| ARCH Venture Management, LLC |
| 12.42% | — | #2 | $136.6M | 6.3M | $0 | 0 | +6.3M | New Buy |
| GENERAL ATLANTIC, L.P. |
| 4.56% | — | #4 | $132.5M | 6.1M | $0 | 0 | +6.1M | New Buy |
| Sofinnova Investments, Inc. |
| 4% | — | #5 | $77.4M | 3.6M | $0 | 0 | +3.6M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #26 | $47.3M | 2.2M | $0 | 0 | +2.2M | New Buy |
| TRV GP VI, LLC |
| 19.27% | — | #1 | $44.8M | 2.1M | $0 | 0 | +2.1M | New Buy |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.02% | — | #17 | $42.9M | 2.0M | $0 | 0 | +2.0M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #31 | $40.9M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Foresite Capital Management VI LLC |
| 6.02% | — | #3 | $38.7M | 1.8M | $0 | 0 | +1.8M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #29 | $28.4M | 1.3M | $0 | 0 | +1.3M | New Buy |
| FMR LLC |
| <0.01% | — | #33 | $25.7M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Bellevue Group AG |
| 0.5% | — | #6 | $23.9M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Siren, L.L.C. |
| 0.48% | — | #8 | $23.8M | 1.1M | $0 | 0 | +1.1M | New Buy |
| JENNISON ASSOCIATES LLC |
| 0.01% | — | #19 | $23.5M | 1.1M | $0 | 0 | +1.1M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.13% | — | #13 | $15.2M | 700,000 | $0 | 0 | +700,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #43 | $13.0M | 599,217 | $0 | 0 | +599,217 | New Buy |
| Woodline Partners LP |
| 0.04% | — | #15 | $12.7M | 586,345 | $0 | 0 | +586,345 | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 0.16% | — | #11 | $10.9M | 500,000 | $0 | 0 | +500,000 | New Buy |
| BRAIDWELL LP |
| 0.4% | — | #9 | $10.9M | 500,000 | $0 | 0 | +500,000 | New Buy |
| PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | — | #24 | $9.0M | 414,672 | $0 | 0 | +414,672 | New Buy |
| Aberdeen Group plc |
| 0.01% | — | #21 | $6.7M | 310,355 | $0 | 0 | +310,355 | New Buy |
| UBS Group AG |
| <0.01% | — | #35 | $6.1M | 279,184 | $0 | 0 | +279,184 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #46 | $5.0M | 229,863 | $0 | 0 | +229,863 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.2% | — | #10 | $4.9M | 225,000 | $0 | 0 | +225,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $4.2M | 191,144 | $0 | 0 | +191,144 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #44 | $3.8M | 175,866 | $0 | 0 | +175,866 | New Buy |
| Pier Capital, LLC |
| 0.49% | — | #7 | $3.7M | 169,985 | $0 | 0 | +169,985 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #37 | $2.9M | 131,788 | $0 | 0 | +131,788 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #42 | $2.1M | 97,693 | $0 | 0 | +97,693 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #39 | $1.9M | 87,772 | $0 | 0 | +87,772 | New Buy |
| Pentwater Capital Management LP |
| 0.01% | — | #20 | $1.8M | 83,000 | $0 | 0 | +83,000 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #32 | $1.8M | 82,565 | $0 | 0 | +82,565 | New Buy |
| Alyeska Investment Group, L.P. |
| <0.01% | — | #25 | $1.6M | 75,000 | $0 | 0 | +75,000 | New Buy |
| ALPS ADVISORS INC |
| 0.01% | — | #22 | $1.2M | 54,328 | $0 | 0 | +54,328 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #34 | $1.0M | 47,944 | $0 | 0 | +47,944 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #41 | $984,720 | 45,337 | $0 | 0 | +45,337 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.05% | — | #14 | $720,626 | 33,178 | $0 | 0 | +33,178 | New Buy |
| DAFNA Capital Management LLC |
| 0.13% | — | #12 | $703,728 | 32,400 | $0 | 0 | +32,400 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #45 | $690,739 | 31,802 | $0 | 0 | +31,802 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.03% | — | #16 | $564,720 | 26,000 | $0 | 0 | +26,000 | New Buy |
| Ghisallo Capital Management LLC |
| <0.01% | — | #27 | $543,000 | 25,000 | $0 | 0 | +25,000 | New Buy |
| Burkehill Global Management, LP |
| 0.02% | — | #18 | $543,000 | 25,000 | $0 | 0 | +25,000 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #36 | $537,635 | 24,753 | $0 | 0 | +24,753 | New Buy |
| HighTower Advisors, LLC |
| <0.01% | — | #40 | $361,986 | 16,666 | $0 | 0 | +16,666 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #51 | $253,951 | 11,692 | $0 | 0 | +11,692 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #28 | $238,551 | 10,983 | $0 | 0 | +10,983 | New Buy |
| Weiss Asset Management LP |
| <0.01% | — | #30 | $217,200 | 10,000 | $0 | 0 | +10,000 | New Buy |
| Zimmer Partners, LP |
| 0.01% | — | #23 | $217,200 | 10,000 | $0 | 0 | +10,000 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #52 | $197,239 | 9,081 | $0 | 0 | +9,081 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | — | #47 | $155,493 | 7,159 | $0 | 0 | +7,159 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #50 | $53,301 | 2,454 | $0 | 0 | +2,454 | New Buy |
