce |
| Trexquant Investment LP |
| 0.01% | — | #32 | $1.3M | 36,991 | $0 | 0 | +36,991 | New Buy |
| Aldebaran Capital, LLC |
| 0.95% | 0.88% | #5 | $1.3M | 36,797 | $1.1M | 37,184 | -387-1.04% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.01% | — | #31 | $1.2M | 35,239 | $0 | 0 | +35,239 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #76 | $1.1M | 31,432 | $903,808 | 29,240 | +2,192+7.50% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $1.0M | 30,438 | $899,790 | 29,110 | +1,328+4.56% | Add |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.22% | 0.23% | #12 | $967,416 | 28,143 | $826,935 | 26,753 | +1,390+5.20% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $867,872 | 25,247 | $765,336 | 24,760 | +487+1.97% | Add |
