| FMR LLC |
| <0.01% | <0.01% | #33 | $110.7M | 5.7M | $88.9M | 4.9M | +840,962+17.34% | Add |
| TPG GP A, LLC |
| 1.46% | 1.98% | #5 | $73.2M | 3.8M | $72.7M | 4.0M | -206,268-5.20% | Reduce |
| Red Tree Management, LLC |
| 29.13% | 36.15% | #2 | $42.9M | 2.2M | $40.4M | 2.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $37.7M | 1.9M | $33.2M | 1.8M | +122,938+6.78% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $22.0M | 1.1M | $20.8M | 1.1M | -6,786-0.60% | Reduce |
| KCM Capital Inc |
| 1.38% | 4.13% | #6 | $21.9M | 1.1M | $25.7M | 1.4M | -275,000-19.64% | Reduce |
| FEDERATED HERMES, INC. |
| 0.03% | 0.03% | #25 | $18.3M | 939,600 | $17.2M | 939,464 | +136+0.01% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #37 | $17.9M | 918,349 | $14.8M | 809,514 | +108,835+13.44% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #26 | $17.5M | 900,000 | $13.9M | 756,751 | +143,249+18.93% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #41 | $17.4M | 896,488 | $21.3M | 1.2M | -264,279-22.77% | Reduce |
| TimesSquare Capital Management, LLC |
| 0.22% | 0.22% | #10 | $15.2M | 780,552 | $13.1M | 716,468 | +64,084+8.94% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $14.1M | 727,225 | $10.1M | 552,021 | +175,204+31.74% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #61 | $13.0M | 668,134 | $11.2M | 611,977 | +56,157+9.18% | Add |
| ROYCE & ASSOCIATES LP |
| 0.09% | 0.09% | #16 | $11.8M | 605,010 | $9.5M | 515,720 | +89,290+17.31% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #77 | $10.6M | 547,035 | $9.6M | 525,432 | +21,603+4.11% | Add |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.06% | 0.06% | #20 | $9.1M | 468,806 | $9.0M | 489,742 | -20,936-4.27% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| <0.01% | <0.01% | #42 | $7.6M | 389,675 | $9.3M | 508,490 | -118,815-23.37% | Reduce |
| Redmile Group, LLC |
| 0.51% | 0.47% | #7 | $7.5M | 386,786 | $7.1M | 386,786 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #75 | $6.9M | 345,152 | $5.1M | 287,206 | +57,946+20.18% | Add |
| Yu Fan |
| 6.17% | 10.38% | #3 | $6.7M | 342,398 | $10.1M | 549,448 | -207,050-37.68% | Reduce |
| PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.21% | 0.24% | #12 | $6.4M | 331,413 | $6.4M | 348,219 | -16,806-4.83% | Reduce |
| Creek Drive Management Group LLC |
| 2.84% | 1.35% | #4 | $5.9M | 300,881 | $5.9M | 323,000 | -22,119-6.85% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #81 | $5.6M | 285,661 | $1.8M | 154,545 | +131,116+84.84% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $5.5M | 280,309 | $7.5M | 411,031 | -130,722-31.80% | Reduce |
| ABG-WTT Global Life Science Capital Partners GP Ltd |
| 62.61% | 65.87% | #1 | $5.4M | 275,328 | $8.1M | 441,820 | -166,492-37.68% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $5.0M | 255,464 | $3.9M | 214,201 | +41,263+19.26% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #79 | $4.6M | 237,472 | $5.9M | 319,837 | -82,365-25.75% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $4.1M | 208,935 | $3.5M | 190,711 | +18,224+9.56% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $3.8M | 195,471 | $3.5M | 189,482 | +5,989+3.16% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $3.8M | 194,724 | $5.3M | 288,114 | -93,390-32.41% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #84 | $3.4M | 175,022 | $787,658 | 42,971 | +132,051+307.30% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $3.2M | 166,530 | $3.0M | 163,066 | +3,464+2.12% | Add |
| HRT FINANCIAL LP |
| 0.01% | 0.01% | #31 | $3.2M | 166,318 | $2.5M | 135,423 | +30,895+22.81% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #48 | $2.9M | 149,042 | $1.6M | 84,721 | +64,321+75.92% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #39 | $2.7M | 140,250 | $2.6M | 140,347 | -97-0.07% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #51 | $2.5M | 129,604 | $1.9M | 105,973 | +23,631+22.30% | Add |
| ExodusPoint Capital Management, LP |
| 0.01% | — | #28 | $2.3M | 119,250 | $0 | 0 | +119,250 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #45 | $2.1M | 109,867 | $6.0M | 326,032 | -216,165-66.30% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #40 | $2.1M | 109,627 | $0 | 0 | +109,627 | New Buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.13% | 0.03% | #14 | $2.1M | 106,819 | $514,157 | 28,050 | +78,769+280.82% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #44 | $1.9M | 96,251 | $1.4M | 77,733 | +18,518+23.82% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $1.9M | 95,657 | $967,604 | 52,788 | +42,869+81.21% | Add |
| Voleon Capital Management LP |
| 0.03% | 0.02% | #23 | $1.8M | 94,539 | $1.1M | 61,038 | +33,501+54.89% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #68 | $1.7M | 89,581 | $1.6M | 88,502 | +1,079+1.22% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.06% | 0.08% | #19 | $1.7M | 89,348 | $1.6M | 88,354 | +994+1.13% | Add |
| F/m Investments LLC |
| 0.09% | 0.11% | #17 | $1.7M | 89,348 | $1.6M | 88,354 | +994+1.13% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #82 | $1.7M | 87,698 | $1.5M | 83,126 | +4,572+5.50% | Add |
| Numerai GP LLC |
| 0.14% | 0.13% | #13 | $1.7M | 87,271 | $1.3M | 69,052 | +18,219+26.38% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #65 | $1.6M | 80,497 | $779,868 | 42,546 | +37,951+89.20% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #85 | $1.1M | 58,795 | $1.0M | 54,874 | +3,921+7.15% | Add |
