| SR ONE CAPITAL MANAGEMENT, LP |
| 9.09% | 7.59% | #1 | $94.4M | 6.5M | $69.4M | 6.5M | 00.00% | Unchanged |
| Logos Global Management LP |
| 1.87% | 1.04% | #7 | $43.4M | 3.0M | $20.7M | 2.0M | +1.1M+53.85% | Add |
| BAKER BROS. ADVISORS LP |
| 0.19% | 0.16% | #16 | $38.8M | 2.7M | $27.5M | 2.6M | +92,452+3.58% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.22% | 0.14% | #14 | $38.5M | 2.7M | $18.6M | 1.7M | +916,128+52.50% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #68 | $38.5M | 2.7M | $22.7M | 2.1M | +526,260+24.66% | Add |
| Caption Management, LLC |
| 0.18% | 0.01% | #17 | $37.9M | 2.6M | $922,573 | 86,708 | +2.5M+2,919.44% | Add |
| Point72 Asset Management, L.P. |
| 0.04% | 0.04% | #26 | $34.2M | 2.4M | $29.0M | 2.7M | -356,301-13.09% | Reduce |
| Trails Edge Capital Partners, LP |
| 4.6% | 2.08% | #2 | $29.0M | 2.0M | $9.1M | 852,013 | +1.1M+134.89% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.57% | — | #10 | $26.2M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Vivo Capital, LLC |
| 2.13% | 1.43% | #5 | $23.3M | 1.6M | $17.2M | 1.6M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $22.7M | 1.6M | $14.4M | 1.3M | +221,172+16.38% | Add |
| Almitas Capital LLC |
| 3.46% | 3.68% | #3 | $14.9M | 1.0M | $16.3M | 1.5M | -503,442-32.90% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #62 | $13.9M | 958,417 | $7.4M | 692,518 | +265,899+38.40% | Add |
| Sofinnova Investments, Inc. |
| 0.65% | — | #9 | $12.5M | 865,135 | $0 | 0 | +865,135 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #73 | $11.2M | 776,462 | $8.5M | 798,411 | -21,949-2.75% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $11.1M | 765,425 | $1.3M | 175,991 | +589,434+334.92% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #84 | $10.7M | 736,221 | $7.0M | 659,575 | +76,646+11.62% | Add |
| Woodline Partners LP |
| 0.03% | 0.04% | #27 | $10.1M | 700,354 | $10.2M | 961,501 | -261,147-27.16% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #49 | $10.1M | 694,743 | $4.6M | 431,840 | +262,903+60.88% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $9.5M | 656,584 | $5.4M | 504,718 | +151,866+30.09% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.01% | #29 | $8.2M | 565,597 | $3.1M | 289,385 | +276,212+95.45% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #31 | $7.8M | 537,479 | $6.6M | 616,481 | -79,002-12.81% | Reduce |
| Siren, L.L.C. |
| 0.15% | — | #18 | $7.6M | 523,212 | $0 | 0 | +523,212 | New Buy |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #36 | $6.3M | 437,079 | $363,707 | 34,183 | +402,896+1,178.64% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #33 | $5.6M | 387,913 | $4.3M | 408,200 | -20,287-4.97% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.1% | 0.06% | #21 | $5.6M | 384,036 | $2.9M | 271,554 | +112,482+41.42% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #66 | $5.1M | 353,197 | $3.2M | 300,279 | +52,918+17.62% | Add |
| ALGERT GLOBAL LLC |
| 0.05% | 0.03% | #25 | $4.3M | 296,085 | $2.2M | 204,739 | +91,346+44.62% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.85% | 1.1% | #4 | $4.1M | 282,564 | $1.6M | 145,900 | +136,664+93.67% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #71 | $3.9M | 271,264 | $2.6M | 241,485 | +29,779+12.33% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $3.6M | 251,442 | $1.5M | 138,565 | +112,877+81.46% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #63 | $3.3M | 230,202 | $2.1M | 195,658 | +34,544+17.66% | Add |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #43 | $3.2M | 224,170 | $487,418 | 45,810 | +178,360+389.35% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #54 | $2.8M | 195,645 | $5.0M | 470,270 | -274,625-58.40% | Reduce |
| Eversept Partners, LP |
| 0.14% | — | #19 | $2.7M | 190,000 | $0 | 0 | +190,000 | New Buy |
| KVP Capital Advisors, LP |
| 1.96% | — | #6 | $2.7M | 185,000 | $0 | 0 | +185,000 | New Buy |
| J. Goldman & Co LP |
| 0.07% | — | #23 | $2.6M | 176,770 | $0 | 0 | +176,770 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $2.1M | 147,714 | $1.2M | 108,928 | +38,786+35.61% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #70 | $2.0M | 138,521 | $1.2M | 108,449 | +30,072+27.73% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #48 | $1.6M | 111,103 | $0 | 0 | +111,103 | New Buy |
| Elmind Capital, LP |
| 0.39% | 0.63% | #11 | $1.6M | 107,900 | $2.2M | 207,900 | -100,000-48.10% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #81 | $1.5M | 104,734 | $1.3M | 126,815 | -22,081-17.41% | Reduce |
| DAFNA Capital Management LLC |
| 0.28% | — | #12 | $1.5M | 102,600 | $0 | 0 | +102,600 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #95 | $1.4M | 95,871 | $2.5M | 231,513 | -135,642-58.59% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #90 | $1.3M | 92,069 | $847,424 | 79,645 | +12,424+15.60% | Add |
| China Universal Asset Management Co., Ltd. |
| 0.08% | 0.03% | #22 | $1.3M | 89,940 | $373,560 | 35,109 | +54,831+156.17% | Add |
| SummitTX Capital, L.P. |
| 0.03% | — | #28 | $1.2M | 80,663 | $0 | 0 | +80,663 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #72 | $1.1M | 76,825 | $698,388 | 65,638 | +11,187+17.04% | Add |
| Palumbo Wealth Management LLC |
| 0.22% | 0.19% | #15 | $1.0M | 71,744 | $759,782 | 71,408 | +336+0.47% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $1.0M | 71,114 | $276,184 | 25,957 | +45,157+173.97% | Add |
