| MONTANOVA CAPITAL, LLC |
| 0.54% | 0.18% | #4 | $29.7M | 6.4M | $7.2M | 1.3M | +5.1M+410.74% | Add |
| Affinity Asset Advisors, LLC |
| 1.22% | 1.5% | #2 | $27.0M | 5.8M | $29.0M | 5.1M | +757,400+15.00% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #66 | $26.7M | 5.7M | $29.3M | 5.1M | +628,584+12.30% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.2% | 0.3% | #13 | $23.3M | 5.0M | $28.7M | 5.0M | 00.00% | Unchanged |
| Frazier Life Sciences Management, L.P. |
| 0.49% | 0.65% | #5 | $22.5M | 4.8M | $25.4M | 4.4M | +400,000+9.04% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #58 | $20.3M | 4.4M | $20.5M | 3.6M | +786,515+22.04% | Add |
| Vestal Point Capital, LP |
| 0.47% | 0.72% | #6 | $20.1M | 4.3M | $25.7M | 4.5M | -155,000-3.46% | Reduce |
| Paradigm Biocapital Advisors LP |
| 0.36% | 0.73% | #8 | $19.4M | 4.2M | $35.5M | 6.2M | -2.0M-32.48% | Reduce |
| Jupiter Topco LLC |
| 0.01% | — | #32 | $18.4M | 4.0M | $0 | 0 | +4.0M | New Buy |
| ORBIMED ADVISORS LLC |
| 0.35% | 0.41% | #9 | $18.4M | 3.9M | $20.7M | 3.6M | +345,400+9.59% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #42 | $18.1M | 3.9M | $22.1M | 3.8M | +52,871+1.37% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $14.6M | 3.1M | $17.3M | 3.0M | +118,800+3.95% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $13.2M | 2.8M | $9.3M | 1.6M | +1.2M+75.70% | Add |
| Woodline Partners LP |
| 0.04% | 0.06% | #22 | $11.6M | 2.5M | $15.8M | 2.8M | -250,000-9.09% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #26 | $11.2M | 2.4M | $9.1M | 1.6M | +823,157+51.78% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $10.0M | 2.1M | $11.2M | 1.9M | +199,727+10.24% | Add |
| 683 Capital Management, LLC |
| 0.43% | 0.36% | #7 | $8.7M | 1.9M | $6.9M | 1.2M | +675,000+56.25% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $8.1M | 1.7M | $8.7M | 1.5M | +234,182+15.47% | Add |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.5% | #10 | $7.3M | 1.6M | $8.4M | 1.5M | +98,600+6.72% | Add |
| Avoro Capital Advisors LLC |
| 0.06% | 0.11% | #21 | $6.9M | 1.5M | $10.8M | 1.9M | -385,811-20.58% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #35 | $6.4M | 1.4M | $2.7M | 465,515 | +910,707+195.63% | Add |
| Nantahala Capital Management, LLC |
| 0.2% | 0.25% | #14 | $6.1M | 1.3M | $6.9M | 1.2M | +100,000+8.33% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #46 | $6.0M | 1.3M | $6.3M | 1.1M | +183,601+16.64% | Add |
| Spruce Street Capital LP |
| 0.85% | 1.28% | #3 | $4.3M | 928,593 | $5.3M | 928,593 | 00.00% | Unchanged |
| Blackstone Inc. |
| 0.01% | 0.02% | #27 | $4.2M | 904,959 | $5.2M | 904,959 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #60 | $4.0M | 867,391 | $2.8M | 493,666 | +373,725+75.70% | Add |
| Aberdeen Group plc |
| <0.01% | <0.01% | #38 | $3.1M | 675,092 | $1.4M | 245,904 | +429,188+174.53% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $2.9M | 613,826 | $3.3M | 577,192 | +36,634+6.35% | Add |
| Ikarian Capital, LLC |
| 0.25% | 0.24% | #12 | $2.4M | 513,011 | $2.9M | 513,011 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $2.3M | 490,331 | $2.8M | 491,532 | -1,201-0.24% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #62 | $2.0M | 430,696 | $2.2M | 384,734 | +45,962+11.95% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #97 | $1.8M | 395,102 | $651,097 | 98,057 | +297,045+302.93% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $1.8M | 388,398 | $1.3M | 228,201 | +160,197+70.20% | Add |
| DAFNA Capital Management LLC |
| 0.33% | 0.49% | #11 | $1.8M | 377,059 | $2.2M | 377,059 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #74 | $1.6M | 354,044 | $1.8M | 321,737 | +32,307+10.04% | Add |
| Trexquant Investment LP |
| 0.01% | — | #30 | $1.5M | 314,891 | $0 | 0 | +314,891 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #44 | $1.4M | 294,774 | $1.8M | 319,090 | -24,316-7.62% | Reduce |
| Hennion & Walsh Asset Management, Inc. |
| 0.04% | — | #23 | $1.2M | 265,697 | $0 | 0 | +265,697 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $1.2M | 256,661 | $1.9M | 339,623 | -82,962-24.43% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #43 | $1.2M | 250,365 | $0 | 0 | +250,365 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #77 | $942,093 | 202,383 | $991,315 | 172,703 | +29,680+17.19% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #72 | $932,941 | 200,417 | $1.1M | 182,975 | +17,442+9.53% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $855,975 | 183,883 | $912,080 | 158,899 | +24,984+15.72% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $803,495 | 172,609 | $1.0M | 182,069 | -9,460-5.20% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | 0.01% | #28 | $749,744 | 161,062 | $648,517 | 112,982 | +48,080+42.56% | Add |
| Privium Fund Management B.V. |
| 0.13% | 0.24% | #17 | $722,300 | 155,000 | $1.2M | 205,000 | -50,000-24.39% | Reduce |
| XTX Topco Ltd |
| 0.01% | 0.01% | #29 | $677,563 | 145,556 | $577,484 | 100,607 | +44,949+44.68% | Add |
| FMR LLC |
| <0.01% | <0.01% | #115 | $657,035 | 141,146 | $139,987 | 24,388 | +116,758+478.75% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #31 | $634,835 | 136,377 | $782,804 | 136,377 | 00.00% | Unchanged |
| Burkehill Global Management, LP |
| 0.02% | 0.04% | #25 | $581,875 | 125,000 | $717,500 | 125,000 | 00.00% | Unchanged |
