| Polar Capital Holdings Plc |
| 0.12% | 0.15% | #9 | $52.4M | 3.3M | $43.4M | 3.3M | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 1.59% | 1.56% | #2 | $46.3M | 2.9M | $38.6M | 2.9M | -21,085-0.72% | Reduce |
| First Light Asset Management, LLC |
| 2.76% | 2.9% | #1 | $45.5M | 2.9M | $32.3M | 2.5M | +401,201+16.31% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #27 | $42.2M | 2.7M | $26.3M | 2.5M | +108,183+4.25% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $39.4M | 2.5M | $30.9M | 2.3M | +131,270+5.59% | Add |
| ORBIMED ADVISORS LLC |
| 0.45% | 0.55% | #5 | $23.9M | 1.5M | $27.6M | 2.1M | -591,402-28.21% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.13% | 0.14% | #8 | $23.0M | 1.4M | $19.1M | 1.5M | -4,220-0.29% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $19.5M | 1.2M | $14.8M | 1.1M | +103,361+9.20% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #20 | $14.9M | 938,919 | $12.3M | 932,090 | +6,829+0.73% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.13% | 0.16% | #7 | $11.0M | 692,000 | $9.1M | 692,000 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $10.6M | 666,300 | $8.1M | 618,119 | +48,181+7.79% | Add |
| FMR LLC |
| <0.01% | <0.01% | #46 | $8.8M | 554,771 | $7.3M | 553,529 | +1,242+0.22% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #51 | $8.7M | 550,132 | $6.5M | 497,546 | +52,586+10.57% | Add |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.04% | 0.03% | #15 | $5.5M | 344,124 | $4.7M | 360,065 | -15,941-4.43% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $4.1M | 260,025 | $3.2M | 239,840 | +20,185+8.42% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #22 | $3.5M | 221,237 | $2.4M | 186,189 | +35,048+18.82% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $3.5M | 220,371 | $2.5M | 187,429 | +32,942+17.58% | Add |
| Palumbo Wealth Management LLC |
| 0.7% | 0.68% | #4 | $3.3M | 209,199 | $2.8M | 210,469 | -1,270-0.60% | Reduce |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.43% | 0.45% | #6 | $3.3M | 208,703 | $2.9M | 217,738 | -9,035-4.15% | Reduce |
| ALGERT GLOBAL LLC |
| 0.03% | 0.04% | #16 | $2.9M | 184,774 | $2.4M | 179,556 | +5,218+2.91% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #39 | $2.9M | 182,534 | $2.3M | 178,646 | +3,888+2.18% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #64 | $2.9M | 173,311 | $1.8M | 141,141 | +32,170+22.79% | Add |
| HighMark Wealth Management LLC |
| 0.87% | 0.34% | #3 | $2.6M | 163,000 | $828,450 | 63,000 | +100,000+158.73% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #30 | $2.6M | 162,164 | $2.4M | 179,021 | -16,857-9.42% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #33 | $2.6M | 161,081 | $573,669 | 43,625 | +117,456+269.24% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #55 | $2.4M | 149,566 | $2.3M | 175,362 | -25,796-14.71% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $2.0M | 128,800 | $1.1M | 87,284 | +41,516+47.56% | Add |
| LAZARD ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $2.0M | 127,728 | $1.6M | 124,305 | +3,423+2.75% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.12% | 0.1% | #10 | $1.8M | 115,535 | $1.5M | 117,672 | -2,137-1.82% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #19 | $1.8M | 114,059 | $1.5M | 114,275 | -216-0.19% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #25 | $1.8M | 111,699 | $2.3M | 174,311 | -62,612-35.92% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #26 | $1.7M | 109,874 | $1.8M | 135,705 | -25,831-19.03% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #48 | $1.6M | 99,498 | $1.2M | 89,287 | +10,211+11.44% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| <0.01% | — | #29 | $1.5M | 94,800 | $0 | 0 | +94,800 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #38 | $1.4M | 87,677 | $999,019 | 75,971 | +11,706+15.41% | Add |
| Man Group plc |
| <0.01% | <0.01% | #28 | $1.3M | 84,073 | $577,246 | 43,897 | +40,176+91.52% | Add |
| NORGES BANK |
| <0.01% | — | #69 | $1.3M | 79,900 | $0 | 0 | +79,900 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $1.2M | 77,831 | $918,015 | 69,811 | +8,020+11.49% | Add |
| Legato Capital Management LLC |
| 0.09% | 0.16% | #11 | $1.1M | 70,334 | $896,843 | 68,201 | +2,133+3.13% | Add |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #37 | $987,993 | 62,177 | $1.6M | 121,476 | -59,299-48.82% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #66 | $921,255 | 57,977 | $687,219 | 52,260 | +5,717+10.94% | Add |
| Informed Momentum Co LLC |
| 0.06% | 0.06% | #14 | $630,134 | 39,656 | $542,950 | 41,289 | -1,633-3.96% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $570,769 | 35,920 | $368,239 | 28,003 | +7,917+28.27% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #80 | $547,220 | 34,438 | $516,690 | 39,292 | -4,854-12.35% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #47 | $503,131 | 31,664 | $387,209 | 29,446 | +2,218+7.53% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #71 | $492,765 | 31,011 | $458,212 | 34,845 | -3,834-11.00% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $486,536 | 30,619 | $534,166 | 40,621 | -10,002-24.62% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #50 | $479,751 | 30,192 | $974,310 | 74,092 | -43,900-59.25% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #36 | $455,916 | 28,692 | $747,367 | 56,834 | -28,142-49.52% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #75 | $435,657 | 27,417 | $190,451 | 14,483 | +12,934+89.30% | Add |
