| TCG Crossover Management, LLC |
| 0.87% | — | #6 | $36.0M | 11.1M | $0 | 0 | +11.1M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #86 | $34.3M | 10.6M | $22.9M | 9.3M | +1.3M+14.32% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.25% | — | #11 | $28.8M | 8.9M | $0 | 0 | +8.9M | New Buy |
| Commodore Capital LP |
| 1.72% | — | #2 | $28.8M | 8.9M | $0 | 0 | +8.9M | New Buy |
| ADAR1 Capital Management, LLC |
| 1.33% | — | #3 | $28.8M | 8.9M | $0 | 0 | +8.9M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $19.9M | 6.1M | $10.4M | 4.2M | +1.9M+46.07% | Add |
| Paradigm Biocapital Advisors LP |
| 0.34% | — | #9 | $18.1M | 5.6M | $0 | 0 | +5.6M | New Buy |
| Opaleye Management Inc. |
| 1.13% | 0.63% | #4 | $12.5M | 3.9M | $4.8M | 1.9M | +1.9M+100.41% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #85 | $11.7M | 3.6M | $7.8M | 3.1M | +449,769+14.28% | Add |
| Woodline Partners LP |
| 0.04% | — | #19 | $11.5M | 3.6M | $0 | 0 | +3.6M | New Buy |
| Vivo Capital, LLC |
| 1.05% | — | #5 | $11.5M | 3.6M | $0 | 0 | +3.6M | New Buy |
| GordonMD Global Investments LP |
| 4.01% | — | #1 | $10.1M | 3.1M | $0 | 0 | +3.1M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #78 | $8.5M | 2.6M | $1.4M | 558,577 | +2.1M+367.98% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #89 | $8.3M | 2.6M | $5.7M | 2.3M | +257,283+11.13% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.02% | #27 | $8.0M | 2.5M | $9.8M | 4.0M | -1.5M-37.84% | Reduce |
| Logos Global Management LP |
| 0.31% | — | #10 | $7.2M | 2.2M | $0 | 0 | +2.2M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #114 | $7.1M | 2.2M | $5.1M | 2.1M | +115,681+5.57% | Add |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #37 | $6.6M | 2.0M | $519,461 | 210,308 | +1.8M+868.72% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $6.2M | 1.9M | $4.8M | 1.9M | -42,891-2.21% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #101 | $6.0M | 1.9M | $4.3M | 1.9M | -84,890-4.36% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $5.1M | 1.6M | $3.4M | 1.4M | +201,745+14.72% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #44 | $4.3M | 1.3M | $3.8M | 1.5M | -216,087-13.95% | Reduce |
| Seven Fleet Capital Management LP |
| 0.71% | — | #7 | $4.3M | 1.3M | $0 | 0 | +1.3M | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #63 | $4.3M | 1.3M | $3.2M | 1.3M | +25,099+1.94% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #39 | $3.4M | 1.0M | $3.6M | 1.5M | -418,714-28.72% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.06% | 0.06% | #18 | $3.3M | 1.0M | $2.6M | 1.1M | -20,324-1.93% | Reduce |
| MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $2.8M | 878,042 | $1.8M | 730,054 | +147,988+20.27% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $2.8M | 868,032 | $2.1M | 861,326 | +6,706+0.78% | Add |
| Nantahala Capital Management, LLC |
| 0.09% | — | #14 | $2.8M | 852,700 | $0 | 0 | +852,700 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #104 | $2.7M | 819,693 | $1.8M | 742,443 | +77,250+10.40% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #103 | $2.4M | 750,763 | $972,572 | 393,754 | +357,009+90.67% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $2.4M | 742,950 | $1.5M | 614,036 | +128,914+20.99% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #118 | $2.4M | 734,845 | $890,941 | 360,705 | +374,140+103.72% | Add |
| PEAK6 LLC |
| <0.01% | <0.01% | #40 | $1.8M | 568,941 | $147,706 | 59,800 | +509,141+851.41% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #94 | $1.7M | 521,213 | $4.9M | 2.0M | -1.5M-73.64% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #83 | $1.6M | 498,997 | $0 | 0 | +498,997 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #22 | $1.5M | 477,099 | $822,345 | 332,933 | +144,166+43.30% | Add |
| Eversept Partners, LP |
| 0.08% | 0.04% | #15 | $1.5M | 458,809 | $718,570 | 290,919 | +167,890+57.71% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #120 | $1.5M | 455,661 | $2.2M | 875,789 | -420,128-47.97% | Reduce |
| Casdin Capital, LLC |
| 0.07% | — | #17 | $1.4M | 445,000 | $0 | 0 | +445,000 | New Buy |
| DIADEMA PARTNERS LP |
| 0.16% | — | #12 | $1.3M | 400,000 | $0 | 0 | +400,000 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.08% | 0.07% | #16 | $1.2M | 367,147 | $1.1M | 434,413 | -67,266-15.48% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #159 | $1.1M | 342,165 | $3.8M | 1.1M | -745,742-68.55% | Reduce |
| BIT Capital GmbH |
| 0.03% | — | #21 | $1.1M | 326,000 | $0 | 0 | +326,000 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #119 | $1.0M | 309,395 | $0 | 0 | +309,395 | New Buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $878,642 | 271,186 | $346,857 | 140,428 | +130,758+93.11% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #131 | $850,907 | 262,625 | $673,241 | 272,567 | -9,942-3.65% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #167 | $751,119 | 231,827 | $333,119 | 134,866 | +96,961+71.89% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #121 | $748,813 | 231,115 | $172,413 | 69,803 | +161,312+231.10% | Add |
| Erste Asset Management GmbH |
| 0.01% | — | #36 | $736,000 | 230,000 | $0 | 0 | +230,000 | New Buy |
