| FMR LLC |
| <0.01% | — | #29 | $96.9M | 5.2M | $0 | 0 | +5.2M | New Buy |
| SR ONE CAPITAL MANAGEMENT, LP |
| 6.83% | — | #3 | $71.0M | 3.8M | $0 | 0 | +3.8M | New Buy |
| TPG GP A, LLC |
| 1.38% | — | #9 | $69.0M | 3.7M | $0 | 0 | +3.7M | New Buy |
| Lightspeed Management Company, L.L.C. |
| 2.81% | — | #5 | $67.5M | 3.6M | $0 | 0 | +3.6M | New Buy |
| ORBIMED ADVISORS LLC |
| 1.06% | — | #10 | $56.2M | 3.0M | $0 | 0 | +3.0M | New Buy |
| Sanofi |
| 6.98% | — | #2 | $37.3M | 2.0M | $0 | 0 | +2.0M | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.2% | — | #17 | $19.6M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Sands Capital Alternatives, LLC |
| 2.67% | — | #6 | $16.4M | 875,000 | $0 | 0 | +875,000 | New Buy |
| Hillhouse Capital Advisors, Ltd. |
| 1.87% | — | #7 | $15.6M | 831,656 | $0 | 0 | +831,656 | New Buy |
| General Catalyst Group Management, LLC |
| 8.04% | — | #1 | $15.2M | 810,272 | $0 | 0 | +810,272 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.65% | — | #12 | $14.3M | 766,346 | $0 | 0 | +766,346 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #24 | $13.6M | 725,000 | $0 | 0 | +725,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #42 | $13.5M | 720,440 | $0 | 0 | +720,440 | New Buy |
| Foresite Capital Management V, LLC |
| 3.68% | — | #4 | $13.3M | 713,105 | $0 | 0 | +713,105 | New Buy |
| Vivo Capital, LLC |
| 0.98% | — | #11 | $10.8M | 575,000 | $0 | 0 | +575,000 | New Buy |
| EcoR1 Capital, LLC |
| 0.51% | — | #14 | $10.4M | 555,555 | $0 | 0 | +555,555 | New Buy |
| Logos Global Management LP |
| 0.42% | — | #15 | $9.8M | 521,736 | $0 | 0 | +521,736 | New Buy |
| MARSHALL WACE, LLP |
| 0.01% | — | #27 | $9.2M | 492,697 | $0 | 0 | +492,697 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #37 | $8.8M | 471,987 | $0 | 0 | +471,987 | New Buy |
| Catalio Capital Management, LP |
| 1.61% | — | #8 | $8.6M | 457,839 | $0 | 0 | +457,839 | New Buy |
| Redmile Group, LLC |
| 0.53% | — | #13 | $8.0M | 425,000 | $0 | 0 | +425,000 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #26 | $7.4M | 393,862 | $0 | 0 | +393,862 | New Buy |
| Woodline Partners LP |
| 0.02% | — | #23 | $6.5M | 345,746 | $0 | 0 | +345,746 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #36 | $5.1M | 275,022 | $0 | 0 | +275,022 | New Buy |
| Boxer Capital Management, LLC |
| 0.39% | — | #16 | $5.1M | 275,000 | $0 | 0 | +275,000 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #51 | $4.5M | 240,679 | $0 | 0 | +240,679 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $4.2M | 222,450 | $0 | 0 | +222,450 | New Buy |
| Siren, L.L.C. |
| 0.08% | — | #19 | $3.7M | 200,000 | $0 | 0 | +200,000 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #45 | $3.5M | 189,488 | $0 | 0 | +189,488 | New Buy |
| Cormorant Asset Management, LP |
| 0.17% | — | #18 | $3.3M | 175,000 | $0 | 0 | +175,000 | New Buy |
| Aberdeen Group plc |
| <0.01% | — | #28 | $3.1M | 165,000 | $0 | 0 | +165,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #33 | $2.9M | 156,602 | $0 | 0 | +156,602 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #44 | $2.5M | 132,801 | $0 | 0 | +132,801 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #43 | $1.9M | 101,531 | $0 | 0 | +101,531 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #41 | $1.9M | 100,905 | $0 | 0 | +100,905 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | — | #31 | $1.4M | 72,918 | $0 | 0 | +72,918 | New Buy |
| UBS Group AG |
| <0.01% | — | #47 | $1.3M | 68,758 | $0 | 0 | +68,758 | New Buy |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #34 | $1.2M | 64,621 | $0 | 0 | +64,621 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.04% | — | #21 | $935,500 | 50,000 | $0 | 0 | +50,000 | New Buy |
| Eversept Partners, LP |
| 0.05% | — | #20 | $929,101 | 49,658 | $0 | 0 | +49,658 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #35 | $826,439 | 44,171 | $0 | 0 | +44,171 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #49 | $647,141 | 34,588 | $0 | 0 | +34,588 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #40 | $601,059 | 32,125 | $0 | 0 | +32,125 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #39 | $545,097 | 29,134 | $0 | 0 | +29,134 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #52 | $524,896 | 27,787 | $0 | 0 | +27,787 | New Buy |
| Ghisallo Capital Management LLC |
| <0.01% | — | #32 | $467,750 | 25,000 | $0 | 0 | +25,000 | New Buy |
| Burkehill Global Management, LP |
| 0.01% | — | #25 | $374,200 | 20,000 | $0 | 0 | +20,000 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #46 | $371,356 | 19,848 | $0 | 0 | +19,848 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #30 | $309,688 | 16,552 | $0 | 0 | +16,552 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #53 | $256,046 | 13,685 | $0 | 0 | +13,685 | New Buy |
