| JENNISON ASSOCIATES LLC |
| 0.04% | 0.02% | #21 | $62.3M | 20.0M | $24.1M | 9.0M | +11.1M+123.33% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #20 | $58.7M | 18.9M | $29.8M | 11.1M | +7.8M+70.31% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 3.19% | 2.35% | #1 | $53.6M | 17.2M | $26.0M | 9.7M | +7.6M+78.17% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #80 | $33.4M | 10.8M | $6.4M | 2.4M | +8.4M+353.21% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.04% | #18 | $28.5M | 9.2M | $23.8M | 8.8M | +345,000+3.91% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #69 | $24.4M | 7.8M | $1.3M | 469,978 | +7.4M+1,568.02% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $22.5M | 7.2M | $10.8M | 4.0M | +3.2M+79.38% | Add |
| Cormorant Asset Management, LP |
| 0.79% | 0.74% | #5 | $15.6M | 5.0M | $14.8M | 5.5M | -500,000-9.09% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #58 | $13.7M | 4.4M | $1.2M | 442,277 | +4.0M+899.07% | Add |
| Woodline Partners LP |
| 0.04% | 0.01% | #17 | $13.1M | 4.2M | $3.4M | 1.3M | +2.9M+235.95% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #56 | $12.9M | 4.1M | $1.5M | 560,800 | +3.6M+636.95% | Add |
| NORGES BANK |
| <0.01% | — | #59 | $12.8M | 4.1M | $0 | 0 | +4.1M | New Buy |
| Opaleye Management Inc. |
| 1.09% | 0.49% | #4 | $12.0M | 3.9M | $3.7M | 1.4M | +2.5M+179.99% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $10.8M | 3.5M | $3.0M | 1.1M | +2.3M+205.27% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #70 | $9.1M | 2.9M | $3.0M | 1.1M | +1.8M+162.48% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #55 | $7.5M | 2.4M | $0 | 0 | +2.4M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $6.9M | 2.2M | $2.8M | 1.0M | +1.2M+114.80% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #49 | $6.4M | 2.1M | $15.9M | 5.9M | -3.8M-64.96% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #45 | $4.9M | 1.6M | $5.9M | 2.2M | -613,879-28.16% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $4.8M | 1.5M | $5.5M | 2.0M | -501,363-24.62% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #75 | $4.6M | 1.5M | $1.6M | 606,664 | +865,231+142.62% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | 0.01% | #44 | $4.4M | 1.4M | $5.2M | 1.9M | -508,150-26.26% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #95 | $4.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #47 | $4.4M | 1.4M | $6.7M | 2.5M | -1.1M-43.52% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $4.2M | 1.3M | $3.5M | 1.5M | -129,150-8.76% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.54% | — | #7 | $4.1M | 1.3M | $0 | 0 | +1.3M | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 2.19% | 2.05% | #2 | $3.5M | 1.3M | $2.9M | 1.1M | +212,413+19.92% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $3.4M | 1.1M | $1.5M | 570,191 | +518,404+90.92% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #87 | $3.1M | 1.0M | $641,409 | 238,442 | +768,660+322.37% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #78 | $3.0M | 967,195 | $2.0M | 740,648 | +226,547+30.59% | Add |
| Stonepine Capital Management, LLC |
| 0.44% | 0.05% | #8 | $2.9M | 917,100 | $134,500 | 50,000 | +867,100+1,734.20% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #52 | $2.7M | 856,637 | $1.9M | 756,637 | +100,000+13.22% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #79 | $2.6M | 828,145 | $0 | 0 | +828,145 | New Buy |
| CANTOR FITZGERALD, L. P. |
| 0.03% | 0.03% | #22 | $2.5M | 800,001 | $2.1M | 765,000 | +35,001+4.58% | Add |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.54% | — | #6 | $2.3M | 755,626 | $0 | 0 | +755,626 | New Buy |
| Blue Owl Capital Holdings LP |
| 0.32% | — | #9 | $2.2M | 714,710 | $0 | 0 | +714,710 | New Buy |
| Ikarian Capital, LLC |
| 0.23% | 0.2% | #10 | $2.2M | 700,000 | $2.4M | 900,000 | -200,000-22.22% | Reduce |
| Burkehill Global Management, LP |
| 0.08% | 0.09% | #15 | $2.2M | 700,000 | $1.9M | 700,000 | 00.00% | Unchanged |
| GSA CAPITAL PARTNERS LLP |
| 0.13% | 0.09% | #11 | $2.1M | 668,563 | $1.5M | 561,726 | +106,837+19.02% | Add |
| Nuveen, LLC |
| <0.01% | — | #82 | $2.0M | 646,345 | $0 | 0 | +646,345 | New Buy |
| Caption Management, LLC |
| 0.01% | <0.01% | #30 | $1.9M | 599,500 | $269,000 | 100,000 | +499,500+499.50% | Add |
| KVP Capital Advisors, LP |
| 1.15% | 1.02% | #3 | $1.6M | 505,431 | $1.4M | 505,431 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #64 | $1.5M | 497,900 | $1.1M | 410,000 | +87,900+21.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #109 | $1.5M | 493,314 | $724,301 | 269,257 | +224,057+83.21% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #103 | $1.5M | 492,800 | $1.1M | 423,694 | +69,106+16.31% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #51 | $1.5M | 490,200 | $2.4M | 905,800 | -415,600-45.88% | Reduce |
| Jump Financial, LLC |
| 0.01% | <0.01% | #28 | $1.5M | 488,775 | $44,923 | 16,700 | +472,075+2,826.80% | Add |
| Raiffeisen Bank International AG |
| 0.02% | 0.02% | #26 | $1.3M | 430,000 | $1.1M | 450,000 | -20,000-4.44% | Reduce |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $1.2M | 391,472 | $180,026 | 66,924 | +324,548+484.95% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | <0.01% | #24 | $1.2M | 383,294 | $47,331 | 17,595 | +365,699+2,078.43% | Add |
