| Flagship Pioneering, LLC |
| 68.66% | 67.44% | #1 | $1.06B | 62.7M | $783.4M | 62.7M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #29 | $88.1M | 5.2M | $52.7M | 4.2M | +1.0M+23.81% | Add |
| Capital World Investors |
| 0.01% | 0.01% | #21 | $71.1M | 4.2M | $50.1M | 4.0M | +211,483+5.28% | Add |
| BRAIDWELL LP |
| 2.05% | 1.5% | #5 | $55.4M | 3.3M | $44.9M | 3.6M | -309,155-8.60% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #30 | $36.4M | 2.2M | $26.4M | 2.1M | +46,994+2.23% | Add |
| NORGES BANK |
| <0.01% | — | #31 | $35.3M | 2.1M | $0 | 0 | +2.1M | New Buy |
| ARCH Venture Management, LLC |
| 2.98% | 3.59% | #3 | $32.8M | 1.9M | $24.3M | 1.9M | 00.00% | Unchanged |
| HARBOURVEST PARTNERS LLC |
| 17.09% | 21.33% | #2 | $29.1M | 1.7M | $21.5M | 1.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | — | #48 | $28.0M | 1.7M | $0 | 0 | +1.7M | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.12% | 0.1% | #12 | $24.0M | 1.4M | $17.8M | 1.4M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #34 | $23.8M | 1.4M | $33.9M | 2.9M | -1.5M-52.17% | Reduce |
| Deep Track Capital, LP |
| 0.33% | — | #8 | $22.5M | 1.3M | $0 | 0 | +1.3M | New Buy |
| ARK Investment Management LLC |
| 0.14% | 0.05% | #11 | $21.7M | 1.3M | $6.2M | 498,408 | +786,209+157.74% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $19.1M | 1.1M | $1.6M | 131,319 | +1.0M+762.59% | Add |
| HARVARD MANAGEMENT CO INC |
| 0.44% | 0.76% | #7 | $18.7M | 1.1M | $13.9M | 1.1M | 00.00% | Unchanged |
| NVIDIA CORP |
| 0.02% | 0.06% | #18 | $14.1M | 833,325 | $10.4M | 833,325 | 00.00% | Unchanged |
| Davern Capital Partners, LP |
| 2.37% | 2.03% | #4 | $13.9M | 824,679 | $7.4M | 591,800 | +232,879+39.35% | Add |
| Siren, L.L.C. |
| 0.25% | 0.26% | #10 | $12.4M | 736,104 | $9.2M | 736,104 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $12.4M | 735,003 | $1.5M | 118,243 | +616,760+521.60% | Add |
| STATE STREET CORP |
| <0.01% | — | #57 | $8.9M | 526,565 | $0 | 0 | +526,565 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.3% | 0.23% | #9 | $6.7M | 400,000 | $4.4M | 350,000 | +50,000+14.29% | Add |
| MORGAN STANLEY |
| <0.01% | — | #54 | $6.4M | 377,994 | $0 | 0 | +377,994 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #41 | $5.5M | 326,273 | $4.5M | 356,704 | -30,431-8.53% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.54% | 0.37% | #6 | $4.1M | 245,000 | $2.3M | 185,000 | +60,000+32.43% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #46 | $3.8M | 224,602 | $0 | 0 | +224,602 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #51 | $3.3M | 197,543 | $0 | 0 | +197,543 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #43 | $3.0M | 175,356 | $218,200 | 17,456 | +157,900+904.56% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #66 | $2.8M | 167,285 | $0 | 0 | +167,285 | New Buy |
| CenterBook Partners LP |
| 0.11% | 0.18% | #13 | $2.2M | 131,560 | $3.3M | 266,813 | -135,253-50.69% | Reduce |
| ALPS ADVISORS INC |
| 0.01% | — | #20 | $2.2M | 129,406 | $0 | 0 | +129,406 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.08% | 0.1% | #15 | $2.1M | 125,000 | $1.6M | 125,000 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #53 | $2.0M | 116,902 | $886,175 | 70,894 | +46,008+64.90% | Add |
| LMR Partners LLP |
| 0.01% | <0.01% | #24 | $1.7M | 100,000 | $1.3M | 100,000 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #55 | $1.5M | 91,100 | $1.1M | 87,335 | +3,765+4.31% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #36 | $1.4M | 84,803 | $928,900 | 74,312 | +10,491+14.12% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #64 | $967,090 | 57,326 | $0 | 0 | +57,326 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $935,104 | 55,430 | $427,450 | 34,196 | +21,234+62.09% | Add |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #40 | $856,119 | 50,748 | $535,825 | 42,866 | +7,882+18.39% | Add |
| Nuveen, LLC |
| <0.01% | — | #61 | $750,209 | 44,470 | $0 | 0 | +44,470 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #38 | $669,486 | 39,685 | $0 | 0 | +39,685 | New Buy |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #52 | $652,279 | 38,665 | $504,300 | 40,344 | -1,679-4.16% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.01% | 0.01% | #22 | $644,355 | 38,218 | $499,459 | 40,344 | -2,126-5.27% | Reduce |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.04% | 0.02% | #16 | $628,003 | 37,226 | $240,038 | 19,203 | +18,023+93.86% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #28 | $531,574 | 31,510 | $0 | 0 | +31,510 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #45 | $529,819 | 31,406 | $465,038 | 37,203 | -5,797-15.58% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | — | #50 | $517,025 | 30,648 | $0 | 0 | +30,648 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #63 | $516,003 | 30,587 | $28,050 | 2,244 | +28,343+1,263.06% | Add |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #14 | $445,874 | 26,430 | $0 | 0 | +26,430 | New Buy |
| XTX Topco Ltd |
| 0.01% | — | #26 | $421,008 | 24,956 | $0 | 0 | +24,956 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #69 | $407,157 | 24,135 | $0 | 0 | +24,135 | New Buy |
