| TCG Crossover Management, LLC |
| 0.48% | 0.62% | #5 | $20.1M | 10.0M | $21.5M | 10.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $15.8M | 7.8M | $16.6M | 7.7M | +106,634+1.38% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #21 | $8.9M | 4.4M | $8.7M | 4.0M | +375,560+9.30% | Add |
| Nantahala Capital Management, LLC |
| 0.29% | 0.22% | #12 | $8.7M | 4.3M | $6.1M | 2.8M | +1.5M+53.34% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $8.1M | 4.0M | $7.9M | 3.7M | +330,618+8.99% | Add |
| Kynam Capital Management, LP |
| 0.42% | 0.27% | #7 | $7.7M | 3.8M | $4.3M | 2.0M | +1.8M+90.42% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #23 | $7.5M | 3.8M | $6.3M | 2.9M | +816,073+27.80% | Add |
| Merck & Co., Inc. |
| 1.35% | 2.18% | #2 | $7.1M | 3.5M | $7.6M | 3.5M | 00.00% | Unchanged |
| 683 Capital Management, LLC |
| 0.32% | 0.36% | #10 | $6.4M | 3.2M | $6.9M | 3.2M | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #29 | $5.9M | 3.0M | $7.2M | 3.3M | -372,852-11.19% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.27% | 0.13% | #13 | $5.8M | 2.9M | $2.3M | 1.1M | +1.8M+174.63% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #58 | $5.7M | 2.8M | $5.6M | 2.6M | +236,951+9.17% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #57 | $4.9M | 2.5M | $4.9M | 2.3M | +168,053+7.35% | Add |
| Spruce Street Capital LP |
| 0.83% | 1.09% | #3 | $4.2M | 2.1M | $4.5M | 2.1M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $4.0M | 2.0M | $4.3M | 2.0M | +9,609+0.49% | Add |
| Ikarian Capital, LLC |
| 0.42% | 0.36% | #8 | $4.0M | 2.0M | $4.5M | 2.1M | -100,000-4.80% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #75 | $3.8M | 1.9M | $4.0M | 1.9M | +14,239+0.76% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #20 | $3.5M | 1.8M | $4.6M | 2.2M | -388,432-18.03% | Reduce |
| MEDICI CAPITAL LLC |
| 6.51% | 4.37% | #1 | $3.3M | 1.7M | $3.6M | 1.7M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.14% | 0.06% | #15 | $3.0M | 1.5M | $1.1M | 500,000 | +1.0M+202.00% | Add |
| Eversept Partners, LP |
| 0.15% | 0.15% | #14 | $2.9M | 1.4M | $2.9M | 1.4M | +72,767+5.39% | Add |
| FMR LLC |
| <0.01% | <0.01% | #72 | $2.8M | 1.4M | $3.9M | 1.8M | -399,706-22.25% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $2.6M | 1.3M | $1.5M | 711,334 | +598,243+84.10% | Add |
| Euclidean Capital LLC |
| 0.6% | 0.72% | #4 | $2.6M | 1.3M | $2.8M | 1.3M | 00.00% | Unchanged |
| MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #32 | $2.2M | 1.1M | $1.8M | 857,354 | +252,416+29.44% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #46 | $2.2M | 1.1M | $2.3M | 1.1M | +5,485+0.50% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.02% | 0.03% | #17 | $2.1M | 1.1M | $2.3M | 1.1M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $2.1M | 1.0M | $2.8M | 1.3M | -233,930-18.29% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $1.9M | 935,166 | $2.8M | 1.3M | -352,525-27.38% | Reduce |
| DAFNA Capital Management LLC |
| 0.35% | 0.44% | #9 | $1.8M | 908,351 | $2.0M | 908,351 | 00.00% | Unchanged |
| Elmind Capital, LP |
| 0.45% | 0.55% | #6 | $1.8M | 900,000 | $1.9M | 900,000 | 00.00% | Unchanged |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #25 | $1.7M | 845,999 | $1.3M | 590,388 | +255,611+43.30% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $1.6M | 818,831 | $1.7M | 787,408 | +31,423+3.99% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $1.6M | 773,462 | $1.5M | 692,256 | +81,206+11.73% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $1.3M | 663,592 | $1.2M | 577,939 | +85,653+14.82% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #40 | $1.2M | 598,559 | $1.3M | 620,424 | -21,865-3.52% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.02% | #19 | $1.1M | 532,850 | $1.2M | 559,726 | -26,876-4.80% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $1.0M | 500,132 | $234,877 | 109,245 | +390,887+357.81% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $872,089 | 433,875 | $1.3M | 604,562 | -170,687-28.23% | Reduce |
| XTX Topco Ltd |
| 0.01% | 0.02% | #22 | $803,359 | 399,681 | $1.2M | 559,896 | -160,215-28.62% | Reduce |
| CANTOR FITZGERALD, L. P. |
| 0.01% | — | #24 | $593,939 | 295,492 | $0 | 0 | +295,492 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #90 | $550,298 | 273,780 | $312,490 | 145,344 | +128,436+88.37% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #99 | $516,849 | 257,139 | $569,893 | 265,067 | -7,928-2.99% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $502,688 | 250,093 | $542,440 | 252,297 | -2,204-0.87% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #81 | $451,305 | 224,530 | $583,234 | 271,272 | -46,742-17.23% | Reduce |
| LMR Partners LLP |
| <0.01% | — | #35 | $402,000 | 200,000 | $0 | 0 | +200,000 | New Buy |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.31% | 0.4% | #11 | $402,000 | 200,000 | $430,000 | 200,000 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #83 | $354,230 | 176,234 | $333,100 | 154,930 | +21,304+13.75% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #108 | $346,570 | 172,423 | $578,989 | 269,297 | -96,874-35.97% | Reduce |
| Utah Retirement Systems |
| <0.01% | <0.01% | #28 | $310,123 | 154,290 | $331,724 | 154,290 | 00.00% | Unchanged |
