| FMR LLC |
| <0.01% | <0.01% | #45 | $56.5M | 8.2M | $72.9M | 8.1M | +61,334+0.76% | Add |
| ORBIMED ADVISORS LLC |
| 0.74% | 1.02% | #4 | $39.4M | 5.7M | $51.2M | 5.7M | 00.00% | Unchanged |
| NORGES BANK |
| <0.01% | <0.01% | #44 | $26.1M | 3.8M | $5.9M | 969,916 | +2.8M+288.55% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $26.0M | 3.8M | $30.3M | 3.4M | +382,669+11.35% | Add |
| Decheng Capital LLC |
| 2.58% | 3.71% | #2 | $18.9M | 2.7M | $24.5M | 2.7M | 00.00% | Unchanged |
| Enavate Sciences GP, LLC |
| 4.93% | 6.3% | #1 | $17.0M | 2.5M | $22.1M | 2.5M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $13.0M | 1.9M | $16.9M | 1.9M | +3,160+0.17% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $7.9M | 1.1M | $8.4M | 937,323 | +206,452+22.03% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #41 | $7.2M | 1.0M | $7.4M | 820,480 | +215,564+26.27% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #73 | $7.0M | 1.0M | $4.1M | 463,001 | +549,043+118.58% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #33 | $6.8M | 978,500 | $5.6M | 619,321 | +359,179+58.00% | Add |
| Parkman Healthcare Partners LLC |
| 0.66% | 0.73% | #5 | $6.5M | 935,247 | $7.1M | 786,783 | +148,464+18.87% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $6.4M | 931,261 | $8.6M | 950,617 | -19,356-2.04% | Reduce |
| SEB Asset Management AB |
| 0.02% | 0.03% | #19 | $6.1M | 878,473 | $7.9M | 878,473 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.02% | 0.03% | #23 | $5.8M | 831,481 | $7.5M | 831,481 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #95 | $5.3M | 766,323 | $6.3M | 705,350 | +60,973+8.64% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $4.9M | 712,667 | $6.5M | 727,711 | -15,044-2.07% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.09% | 0.17% | #12 | $4.8M | 693,555 | $9.0M | 1.0M | -307,076-30.69% | Reduce |
| Bain Capital Life Sciences Investors, LLC |
| 0.25% | 0.7% | #7 | $4.2M | 600,949 | $7.8M | 867,211 | -266,262-30.70% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $3.8M | 544,869 | $649,539 | 72,171 | +472,698+654.97% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $3.6M | 524,632 | $1.6M | 87,535 | +437,097+499.34% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #51 | $3.5M | 511,546 | $1.1M | 126,000 | +385,546+305.99% | Add |
| Walleye Capital LLC |
| 0.01% | — | #26 | $3.4M | 498,490 | $0 | 0 | +498,490 | New Buy |
| Trexquant Investment LP |
| 0.02% | 0.01% | #22 | $3.2M | 466,430 | $1.6M | 176,657 | +289,773+164.03% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #40 | $3.1M | 453,011 | $1.7M | 189,668 | +263,343+138.84% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #94 | $2.7M | 391,762 | $436,140 | 48,460 | +343,302+708.42% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #67 | $2.6M | 381,613 | $719,492 | 80,002 | +301,611+377.00% | Add |
| Altshuler Shaham Ltd |
| 0.03% | 0.06% | #18 | $2.6M | 380,061 | $3.4M | 380,061 | 00.00% | Unchanged |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #56 | $2.5M | 357,756 | $1.7M | 185,087 | +172,669+93.29% | Add |
| Samsara BioCapital, LLC |
| 0.2% | 0.64% | #9 | $2.4M | 353,717 | $6.6M | 736,047 | -382,330-51.94% | Reduce |
| Propel Bio Management, LLC |
| 1.27% | 1.95% | #3 | $2.4M | 350,389 | $3.1M | 341,779 | +8,610+2.52% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #72 | $2.4M | 342,353 | $3.1M | 342,353 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #83 | $2.1M | 297,346 | $2.3M | 260,992 | +36,354+13.93% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #46 | $2.0M | 290,904 | $401,634 | 44,626 | +246,278+551.87% | Add |
| Voleon Capital Management LP |
| 0.04% | — | #15 | $2.0M | 285,234 | $0 | 0 | +285,234 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $1.8M | 262,456 | $2.3M | 257,729 | +4,727+1.83% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #32 | $1.8M | 253,092 | $0 | 0 | +253,092 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #97 | $1.7M | 246,917 | $2.8M | 316,587 | -69,670-22.01% | Reduce |
| XTX Topco Ltd |
| 0.02% | 0.03% | #20 | $1.7M | 242,346 | $1.9M | 209,277 | +33,069+15.80% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #66 | $1.7M | 241,447 | $1.6M | 180,889 | +60,558+33.48% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $1.7M | 239,616 | $2.0M | 224,157 | +15,459+6.90% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #90 | $1.6M | 234,714 | $2.1M | 231,254 | +3,460+1.50% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.01% | 0.01% | #35 | $1.6M | 225,760 | $1.5M | 161,349 | +64,411+39.92% | Add |
| Jump Financial, LLC |
| 0.01% | 0.04% | #25 | $1.5M | 223,223 | $2.9M | 319,400 | -96,177-30.11% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.2% | 0.51% | #10 | $1.5M | 219,700 | $3.2M | 358,000 | -138,300-38.63% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #52 | $1.2M | 175,110 | $0 | 0 | +175,110 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #47 | $1.2M | 170,590 | $0 | 0 | +170,590 | New Buy |
| Boxer Capital Management, LLC |
| 0.08% | 0.18% | #14 | $1.0M | 150,000 | $1.4M | 150,000 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #54 | $908,596 | 131,300 | $558,900 | 62,100 | +69,200+111.43% | Add |
| EntryPoint Capital, LLC |
| 0.22% | 0.19% | #8 | $895,766 | 129,446 | $662,112 | 73,568 | +55,878+75.95% | Add |
