| Deep Track Capital, LP |
| 1.58% | 1.35% | #8 | $108.8M | 3.4M | $82.7M | 3.4M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $88.7M | 2.7M | $60.9M | 2.5M | +263,460+10.66% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.62% | 0.58% | #15 | $71.7M | 2.2M | $54.5M | 2.2M | 00.00% | Unchanged |
| Trails Edge Capital Partners, LP |
| 7.85% | 7.45% | #3 | $49.4M | 1.5M | $32.5M | 1.3M | +203,660+15.44% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #42 | $48.9M | 1.5M | $33.2M | 1.4M | +69,725+4.88% | Add |
| Commodore Capital LP |
| 2.9% | 2.14% | #4 | $48.7M | 1.5M | $37.0M | 1.5M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 1.13% | 1.3% | #11 | $47.0M | 1.4M | $45.3M | 1.8M | -392,179-21.32% | Reduce |
| Caligan Partners LP |
| 2.2% | 2.3% | #6 | $46.7M | 1.4M | $34.6M | 1.4M | 00.00% | Unchanged |
| Spruce Street Capital LP |
| 8.76% | 8.09% | #2 | $44.7M | 1.4M | $33.6M | 1.4M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 1.14% | 0.96% | #10 | $34.2M | 1.1M | $26.0M | 1.1M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $31.5M | 971,165 | $22.1M | 894,653 | +76,512+8.55% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.03% | #28 | $29.9M | 921,471 | $22.8M | 923,694 | -2,223-0.24% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.07% | 0.06% | #26 | $28.0M | 863,947 | $21.3M | 863,947 | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 2.37% | 1.64% | #5 | $26.0M | 800,000 | $19.7M | 800,000 | 00.00% | Unchanged |
| Nan Fung Group Holdings Ltd |
| 15.57% | 12.82% | #1 | $20.5M | 630,657 | $15.6M | 630,657 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $19.9M | 612,793 | $12.8M | 518,228 | +94,565+18.25% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $19.5M | 602,028 | $12.4M | 504,373 | +97,655+19.36% | Add |
| Logos Global Management LP |
| 0.82% | 1.13% | #13 | $19.0M | 585,000 | $22.6M | 915,000 | -330,000-36.07% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #47 | $18.7M | 576,456 | $9.0M | 363,799 | +212,657+58.45% | Add |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #35 | $17.6M | 540,902 | $13.3M | 538,216 | +2,686+0.50% | Add |
| GREAT POINT PARTNERS LLC |
| 1.95% | 1.7% | #7 | $10.3M | 317,221 | $7.4M | 300,000 | +17,221+5.74% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.12% | — | #23 | $8.9M | 275,675 | $0 | 0 | +275,675 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $8.4M | 259,219 | $3.4M | 136,966 | +122,253+89.26% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #48 | $7.4M | 227,485 | $2.7M | 108,307 | +119,178+110.04% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $7.0M | 215,969 | $10.3M | 416,906 | -200,937-48.20% | Reduce |
| HighVista Strategies LLC |
| 1.57% | 1.18% | #9 | $6.9M | 211,511 | $4.3M | 173,595 | +37,916+21.84% | Add |
| BAKER BROS. ADVISORS LP |
| 0.03% | 0.03% | #29 | $6.5M | 200,000 | $4.9M | 200,000 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $6.3M | 195,486 | $4.6M | 186,095 | +9,391+5.05% | Add |
| FMR LLC |
| <0.01% | <0.01% | #81 | $6.1M | 188,907 | $5.5M | 222,508 | -33,601-15.10% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $6.0M | 186,037 | $3.8M | 154,398 | +31,639+20.49% | Add |
| Eversept Partners, LP |
| 0.31% | 0.13% | #17 | $6.0M | 183,663 | $2.5M | 100,198 | +83,465+83.30% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $5.3M | 162,801 | $3.9M | 157,426 | +5,375+3.41% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $4.9M | 152,162 | $2.8M | 112,497 | +39,665+35.26% | Add |
| Integral Health Asset Management, LLC |
| 0.19% | 0.18% | #20 | $4.9M | 150,000 | $3.7M | 150,000 | 00.00% | Unchanged |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #58 | $3.0M | 91,656 | $0 | 0 | +91,656 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #50 | $2.8M | 86,371 | $99,922 | 4,052 | +82,319+2,031.56% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #75 | $2.8M | 85,951 | $3.4M | 137,932 | -51,981-37.69% | Reduce |
| Longbow Finance SA |
| 0.34% | — | #16 | $2.7M | 82,336 | $0 | 0 | +82,336 | New Buy |
| Boxer Capital Management, LLC |
| 0.17% | 0.23% | #21 | $2.3M | 70,000 | $1.7M | 70,000 | 00.00% | Unchanged |
| NEXTBio Capital Management LP |
| 1.02% | — | #12 | $2.2M | 68,249 | $0 | 0 | +68,249 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #78 | $1.9M | 58,891 | $1.3M | 52,640 | +6,251+11.88% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #80 | $1.8M | 54,979 | $1.1M | 45,457 | +9,522+20.95% | Add |
| ALERUS FINANCIAL NA |
| 0.08% | — | #25 | $1.8M | 54,891 | $0 | 0 | +54,891 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #70 | $1.7M | 52,142 | $566,342 | 22,966 | +29,176+127.04% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $1.7M | 51,207 | $151,663 | 9,605 | +41,602+433.13% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #53 | $1.6M | 48,652 | $313,675 | 12,720 | +35,932+282.48% | Add |
| XTX Topco Ltd |
| 0.02% | — | #32 | $1.5M | 47,006 | $0 | 0 | +47,006 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| 0.03% | — | #31 | $1.3M | 39,413 | $0 | 0 | +39,413 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #56 | $1.1M | 34,074 | $1.8M | 72,067 | -37,993-52.72% | Reduce |
| STEMPOINT CAPITAL LP |
| 0.15% | 0.23% | #22 | $1.0M | 31,785 | $1.2M | 50,000 | -18,215-36.43% | Reduce |
