| MONTANOVA CAPITAL, LLC |
| 2.87% | 2.59% | #9 | $156.9M | 4.5M | $101.5M | 4.4M | +114,448+2.60% | Add |
| INFINITUM ASSET MANAGEMENT, LLC |
| 15.68% | 11.95% | #3 | $154.2M | 4.4M | $95.7M | 4.1M | +289,461+6.98% | Add |
| Hillhouse Capital Advisors, Ltd. |
| 16.4% | 5.42% | #2 | $136.5M | 3.9M | $90.6M | 3.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #73 | $112.9M | 3.3M | $58.4M | 2.5M | +720,095+28.46% | Add |
| ORBIMED ADVISORS LLC |
| 1.98% | 1.38% | #11 | $105.2M | 3.0M | $69.8M | 3.0M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #55 | $96.5M | 2.8M | $69.6M | 3.0M | -237,173-7.86% | Reduce |
| Octagon Capital Advisors LP |
| 6.15% | 5.03% | #4 | $68.5M | 2.0M | $45.5M | 2.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $61.7M | 1.8M | $35.3M | 1.5M | +245,980+16.09% | Add |
| Sofinnova Investments, Inc. |
| 3.05% | 1.49% | #7 | $58.9M | 1.7M | $39.1M | 1.7M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #72 | $58.8M | 1.7M | $32.8M | 1.4M | +271,571+19.11% | Add |
| Vivo Capital, LLC |
| 5.34% | 1.7% | #5 | $58.4M | 1.7M | $20.4M | 885,916 | +796,181+89.87% | Add |
| Novo Holdings A/S |
| 3.04% | 3.63% | #8 | $52.1M | 1.5M | $44.8M | 1.9M | -442,142-22.77% | Reduce |
| General Catalyst Group Management, LLC |
| 27.55% | 18.79% | #1 | $51.9M | 1.5M | $34.5M | 1.5M | 00.00% | Unchanged |
| Logos Global Management LP |
| 1.5% | 0.4% | #16 | $34.7M | 1.0M | $8.1M | 350,000 | +650,000+185.71% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #71 | $33.8M | 972,626 | $18.5M | 803,652 | +168,974+21.03% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #42 | $30.3M | 872,011 | $8.5M | 368,795 | +503,216+136.45% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #64 | $29.7M | 853,723 | $19.7M | 853,427 | +296+0.03% | Add |
| HSG Holding Ltd |
| 1.92% | 0.86% | #13 | $23.0M | 663,308 | $14.0M | 663,308 | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #36 | $19.7M | 566,796 | $17.3M | 748,195 | -181,399-24.24% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #76 | $19.6M | 564,982 | $4.4M | 190,698 | +374,284+196.27% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #54 | $15.2M | 438,664 | $9.8M | 425,923 | +12,741+2.99% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #67 | $15.2M | 438,594 | $11.2M | 486,263 | -47,669-9.80% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #37 | $13.7M | 395,447 | $9.8M | 426,281 | -30,834-7.23% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #62 | $13.3M | 381,589 | $4.2M | 180,028 | +201,561+111.96% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #106 | $11.6M | 335,320 | $5.9M | 253,852 | +81,468+32.09% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $11.6M | 332,753 | $6.2M | 268,812 | +63,941+23.79% | Add |
| Foresite Capital Management VI LLC |
| 1.63% | — | #15 | $10.5M | 301,341 | $0 | 0 | +301,341 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #79 | $10.2M | 294,224 | $6.0M | 258,772 | +35,452+13.70% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #66 | $9.0M | 259,290 | $5.0M | 217,127 | +42,163+19.42% | Add |
| Seven Fleet Capital Management LP |
| 1.41% | 0.37% | #17 | $8.6M | 246,606 | $1.2M | 50,252 | +196,354+390.74% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #88 | $8.3M | 238,342 | $8.1M | 353,257 | -114,915-32.53% | Reduce |
| ACUTA CAPITAL PARTNERS, LLC |
| 5.29% | — | #6 | $7.6M | 218,694 | $0 | 0 | +218,694 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #81 | $7.3M | 211,509 | $2.9M | 126,525 | +84,984+67.17% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #115 | $6.6M | 189,910 | $7.2M | 392,022 | -202,112-51.56% | Reduce |
| Squadron Capital Management LLC |
| 1.97% | 0.93% | #12 | $6.4M | 183,000 | $2.5M | 110,000 | +73,000+66.36% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #112 | $6.1M | 174,866 | $1.9M | 80,208 | +94,658+118.02% | Add |
| NOMURA HOLDINGS INC |
| 0.01% | 0.01% | #51 | $5.4M | 154,617 | $5.6M | 242,050 | -87,433-36.12% | Reduce |
| Woodline Partners LP |
| 0.02% | 0.01% | #38 | $5.1M | 147,639 | $3.4M | 147,639 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #110 | $5.1M | 145,400 | $2.8M | 122,858 | +22,542+18.35% | Add |
| Affinity Asset Advisors, LLC |
| 0.2% | 0.21% | #20 | $4.3M | 125,000 | $4.0M | 175,000 | -50,000-28.57% | Reduce |
| HRT FINANCIAL LP |
| 0.01% | <0.01% | #50 | $4.2M | 121,224 | $1.1M | 47,053 | +74,171+157.63% | Add |
| E Fund Management Co., Ltd. |
| 0.09% | 0.06% | #29 | $3.8M | 109,328 | $2.2M | 93,953 | +15,375+16.36% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #91 | $3.7M | 107,851 | $1.3M | 56,839 | +51,012+89.75% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #99 | $3.6M | 103,931 | $1.7M | 75,448 | +28,483+37.75% | Add |
| KVP Capital Advisors, LP |
| 2.6% | — | #10 | $3.5M | 102,000 | $0 | 0 | +102,000 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #98 | $3.5M | 100,855 | $1.8M | 78,213 | +22,642+28.95% | Add |
| Burkehill Global Management, LP |
| 0.13% | 0.11% | #26 | $3.5M | 100,000 | $2.3M | 100,000 | 00.00% | Unchanged |
| SECTORAL ASSET MANAGEMENT INC |
| 1.92% | 0.6% | #14 | $2.7M | 79,043 | $720,430 | 30,013 | +49,030+163.36% | Add |
| Trexquant Investment LP |
| 0.01% | — | #40 | $2.5M | 71,860 | $0 | 0 | +71,860 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #108 | $2.5M | 70,970 | $1.5M | 65,408 | +5,562+8.50% | Add |
