| BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $35.1M | 9.2M | $32.8M | 6.2M | +3.0M+48.39% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.33% | 0.43% | #10 | $26.8M | 7.0M | $24.3M | 4.6M | +2.4M+52.96% | Add |
| RTW INVESTMENTS, LP |
| 0.22% | 0.35% | #16 | $25.3M | 6.6M | $34.9M | 6.6M | +59,487+0.90% | Add |
| Deep Track Capital, LP |
| 0.32% | 0.5% | #11 | $21.9M | 5.7M | $30.4M | 5.7M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $19.6M | 5.1M | $18.6M | 3.5M | +1.6M+45.99% | Add |
| Rosalind Advisors, Inc. |
| 3.61% | 4.55% | #1 | $15.2M | 4.0M | $11.3M | 2.1M | +1.8M+86.42% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $14.7M | 3.9M | $17.6M | 3.3M | +528,738+15.91% | Add |
| Nantahala Capital Management, LLC |
| 0.46% | 0.7% | #9 | $13.7M | 3.6M | $19.0M | 3.6M | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 1.96% | 7.01% | #3 | $12.8M | 3.3M | $17.5M | 3.3M | +47,327+1.43% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $12.5M | 3.3M | $4.0M | 756,875 | +2.5M+331.63% | Add |
| Foresite Capital Management VI LLC |
| 1.87% | 3.62% | #4 | $12.0M | 3.1M | $16.7M | 3.1M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $10.4M | 2.7M | $7.9M | 1.5M | +1.2M+83.37% | Add |
| BAKER BROS. ADVISORS LP |
| 0.05% | 0.02% | #23 | $9.5M | 2.5M | $3.1M | 584,757 | +1.9M+327.41% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.03% | #27 | $8.7M | 2.3M | $10.9M | 2.1M | +239,625+11.69% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #44 | $8.3M | 2.2M | $12.8M | 2.4M | -248,562-10.31% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $7.9M | 2.1M | $9.1M | 1.7M | +356,588+20.76% | Add |
| AIGH Capital Management LLC |
| 0.46% | 1.45% | #8 | $7.4M | 1.9M | $10.6M | 2.0M | -73,000-3.65% | Reduce |
| Opaleye Management Inc. |
| 0.62% | — | #7 | $6.9M | 1.8M | $0 | 0 | +1.8M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #34 | $6.4M | 1.7M | $2.2M | 409,779 | +1.3M+311.58% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #37 | $6.2M | 1.6M | $7.8M | 1.5M | +152,460+10.33% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 1.53% | 2.21% | #5 | $5.6M | 1.5M | $7.8M | 1.5M | 00.00% | Unchanged |
| NEXTBio Capital Management LP |
| 2.3% | 3.22% | #2 | $5.0M | 1.3M | $6.9M | 1.3M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #60 | $4.2M | 1.1M | $5.9M | 1.1M | -864-0.08% | Reduce |
| Pinnacle Financial Partners, Inc. |
| 0.03% | 0.02% | #24 | $4.2M | 1.1M | $2.6M | 495,266 | +591,174+119.36% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $3.6M | 934,565 | $350,143 | 66,065 | +868,500+1,314.61% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #86 | $3.4M | 889,975 | $2.2M | 416,985 | +472,990+113.43% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #100 | $2.7M | 715,822 | $13.9M | 1.6M | -863,664-54.68% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #92 | $2.6M | 681,929 | $2.0M | 384,960 | +296,969+77.14% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #35 | $2.5M | 666,874 | $1.3M | 244,103 | +422,771+173.19% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $2.5M | 651,495 | $2.7M | 515,786 | +135,709+26.31% | Add |
| J. Goldman & Co LP |
| 0.06% | 0.26% | #21 | $2.5M | 650,074 | $8.9M | 1.7M | -1.0M-61.32% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.32% | 0.29% | #13 | $2.4M | 632,632 | $1.8M | 343,678 | +288,954+84.08% | Add |
| FMR LLC |
| <0.01% | <0.01% | #108 | $2.4M | 626,298 | $2.5M | 473,657 | +152,641+32.23% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #73 | $2.4M | 616,862 | $2.6M | 494,694 | +122,168+24.70% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #79 | $2.3M | 604,480 | $2.9M | 543,689 | +60,791+11.18% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.06% | 0.04% | #22 | $2.2M | 569,195 | $1.2M | 221,323 | +347,872+157.18% | Add |
| XTX Topco Ltd |
| 0.03% | 0.04% | #25 | $2.1M | 561,791 | $2.1M | 395,834 | +165,957+41.93% | Add |
| Jefferies Financial Group Inc. |
| 0.01% | 0.02% | #29 | $1.9M | 496,529 | $2.9M | 556,016 | -59,487-10.70% | Reduce |
| TORRAY INVESTMENT PARTNERS LLC |
| 0.25% | 0.23% | #15 | $1.8M | 477,455 | $1.6M | 298,958 | +178,497+59.71% | Add |
| TORONTO DOMINION BANK |
| <0.01% | <0.01% | #49 | $1.8M | 460,413 | $2.4M | 460,413 | 00.00% | Unchanged |
| Exome Asset Management LLC |
| 1.01% | 1.75% | #6 | $1.6M | 429,041 | $3.4M | 636,700 | -207,659-32.61% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #93 | $1.6M | 411,927 | $12.6M | 2.4M | -2.0M-82.66% | Reduce |
| Palo Alto Investors LP |
| 0.17% | 0.2% | #17 | $1.2M | 309,685 | $1.3M | 246,093 | +63,592+25.84% | Add |
| Jump Financial, LLC |
| 0.01% | 0.01% | #32 | $1.2M | 307,500 | $627,906 | 118,473 | +189,027+159.55% | Add |
| Virtus Investment Advisers, LLC |
| 0.25% | 0.04% | #14 | $1.1M | 283,630 | $150,382 | 28,374 | +255,256+899.61% | Add |
| Diametric Capital, LP |
| 0.11% | — | #18 | $1.0M | 265,539 | $0 | 0 | +265,539 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #84 | $989,124 | 258,933 | $1.1M | 206,096 | +52,837+25.64% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #102 | $931,889 | 243,950 | $1.0M | 196,501 | +47,449+24.15% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #97 | $898,490 | 235,207 | $0 | 0 | +235,207 | New Buy |
| Ikarian Capital, LLC |
| 0.09% | 0.09% | #20 | $816,965 | 213,865 | $1.1M | 213,865 | 00.00% | Unchanged |
