| BlackRock, Inc. |
| 0.02% | 0.02% | #271 | $1.02B | 6.7M | $1.34B | 6.4M | +314,249+4.93% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.02% | #275 | $689.0M | 4.5M | $960.9M | 4.6M | -53,941-1.18% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.02% | #279 | $486.8M | 3.2M | $638.4M | 3.0M | +155,101+5.10% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.04% | #210 | $468.3M | 3.1M | $723.9M | 3.4M | -374,055-10.84% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.13% | 0.15% | #76 | $373.8M | 2.5M | $335.5M | 1.6M | +856,411+53.57% | Add |
| BAILLIE GIFFORD & CO |
| 0.28% | 0.41% | #45 | $310.9M | 2.0M | $425.9M | 2.0M | +12,821+0.63% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.03% | #248 | $304.0M | 2.0M | $423.6M | 2.0M | -21,837-1.08% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.21% | 0.13% | #55 | $289.8M | 1.9M | $160.0M | 762,349 | +1.1M+149.72% | Add |
| Invesco Ltd. |
| 0.02% | 0.03% | #218 | $258.0M | 1.7M | $230.1M | 1.1M | +598,114+54.55% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.15% | 0.26% | #71 | $230.2M | 1.5M | $381.0M | 1.8M | -303,582-16.72% | Reduce |
| MORGAN STANLEY |
| 0.01% | 0.02% | #313 | $225.2M | 1.5M | $391.8M | 1.3M | +209,941+16.54% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.1% | 0.14% | #91 | $224.0M | 1.5M | $258.1M | 1.2M | +241,141+19.61% | Add |
| Clearbridge Investments, LLC |
| 0.17% | 0.24% | #66 | $200.9M | 1.3M | $277.2M | 1.3M | -1,645-0.12% | Reduce |
| Soleus Capital Management, L.P. |
| 5.5% | 4.78% | #1 | $159.7M | 1.0M | $118.0M | 562,500 | +486,500+86.49% | Add |
| NORGES BANK |
| 0.02% | 0.04% | #256 | $159.6M | 1.0M | $265.7M | 1.0M | +36,320+3.59% | Add |
| JUPITER ASSET MANAGEMENT LTD |
| 0.78% | 0.79% | #18 | $156.3M | 1.0M | $149.0M | 709,902 | +316,789+44.62% | Add |
| FMR LLC |
| 0.01% | 0.04% | #410 | $146.8M | 964,297 | $834.1M | 4.0M | -3.0M-75.74% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.04% | 0.03% | #147 | $131.8M | 865,387 | $62.7M | 298,592 | +566,795+189.82% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #272 | $131.2M | 861,746 | $54.2M | 258,439 | +603,307+233.44% | Add |
| FIL Ltd |
| 0.09% | 0.16% | #98 | $127.9M | 840,026 | $212.4M | 1.0M | -171,979-16.99% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #332 | $124.6M | 818,265 | $181.3M | 863,916 | -45,651-5.28% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.03% | #207 | $117.7M | 773,361 | $166.9M | 795,347 | -21,986-2.76% | Reduce |
| FEDERATED HERMES, INC. |
| 0.15% | 0.24% | #68 | $106.9M | 702,194 | $149.8M | 713,892 | -11,698-1.64% | Reduce |
| Vestal Point Capital, LP |
| 2.38% | 0.3% | #5 | $102.0M | 670,000 | $10.6M | 50,601 | +619,399+1,224.08% | Add |
| Qube Research & Technologies Ltd |
| 0.09% | 0.15% | #96 | $101.1M | 663,968 | $134.6M | 641,676 | +22,292+3.47% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.02% | #318 | $98.9M | 649,908 | $145.6M | 693,817 | -43,909-6.33% | Reduce |
| NORDEA INVESTMENT MANAGEMENT AB |
| 0.08% | 0.11% | #110 | $95.2M | 618,174 | $115.7M | 557,290 | +60,884+10.93% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.88% | 0.37% | #15 | $94.8M | 622,506 | $36.2M | 172,513 | +449,993+260.85% | Add |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #438 | $94.4M | 595,123 | $59.7M | 287,153 | +307,970+107.25% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.02% | #310 | $91.0M | 597,871 | $114.1M | 543,753 | +54,118+9.95% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #335 | $83.4M | 547,818 | $93.6M | 445,939 | +101,879+22.85% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.02% | #268 | $83.4M | 547,577 | $77.5M | 369,197 | +178,380+48.32% | Add |
| Man Group plc |
| 0.13% | 0.27% | #79 | $78.7M | 517,217 | $150.3M | 716,426 | -199,209-27.81% | Reduce |
| Amundi |
| 0.02% | 0.03% | #226 | $77.3M | 507,847 | $93.8M | 446,918 | +60,929+13.63% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.01% | #263 | $77.1M | 506,374 | $63.8M | 304,079 | +202,295+66.53% | Add |
| Alecta Tjanstepension Omsesidigt |
| 0.3% | 0.4% | #42 | $71.5M | 469,400 | $82.7M | 394,300 | +75,100+19.05% | Add |
| Vinva Investment Management Ltd |
| 0.06% | 0.11% | #120 | $68.5M | 430,460 | $48.5M | 228,837 | +201,623+88.11% | Add |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.02% | #175 | $68.3M | 448,320 | $28.0M | 133,597 | +314,723+235.58% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.08% | 0.08% | #108 | $68.0M | 446,382 | $53.8M | 256,584 | +189,798+73.97% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #475 | $64.9M | 426,409 | $83.1M | 396,040 | +30,369+7.67% | Add |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #347 | $60.6M | 398,130 | $80.5M | 383,432 | +14,698+3.83% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.02% | #296 | $60.6M | 398,017 | $85.2M | 406,075 | -8,058-1.98% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.08% | 0.14% | #104 | $56.0M | 367,746 | $82.5M | 393,273 | -25,527-6.49% | Reduce |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.18% | <0.01% | #63 | $53.7M | 352,717 | $352,894 | 1,682 | +351,035+20,870.10% | Add |
| Allianz Asset Management GmbH |
| 0.05% | 0.05% | #144 | $51.9M | 247,097 | $51.9M | 247,097 | 00.00% | Unchanged |
| Stephens Investment Management Group LLC |
| 0.55% | 0.51% | #26 | $51.4M | 337,747 | $37.3M | 177,707 | +160,040+90.06% | Add |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.02% | #274 | $51.2M | 335,980 | $71.7M | 341,687 | -5,707-1.67% | Reduce |
| Quantinno Capital Management LP |
| 0.06% | 0.08% | #126 | $48.3M | 316,922 | $47.2M | 224,951 | +91,971+40.88% | Add |
| Legal & General Group Plc |
| 0.01% | 0.02% | #349 | $47.4M | 311,452 | $68.4M | 326,039 | -14,587-4.47% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.02% | #340 | $44.1M | 289,821 | $62.7M | 298,791 | -8,970-3.00% | Reduce |
