| FMR LLC |
| <0.01% | <0.01% | #20 | $65.2M | 5.0M | $40.6M | 3.8M | +1.2M+30.16% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $55.9M | 4.3M | $35.1M | 3.3M | +962,046+28.98% | Add |
| Foresite Capital Management IV, LLC |
| 8.74% | 8.67% | #1 | $25.4M | 1.9M | $20.6M | 1.9M | 00.00% | Unchanged |
| Merck & Co., Inc. |
| 4.13% | 5.05% | #3 | $21.7M | 1.7M | $17.6M | 1.7M | 00.00% | Unchanged |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #13 | $20.8M | 1.6M | $12.9M | 1.2M | +372,787+30.49% | Add |
| Foresite Capital Management V, LLC |
| 4.75% | 5.15% | #2 | $17.2M | 1.3M | $14.0M | 1.3M | 00.00% | Unchanged |
| Capital World Investors |
| <0.01% | <0.01% | #24 | $15.3M | 1.2M | $12.1M | 1.1M | +32,307+2.82% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #27 | $13.1M | 1.0M | $10.3M | 975,834 | +29,201+2.99% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $12.0M | 922,707 | $10.3M | 969,431 | -46,724-4.82% | Reduce |
| EcoR1 Capital, LLC |
| 0.46% | 0.33% | #7 | $9.6M | 732,606 | $7.8M | 732,606 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $7.3M | 556,955 | $2.9M | 273,931 | +283,024+103.32% | Add |
| BAKER BROS. ADVISORS LP |
| 0.04% | 0.03% | #12 | $7.2M | 555,555 | $5.9M | 555,555 | 00.00% | Unchanged |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #22 | $6.8M | 641,888 | $10.8M | 1.0M | -380,300-37.20% | Reduce |
| SOROS CAPITAL MANAGEMENT LLC |
| 1.13% | 2.23% | #6 | $6.3M | 484,672 | $5.1M | 484,672 | 00.00% | Unchanged |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #21 | $4.9M | 379,024 | $4.0M | 379,024 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $4.6M | 354,093 | $424,787 | 40,150 | +313,943+781.93% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #29 | $4.6M | 350,000 | $3.7M | 350,000 | 00.00% | Unchanged |
| StepStone Group LP |
| 1.83% | 2.02% | #5 | $4.2M | 395,340 | $4.2M | 395,340 | 00.00% | Unchanged |
| General Catalyst Group Management, LLC |
| 2.11% | 1.76% | #4 | $4.0M | 305,233 | $3.2M | 305,233 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #40 | $3.4M | 263,932 | $1.1M | 99,408 | +164,524+165.50% | Add |
| Parkman Healthcare Partners LLC |
| 0.34% | — | #8 | $3.3M | 256,053 | $0 | 0 | +256,053 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #44 | $2.4M | 182,105 | $1.4M | 131,079 | +51,026+38.93% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #15 | $2.3M | 179,775 | $0 | 0 | +179,775 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #47 | $2.3M | 175,927 | $481,718 | 45,531 | +130,396+286.39% | Add |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #18 | $2.2M | 170,490 | $2.1M | 200,000 | -29,510-14.76% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $1.9M | 148,895 | $144,026 | 13,613 | +135,282+993.77% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #41 | $1.9M | 148,410 | $1.4M | 131,954 | +16,456+12.47% | Add |
| BNP Paribas Asset Management Holding S.A. |
| <0.01% | — | #25 | $1.8M | 134,498 | $0 | 0 | +134,498 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $1.7M | 133,020 | $1.9M | 175,627 | -42,607-24.26% | Reduce |
| Comprehensive Financial Management LLC |
| 0.05% | 0.04% | #11 | $1.5M | 116,276 | $1.2M | 116,276 | 00.00% | Unchanged |
| Burkehill Global Management, LP |
| 0.05% | 0.06% | #10 | $1.5M | 115,000 | $1.2M | 115,000 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.06% | — | #9 | $1.3M | 98,001 | $0 | 0 | +98,001 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #34 | $744,816 | 57,074 | $603,843 | 57,074 | 00.00% | Unchanged |
| ALPS ADVISORS INC |
| <0.01% | — | #19 | $717,071 | 54,948 | $0 | 0 | +54,948 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #61 | $664,245 | 50,900 | $0 | 0 | +50,900 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #54 | $623,634 | 47,788 | $0 | 0 | +47,788 | New Buy |
| TCG Crossover Management, LLC |
| 0.01% | — | #14 | $494,621 | 37,902 | $0 | 0 | +37,902 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #65 | $490,354 | 37,575 | $911,298 | 86,134 | -48,559-56.38% | Reduce |
| POLEN CAPITAL MANAGEMENT LLC |
| <0.01% | — | #17 | $466,433 | 35,742 | $0 | 0 | +35,742 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #43 | $461,409 | 35,357 | $302,831 | 28,623 | +6,734+23.53% | Add |
| ProShare Advisors LLC |
| <0.01% | — | #38 | $387,389 | 29,685 | $0 | 0 | +29,685 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #56 | $378,293 | 28,988 | $0 | 0 | +28,988 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #16 | $358,288 | 27,455 | $275,672 | 26,056 | +1,399+5.37% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #39 | $349,701 | 26,797 | $0 | 0 | +26,797 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #49 | $319,496 | 24,483 | $0 | 0 | +24,483 | New Buy |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #26 | $284,492 | 21,800 | $0 | 0 | +21,800 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #58 | $280,862 | 21,522 | $0 | 0 | +21,522 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #64 | $252,491 | 19,348 | $0 | 0 | +19,348 | New Buy |
| Jump Financial, LLC |
| <0.01% | — | #23 | $235,800 | 18,069 | $0 | 0 | +18,069 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #59 | $218,966 | 16,779 | $0 | 0 | +16,779 | New Buy |
