| Caligan Partners LP |
| 1.45% | 1.84% | #9 | $30.9M | 8.2M | $27.6M | 5.0M | +3.2M+64.09% | Add |
| Samsara BioCapital, LLC |
| 1.96% | 2.8% | #7 | $23.9M | 6.3M | $28.8M | 5.2M | +1.1M+21.56% | Add |
| Paradigm Biocapital Advisors LP |
| 0.28% | 0.45% | #20 | $15.1M | 4.0M | $22.2M | 4.0M | 00.00% | Unchanged |
| Andera Partners |
| 6.65% | 5.7% | #1 | $13.7M | 3.6M | $10.1M | 1.8M | +1.8M+99.83% | Add |
| ADAR1 Capital Management, LLC |
| 0.63% | 0.71% | #14 | $13.6M | 3.6M | $12.1M | 2.2M | +1.4M+65.87% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #45 | $13.3M | 3.5M | $16.6M | 3.0M | +524,561+17.56% | Add |
| Nantahala Capital Management, LLC |
| 0.34% | — | #18 | $10.2M | 2.7M | $0 | 0 | +2.7M | New Buy |
| Trails Edge Capital Partners, LP |
| 1.6% | 3.38% | #8 | $10.0M | 2.7M | $14.8M | 2.7M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #49 | $10.0M | 2.6M | $13.7M | 2.5M | +181,046+7.35% | Add |
| Squadron Capital Management LLC |
| 2.86% | 1.09% | #4 | $9.2M | 2.4M | $3.0M | 535,000 | +1.9M+355.14% | Add |
| Woodline Partners LP |
| 0.03% | — | #33 | $8.8M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Aberdeen Group plc |
| 0.01% | — | #35 | $8.7M | 2.3M | $0 | 0 | +2.3M | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #57 | $8.7M | 2.3M | $12.9M | 2.3M | -13,501-0.58% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.1% | 0.11% | #24 | $7.6M | 2.0M | $8.2M | 1.5M | +533,375+36.27% | Add |
| Patient Square Capital LP |
| 1.15% | — | #10 | $7.4M | 2.0M | $0 | 0 | +2.0M | New Buy |
| NEXTBio Capital Management LP |
| 3.11% | 3.44% | #3 | $6.8M | 1.8M | $7.4M | 1.3M | +454,500+34.08% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #61 | $6.7M | 1.8M | $360,473 | 64,950 | +1.7M+2,647.60% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #55 | $6.4M | 1.7M | $4.7M | 844,215 | +852,933+101.03% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #39 | $6.4M | 1.7M | $5.3M | 956,221 | +726,791+76.01% | Add |
| Integral Health Asset Management, LLC |
| 0.23% | 0.11% | #22 | $5.7M | 1.5M | $2.2M | 400,000 | +1.1M+280.00% | Add |
| Yu Fan |
| 5.25% | 8.58% | #2 | $5.7M | 1.5M | $8.3M | 1.5M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 0.35% | 0.46% | #17 | $5.5M | 1.5M | $8.0M | 1.5M | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 0.77% | — | #12 | $5.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Propel Bio Management, LLC |
| 2.53% | 2.52% | #5 | $4.8M | 1.3M | $4.0M | 724,678 | +556,534+76.80% | Add |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.49% | — | #15 | $4.8M | 1.3M | $0 | 0 | +1.3M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #68 | $4.6M | 1.3M | $0 | 0 | +1.3M | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #41 | $4.2M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Ikarian Capital, LLC |
| 0.44% | 0.64% | #16 | $4.2M | 1.1M | $7.8M | 1.4M | -300,000-20.99% | Reduce |
| Polar Capital Holdings Plc |
| 0.01% | 0.04% | #37 | $4.1M | 1.1M | $11.8M | 2.1M | -1.1M-49.62% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #48 | $3.7M | 965,907 | $3.6M | 654,211 | +311,696+47.64% | Add |
| SYQUANT CAPITAL SAS |
| 0.78% | — | #11 | $3.5M | 913,135 | $0 | 0 | +913,135 | New Buy |
| Alyeska Investment Group, L.P. |
| 0.01% | — | #38 | $3.4M | 909,000 | $0 | 0 | +909,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #70 | $3.4M | 901,640 | $172,426 | 29,780 | +871,860+2,927.67% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $3.4M | 901,369 | $385,359 | 69,434 | +831,935+1,198.17% | Add |
| HighVista Strategies LLC |
| 0.72% | 0.94% | #13 | $3.1M | 831,442 | $3.4M | 615,666 | +215,776+35.05% | Add |
| Deep Track Capital, LP |
| 0.04% | 0.11% | #28 | $3.0M | 800,000 | $6.8M | 1.2M | -422,453-34.56% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #50 | $2.8M | 728,111 | $1.3M | 226,406 | +501,705+221.60% | Add |
| DIADEMA PARTNERS LP |
| 0.34% | 0.33% | #19 | $2.7M | 740,786 | $1.9M | 352,399 | +388,387+110.21% | Add |
| BVF INC/IL |
| 0.07% | 0.12% | #25 | $2.6M | 686,040 | $3.8M | 686,040 | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | — | #73 | $2.6M | 685,400 | $0 | 0 | +685,400 | New Buy |
| Ally Bridge Group (NY) LLC |
| 2.12% | 3.34% | #6 | $2.4M | 634,800 | $4.1M | 745,300 | -110,500-14.83% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | — | #53 | $1.5M | 397,558 | $0 | 0 | +397,558 | New Buy |
| J. Goldman & Co LP |
| 0.03% | 0.02% | #30 | $1.3M | 337,500 | $574,525 | 103,518 | +233,982+226.03% | Add |
| Simplify Asset Management Inc. |
| 0.02% | 0.02% | #34 | $1.2M | 313,483 | $1.3M | 227,923 | +85,560+37.54% | Add |
| Artisan Partners Limited Partnership |
| <0.01% | <0.01% | #52 | $996,174 | 263,538 | $1.8M | 323,006 | -59,468-18.41% | Reduce |
| Ghisallo Capital Management LLC |
| 0.01% | — | #42 | $945,000 | 250,000 | $0 | 0 | +250,000 | New Buy |
| Burkehill Global Management, LP |
| 0.03% | — | #31 | $850,500 | 225,000 | $0 | 0 | +225,000 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.03% | — | #29 | $850,500 | 225,000 | $0 | 0 | +225,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $848,606 | 224,499 | $1.0M | 184,907 | +39,592+21.41% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #36 | $809,986 | 214,282 | $366,972 | 66,121 | +148,161+224.08% | Add |
