| BlackRock, Inc. |
| <0.01% | <0.01% | #57 | $50.8M | 6.6M | $4.2M | 799,943 | +5.8M+722.03% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | — | #27 | $28.0M | 3.6M | $0 | 0 | +3.6M | New Buy |
| Woodline Partners LP |
| 0.07% | 0.02% | #20 | $23.2M | 3.0M | $5.2M | 1.0M | +2.0M+199.78% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.35% | — | #2 | $22.6M | 2.9M | $0 | 0 | +2.9M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $19.8M | 2.6M | $5.7M | 1.1M | +1.5M+133.53% | Add |
| BVF INC/IL |
| 0.49% | — | #10 | $19.3M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Caligan Partners LP |
| 0.91% | — | #5 | $19.3M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Affinity Asset Advisors, LLC |
| 0.87% | 0.23% | #6 | $19.3M | 2.5M | $4.5M | 868,020 | +1.6M+187.77% | Add |
| FEDERATED HERMES, INC. |
| 0.02% | <0.01% | #31 | $16.1M | 2.1M | $4,081 | 781 | +2.1M+267,085.02% | Add |
| GREAT POINT PARTNERS LLC |
| 2.97% | — | #1 | $15.7M | 2.0M | $0 | 0 | +2.0M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $15.4M | 2.0M | $672,917 | 128,788 | +1.9M+1,449.13% | Add |
| Saturn V Capital Management LP |
| 1.64% | — | #3 | $11.4M | 1.5M | $0 | 0 | +1.5M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #61 | $11.2M | 1.4M | $1.6M | 309,522 | +1.1M+366.53% | Add |
| Blue Owl Capital Holdings LP |
| 1.42% | 0.47% | #4 | $9.7M | 1.3M | $1.7M | 333,877 | +926,667+277.55% | Add |
| BAKER BROS. ADVISORS LP |
| 0.04% | 0.03% | #26 | $7.4M | 952,996 | $5.0M | 952,996 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $7.2M | 937,025 | $4.5M | 862,303 | +74,722+8.67% | Add |
| Aberdeen Group plc |
| 0.01% | — | #35 | $6.6M | 847,700 | $0 | 0 | +847,700 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $5.9M | 759,086 | $884,379 | 169,259 | +589,827+348.48% | Add |
| Hillhouse Capital Advisors, Ltd. |
| 0.67% | 0.23% | #7 | $5.6M | 724,800 | $3.8M | 724,800 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #54 | $4.5M | 581,217 | $0 | 0 | +581,217 | New Buy |
| Vestal Point Capital, LP |
| 0.1% | — | #17 | $4.1M | 535,452 | $0 | 0 | +535,452 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #78 | $3.8M | 486,650 | $1.7M | 323,004 | +163,646+50.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #72 | $3.6M | 468,385 | $290,045 | 55,511 | +412,874+743.77% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | — | #24 | $3.6M | 464,095 | $0 | 0 | +464,095 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.16% | — | #14 | $3.4M | 437,500 | $0 | 0 | +437,500 | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.01% | — | #33 | $3.2M | 415,000 | $0 | 0 | +415,000 | New Buy |
| Seven Fleet Capital Management LP |
| 0.51% | — | #8 | $3.1M | 403,545 | $0 | 0 | +403,545 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #92 | $3.1M | 403,482 | $0 | 0 | +403,482 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #60 | $3.1M | 400,838 | $849,679 | 162,618 | +238,220+146.49% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #63 | $3.1M | 397,972 | $1.4M | 271,217 | +126,755+46.74% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #41 | $2.7M | 346,927 | $3.3M | 625,469 | -278,542-44.53% | Reduce |
| Atom Investors LP |
| 0.24% | — | #13 | $2.7M | 346,018 | $0 | 0 | +346,018 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #75 | $2.6M | 339,930 | $1.5M | 293,934 | +45,996+15.65% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #59 | $2.6M | 332,023 | $1.7M | 317,550 | +14,473+4.56% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $2.2M | 289,933 | $1.1M | 210,773 | +79,160+37.56% | Add |
| Palo Alto Investors LP |
| 0.28% | — | #12 | $1.9M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Rock Springs Capital Management LP |
| 0.09% | — | #18 | $1.9M | 250,000 | $0 | 0 | +250,000 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #76 | $1.8M | 227,931 | $143,316 | 27,429 | +200,502+730.99% | Add |
| Pale Fire Capital SE |
| 0.12% | 0.1% | #16 | $1.7M | 221,875 | $1.2M | 221,875 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.03% | #29 | $1.7M | 221,541 | $1.6M | 299,641 | -78,100-26.06% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #84 | $1.6M | 200,648 | $0 | 0 | +200,648 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #88 | $1.4M | 175,872 | $78,375 | 15,000 | +160,872+1,072.48% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.01% | — | #36 | $1.3M | 166,667 | $0 | 0 | +166,667 | New Buy |
| Sofinnova Investments, Inc. |
| 0.07% | — | #21 | $1.3M | 166,667 | $0 | 0 | +166,667 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #106 | $1.1M | 143,684 | $229,158 | 43,858 | +99,826+227.61% | Add |
| Nuveen, LLC |
| <0.01% | — | #82 | $1.1M | 140,637 | $0 | 0 | +140,637 | New Buy |
| Propel Bio Management, LLC |
| 0.51% | — | #9 | $973,037 | 125,878 | $0 | 0 | +125,878 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #69 | $927,878 | 120,036 | $120,520 | 23,066 | +96,970+420.40% | Add |
| FNY Investment Advisers, LLC |
| 0.31% | 0.35% | #11 | $844,502 | 109,250 | $782,000 | 149,761 | -40,511-27.05% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $790,214 | 102,227 | $1.7M | 246,077 | -143,850-58.46% | Reduce |
