| FMR LLC |
| 0.01% | 0.01% | #29 | $240.1M | 9.2M | $234.3M | 9.0M | +187,498+2.07% | Add |
| Fairmount Funds Management LLC |
| 14.98% | 16.3% | #1 | $226.6M | 8.7M | $225.7M | 8.7M | 00.00% | Unchanged |
| Avoro Capital Advisors LLC |
| 0.88% | 0.96% | #13 | $98.4M | 3.8M | $98.0M | 3.8M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 2.84% | 3.48% | #5 | $93.7M | 3.6M | $93.3M | 3.6M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $82.2M | 3.2M | $5.8M | 222,437 | +2.9M+1,321.56% | Add |
| FCPM III SERVICES B.V. |
| 8.46% | 8.75% | #3 | $63.5M | 2.4M | $63.2M | 2.4M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.54% | 0.66% | #15 | $62.4M | 2.4M | $62.1M | 2.4M | +392+0.02% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.17% | 0.17% | #23 | $60.1M | 2.3M | $59.9M | 2.3M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.02% | — | #28 | $59.3M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Remedium Capital Partners, LLC |
| 11.78% | 18.84% | #2 | $53.2M | 2.0M | $53.0M | 2.0M | 00.00% | Unchanged |
| Commodore Capital LP |
| 3% | 2.91% | #4 | $50.4M | 1.9M | $50.2M | 1.9M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | — | #39 | $49.8M | 2.1M | $0 | 0 | +2.1M | New Buy |
| BRAIDWELL LP |
| 1.56% | 0.77% | #8 | $42.1M | 1.6M | $23.2M | 894,846 | +725,531+81.08% | Add |
| Bellevue Group AG |
| 0.89% | 1.42% | #12 | $42.1M | 1.6M | $59.5M | 2.3M | -679,154-29.55% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #49 | $40.2M | 1.5M | $4.8M | 183,922 | +1.4M+740.30% | Add |
| a16z Capital Management, L.L.C. |
| 2.55% | 2.48% | #7 | $32.0M | 1.2M | $32.0M | 1.2M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.05% | #27 | $32.0M | 1.2M | $37.5M | 1.4M | -218,873-15.12% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.48% | 0.62% | #18 | $31.8M | 1.2M | $31.7M | 1.2M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.01% | #34 | $27.5M | 1.1M | $27.4M | 1.1M | 00.00% | Unchanged |
| Blackstone Inc. |
| 0.08% | 0.05% | #25 | $26.1M | 1.0M | $13.0M | 503,522 | +499,449+99.19% | Add |
| Cormorant Asset Management, LP |
| 1.32% | 1.98% | #9 | $26.0M | 1.0M | $39.5M | 1.5M | -525,000-34.43% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $25.1M | 965,364 | $6.2M | 241,126 | +724,238+300.36% | Add |
| Siren, L.L.C. |
| 0.47% | 0.65% | #19 | $23.4M | 900,000 | $23.3M | 900,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #38 | $21.9M | 840,292 | $4.2M | 160,415 | +679,877+423.82% | Add |
| Vestal Point Capital, LP |
| 0.35% | 0.43% | #20 | $15.0M | 575,000 | $15.5M | 600,000 | -25,000-4.17% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.5% | 0.6% | #16 | $11.1M | 425,000 | $11.7M | 450,000 | -25,000-5.56% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #69 | $9.5M | 365,499 | $0 | 0 | +365,499 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #51 | $9.4M | 359,705 | $1.0M | 38,882 | +320,823+825.12% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $8.8M | 339,379 | $2.3M | 88,336 | +251,043+284.19% | Add |
| Ikarian Capital, LLC |
| 0.93% | 0.71% | #11 | $8.7M | 335,710 | $8.7M | 335,710 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #43 | $8.5M | 324,929 | $3.0M | 117,675 | +207,254+176.12% | Add |
| Seven Fleet Capital Management LP |
| 1.22% | 0.83% | #10 | $7.4M | 284,430 | $2.6M | 101,248 | +183,182+180.92% | Add |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.43% | #21 | $7.3M | 280,000 | $7.2M | 279,000 | +1,000+0.36% | Add |
| Nantahala Capital Management, LLC |
| 0.24% | 0.27% | #22 | $7.2M | 278,000 | $7.2M | 278,000 | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 0.8% | — | #14 | $5.6M | 216,194 | $0 | 0 | +216,194 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $5.5M | 212,600 | $5.2M | 201,847 | +10,753+5.33% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | — | #65 | $4.3M | 166,347 | $0 | 0 | +166,347 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #62 | $3.9M | 151,016 | $0 | 0 | +151,016 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #55 | $3.9M | 149,592 | $0 | 0 | +149,592 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #66 | $3.7M | 142,137 | $323,750 | 12,500 | +129,637+1,037.10% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #60 | $3.7M | 141,833 | $2.5M | 96,664 | +45,169+46.73% | Add |
| Kalehua Capital Management LLC |
| 2.59% | 2.55% | #6 | $3.6M | 139,000 | $3.6M | 139,000 | 00.00% | Unchanged |
| DV EQUITIES, LLC |
| 0.48% | — | #17 | $3.4M | 130,000 | $0 | 0 | +130,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #85 | $3.1M | 119,027 | $0 | 0 | +119,027 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $2.6M | 98,284 | $405,257 | 15,647 | +82,637+528.13% | Add |
| Swiss National Bank |
| <0.01% | — | #53 | $1.9M | 72,600 | $0 | 0 | +72,600 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #47 | $1.7M | 65,833 | $0 | 0 | +65,833 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #67 | $1.4M | 55,710 | $0 | 0 | +55,710 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #71 | $1.4M | 52,774 | $0 | 0 | +52,774 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | 0.04% | #44 | $1.3M | 48,754 | $30.9M | 1.2M | -1.1M-95.92% | Reduce |
