| MONTANOVA CAPITAL, LLC |
| 0.85% | 0.95% | #11 | $46.6M | 2.8M | $37.1M | 2.8M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.02% | — | #28 | $44.8M | 2.7M | $0 | 0 | +2.7M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $33.8M | 2.1M | $8.7M | 669,123 | +1.4M+208.52% | Add |
| JOHNSON & JOHNSON |
| 4.06% | 3.96% | #4 | $32.4M | 2.0M | $25.8M | 2.0M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #36 | $30.1M | 1.8M | $24.0M | 1.8M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #27 | $25.0M | 1.5M | $22.0M | 1.7M | -162,842-9.66% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $21.7M | 1.3M | $15.9M | 1.2M | +107,183+8.83% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.31% | 0.32% | #16 | $20.6M | 1.3M | $16.4M | 1.3M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #52 | $17.0M | 1.0M | $10.6M | 814,871 | +225,259+27.64% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #37 | $15.3M | 931,709 | $20.1M | 1.5M | -603,740-39.32% | Reduce |
| GREAT POINT PARTNERS LLC |
| 2.85% | 2.4% | #5 | $15.1M | 921,481 | $10.5M | 800,198 | +121,283+15.16% | Add |
| Longaeva Partners L.P. |
| 0.29% | 0.35% | #17 | $13.3M | 812,757 | $9.6M | 732,088 | +80,669+11.02% | Add |
| Ikarian Capital, LLC |
| 1.41% | 0.86% | #7 | $13.2M | 807,874 | $10.6M | 807,874 | 00.00% | Unchanged |
| SECTORAL ASSET MANAGEMENT INC |
| 8.32% | 7.87% | #1 | $11.9M | 727,587 | $9.5M | 727,587 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $11.4M | 693,188 | $3.7M | 282,038 | +411,150+145.78% | Add |
| Hillhouse Capital Advisors, Ltd. |
| 1.32% | 0.52% | #9 | $11.0M | 669,337 | $8.7M | 669,337 | 00.00% | Unchanged |
| Red Tree Management, LLC |
| 7.1% | 7.45% | #2 | $10.5M | 638,158 | $8.3M | 638,158 | 00.00% | Unchanged |
| Versant Venture Management, LLC |
| 5.47% | 5.01% | #3 | $8.9M | 542,628 | $7.1M | 542,628 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #53 | $8.2M | 497,255 | $4.0M | 307,108 | +190,147+61.92% | Add |
| Boxer Capital Management, LLC |
| 0.61% | 0.85% | #13 | $8.1M | 494,000 | $6.5M | 494,000 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #72 | $7.0M | 425,902 | $1.3M | 101,278 | +324,624+320.53% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $6.5M | 396,354 | $4.6M | 350,200 | +46,154+13.18% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #34 | $5.4M | 328,000 | $0 | 0 | +328,000 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.5% | 0.4% | #14 | $4.9M | 296,135 | $3.9M | 301,729 | -5,594-1.85% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.21% | 0.21% | #19 | $4.6M | 278,961 | $3.6M | 276,661 | +2,300+0.83% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $4.6M | 277,804 | $861,020 | 65,928 | +211,876+321.37% | Add |
| Squadron Capital Management LLC |
| 1.32% | — | #8 | $4.3M | 260,000 | $0 | 0 | +260,000 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | 0.04% | #25 | $3.6M | 222,329 | $2.9M | 222,329 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $3.5M | 214,082 | $1.9M | 144,009 | +70,073+48.66% | Add |
| Ishara Investments LP |
| 2.43% | 1.76% | #6 | $3.4M | 205,000 | $1.9M | 142,000 | +63,000+44.37% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.39% | 0.36% | #15 | $3.0M | 183,475 | $2.3M | 173,475 | +10,000+5.76% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #39 | $3.0M | 182,413 | $3.0M | 232,534 | -50,121-21.55% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #80 | $3.0M | 180,302 | $0 | 0 | +180,302 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $2.9M | 178,673 | $782,102 | 59,946 | +118,727+198.06% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #54 | $2.9M | 177,281 | $2.0M | 153,924 | +23,357+15.17% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #65 | $2.5M | 150,797 | $726,254 | 55,609 | +95,188+171.17% | Add |
| Casdin Capital, LLC |
| 0.12% | 0.15% | #23 | $2.4M | 148,333 | $1.9M | 148,333 | 00.00% | Unchanged |
| Eversept Partners, LP |
| 0.13% | 0.1% | #22 | $2.4M | 148,017 | $1.9M | 146,411 | +1,606+1.10% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #69 | $2.1M | 130,642 | $3.0M | 230,409 | -99,767-43.30% | Reduce |
| DIADEMA PARTNERS LP |
| 0.24% | — | #18 | $2.0M | 119,733 | $0 | 0 | +119,733 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #44 | $1.9M | 118,058 | $3.0M | 226,302 | -108,244-47.83% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #83 | $1.5M | 89,859 | $5.0M | 382,936 | -293,077-76.53% | Reduce |
| Trexquant Investment LP |
| 0.01% | <0.01% | #32 | $1.5M | 88,479 | $623,563 | 47,746 | +40,733+85.31% | Add |
| Verdad Advisers, LP |
| 1.27% | 1.26% | #10 | $1.3M | 81,014 | $1.1M | 86,032 | -5,018-5.83% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #55 | $1.3M | 78,920 | $520,820 | 39,879 | +39,041+97.90% | Add |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #38 | $1.1M | 69,441 | $0 | 0 | +69,441 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #45 | $1.1M | 67,300 | $906,364 | 69,400 | -2,100-3.03% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #76 | $1.1M | 65,604 | $0 | 0 | +65,604 | New Buy |
| ACUTA CAPITAL PARTNERS, LLC |
| 0.72% | — | #12 | $1.0M | 63,095 | $0 | 0 | +63,095 | New Buy |
| Seven Fleet Capital Management LP |
| 0.16% | 0.11% | #21 | $992,267 | 60,541 | $353,325 | 27,054 | +33,487+123.78% | Add |
