| BlackRock, Inc. |
| <0.01% | <0.01% | #108 | $62.9M | 49.1M | $70.5M | 47.3M | +1.8M+3.80% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.48% | 1.01% | #10 | $54.8M | 42.8M | $95.0M | 63.8M | -21.0M-32.87% | Reduce |
| Soleus Capital Management, L.P. |
| 1.89% | 2.5% | #2 | $54.8M | 42.8M | $61.8M | 41.5M | +1.3M+3.13% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #97 | $45.9M | 35.9M | $45.4M | 30.5M | +5.4M+17.57% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #64 | $37.8M | 29.6M | $32.9M | 22.1M | +7.4M+33.66% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #119 | $34.9M | 27.3M | $39.7M | 26.7M | +581,186+2.18% | Add |
| Clearbridge Investments, LLC |
| 0.02% | 0.03% | #38 | $25.2M | 19.6M | $29.2M | 19.6M | +28,533+0.15% | Add |
| Eversept Partners, LP |
| 1.24% | 1.48% | #3 | $24.0M | 18.7M | $28.1M | 18.8M | -117,461-0.62% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $21.3M | 16.6M | $16.7M | 11.2M | +5.5M+48.82% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #106 | $18.6M | 14.6M | $20.4M | 13.7M | +885,169+6.47% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $16.6M | 12.9M | $14.7M | 10.7M | +2.2M+21.00% | Add |
| Nantahala Capital Management, LLC |
| 0.52% | 0.62% | #6 | $15.6M | 12.2M | $16.7M | 11.2M | +1.0M+8.91% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $13.8M | 10.8M | $7.0M | 4.7M | +6.1M+131.59% | Add |
| Vivo Capital, LLC |
| 1.01% | 1.07% | #4 | $11.1M | 8.7M | $12.9M | 8.7M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #70 | $10.4M | 8.1M | $10.9M | 7.3M | +790,745+10.80% | Add |
| Kynam Capital Management, LP |
| 0.48% | 0.63% | #8 | $8.8M | 6.8M | $10.2M | 6.8M | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.03% | 0.02% | #24 | $7.1M | 5.6M | $3.7M | 2.8M | +2.7M+96.84% | Add |
| FMR LLC |
| <0.01% | <0.01% | #151 | $7.0M | 5.5M | $9.8M | 6.6M | -1.1M-16.59% | Reduce |
| Pale Fire Capital SE |
| 0.48% | 0.64% | #9 | $6.8M | 5.3M | $7.3M | 4.9M | +418,900+8.57% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $6.4M | 5.0M | $7.2M | 4.9M | +169,948+3.50% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #115 | $6.3M | 4.9M | $5.5M | 3.7M | +1.2M+32.57% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #51 | $5.9M | 4.6M | $2.7M | 1.8M | +2.8M+154.46% | Add |
| SEGALL BRYANT & HAMILL, LLC |
| 0.07% | 0.1% | #16 | $5.7M | 4.5M | $7.1M | 4.7M | -254,494-5.37% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #67 | $5.5M | 4.3M | $2.8M | 1.9M | +2.4M+128.00% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #121 | $5.5M | 4.3M | $6.7M | 4.5M | -198,714-4.43% | Reduce |
| TORONTO DOMINION BANK |
| 0.01% | <0.01% | #58 | $5.4M | 4.2M | $190,289 | 127,711 | +4.1M+3,216.08% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.04% | #60 | $5.2M | 4.0M | $30.5M | 20.5M | -16.4M-80.23% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #103 | $5.1M | 4.0M | $5.7M | 3.8M | +128,417+3.35% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #154 | $4.5M | 3.5M | $6.8M | 4.6M | -1.0M-22.43% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #98 | $4.4M | 3.4M | $7.8M | 5.2M | -1.8M-33.89% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #66 | $4.3M | 3.4M | $2.2M | 1.4M | +1.9M+132.50% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #42 | $3.8M | 2.9M | $537,659 | 360,845 | +2.6M+714.61% | Add |
| ExodusPoint Capital Management, LP |
| 0.02% | — | #37 | $3.2M | 2.5M | $0 | 0 | +2.5M | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #93 | $3.1M | 2.4M | $635,780 | 426,698 | +2.0M+466.31% | Add |
| EDMOND DE ROTHSCHILD HOLDING S.A. |
| 0.04% | 0.05% | #21 | $3.0M | 2.3M | $3.5M | 2.3M | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #171 | $2.9M | 2.2M | $3.5M | 2.4M | -116,678-4.93% | Reduce |
| NAN FUNG TRINITY (HK) Ltd |
| 0.28% | 0.22% | #12 | $2.8M | 2.2M | $2.0M | 1.4M | +850,000+61.88% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #148 | $2.1M | 1.6M | $2.3M | 1.5M | +78,010+5.06% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #140 | $2.0M | 1.5M | $4.4M | 2.9M | -1.4M-47.25% | Reduce |
| World Investment Advisors |
| 0.03% | 0.02% | #29 | $1.5M | 1.0M | $1.5M | 1.0M | 00.00% | Unchanged |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.02% | — | #33 | $1.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Invesco Ltd. |
| <0.01% | <0.01% | #191 | $1.5M | 1.2M | $1.9M | 1.3M | -129,250-9.91% | Reduce |
| Seven Fleet Capital Management LP |
| 0.22% | 0.2% | #13 | $1.4M | 1.1M | $632,028 | 424,180 | +633,048+149.24% | Add |
| Virtus Investment Advisers, LLC |
| 0.3% | 0.26% | #11 | $1.3M | 1.0M | $924,985 | 620,795 | +390,406+62.89% | Add |
| Voleon Capital Management LP |
| 0.02% | <0.01% | #32 | $1.3M | 1.0M | $182,692 | 122,612 | +882,376+719.65% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | 0.02% | #23 | $1.3M | 1.0M | $590,982 | 396,632 | +604,278+152.35% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #167 | $1.3M | 983,698 | $1.9M | 1.3M | -287,316-22.61% | Reduce |
| Swiss National Bank |
| <0.01% | <0.01% | #126 | $1.2M | 964,000 | $1.4M | 947,500 | +16,500+1.74% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #147 | $1.1M | 826,216 | $943,917 | 633,501 | +192,715+30.42% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #123 | $937,030 | 732,065 | $1.0M | 700,101 | +31,964+4.57% | Add |
