| MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $41.4M | 8.9M | $11.0M | 5.0M | +3.9M+78.34% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.32% | 0.22% | #12 | $37.4M | 8.0M | $21.0M | 8.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #91 | $36.9M | 7.9M | $5.4M | 2.0M | +5.8M+285.48% | Add |
| Squadron Capital Management LLC |
| 11.01% | 2.17% | #1 | $35.5M | 7.6M | $5.9M | 2.3M | +5.4M+237.78% | Add |
| Lynx1 Capital Management LP |
| 6.74% | 2.91% | #2 | $34.2M | 7.3M | $18.4M | 7.0M | +327,789+4.68% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 1.99% | 1.7% | #3 | $33.5M | 7.2M | $18.9M | 7.2M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #74 | $20.7M | 4.7M | $7.6M | 3.2M | +1.5M+47.30% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $20.6M | 4.4M | $10.2M | 3.9M | +555,879+14.39% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $20.0M | 4.3M | $6.8M | 2.6M | +1.7M+65.50% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #71 | $16.5M | 3.5M | $6.3M | 2.4M | +1.1M+47.90% | Add |
| WASATCH ADVISORS LP |
| 0.11% | 0.05% | #17 | $16.5M | 3.5M | $7.8M | 3.0M | +560,883+18.94% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #33 | $16.2M | 3.5M | $8.0M | 3.0M | +434,073+14.30% | Add |
| Soleus Capital Management, L.P. |
| 0.54% | 0.41% | #9 | $15.8M | 3.4M | $10.0M | 3.8M | -425,961-11.20% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.47% | 0.51% | #5 | $14.2M | 3.0M | $5.0M | 1.9M | +1.1M+58.60% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $12.4M | 2.7M | $6.2M | 2.4M | +297,118+12.59% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #87 | $11.8M | 2.5M | $2.5M | 951,043 | +1.6M+165.20% | Add |
| Ikarian Capital, LLC |
| 1.21% | — | #7 | $11.4M | 2.4M | $0 | 0 | +2.4M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #105 | $9.9M | 2.1M | $1.0M | 382,973 | +1.7M+452.42% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $9.5M | 2.0M | $3.7M | 1.4M | +635,370+45.56% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $8.4M | 1.8M | $5.0M | 1.9M | -84,715-4.48% | Reduce |
| Candriam S.C.A. |
| 0.04% | — | #25 | $8.4M | 1.8M | $0 | 0 | +1.8M | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #50 | $8.1M | 1.7M | $2.8M | 1.1M | +680,658+64.19% | Add |
| Patient Square Capital LP |
| 1.16% | — | #8 | $7.5M | 1.6M | $0 | 0 | +1.6M | New Buy |
| HighVista Strategies LLC |
| 1.44% | — | #6 | $6.3M | 1.3M | $0 | 0 | +1.3M | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #38 | $5.6M | 1.2M | $6.5M | 2.5M | -1.3M-51.67% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $5.5M | 1.2M | $1.2M | 442,518 | +745,989+168.58% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #86 | $5.4M | 1.2M | $498,330 | 189,479 | +971,068+512.49% | Add |
| CONGRESS ASSET MANAGEMENT CO |
| 0.03% | 0.02% | #28 | $4.7M | 1.0M | $2.2M | 830,624 | +172,813+20.81% | Add |
| FMR LLC |
| <0.01% | <0.01% | #111 | $4.2M | 894,054 | $716,327 | 272,368 | +621,686+228.25% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #93 | $3.9M | 828,970 | $567,756 | 215,877 | +613,093+284.00% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #94 | $3.6M | 781,060 | $1.2M | 452,228 | +328,832+72.71% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.05% | — | #24 | $3.4M | 736,331 | $0 | 0 | +736,331 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #117 | $3.2M | 680,094 | $0 | 0 | +680,094 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #88 | $2.8M | 609,146 | $1.3M | 484,131 | +125,015+25.82% | Add |
| ExodusPoint Capital Management, LP |
| 0.02% | — | #30 | $2.7M | 580,195 | $0 | 0 | +580,195 | New Buy |
| Velan Capital Investment Management LP |
| 1.62% | — | #4 | $2.7M | 570,000 | $0 | 0 | +570,000 | New Buy |
| STEMPOINT CAPITAL LP |
| 0.35% | 0.22% | #11 | $2.4M | 523,648 | $1.2M | 453,236 | +70,412+15.54% | Add |
| Rockefeller Capital Management L.P. |
| <0.01% | — | #53 | $2.3M | 495,817 | $0 | 0 | +495,817 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #92 | $2.3M | 484,010 | $0 | 0 | +484,010 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #102 | $2.1M | 452,701 | $2.3M | 867,911 | -415,210-47.84% | Reduce |
| Man Group plc |
| <0.01% | <0.01% | #54 | $1.9M | 408,648 | $674,511 | 256,468 | +152,180+59.34% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.44% | 0.26% | #10 | $1.8M | 384,766 | $1.0M | 384,766 | 00.00% | Unchanged |
| Seven Fleet Capital Management LP |
| 0.29% | 0.05% | #13 | $1.8M | 381,169 | $150,110 | 57,076 | +324,093+567.83% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #68 | $1.7M | 370,554 | $2.0M | 752,114 | -381,560-50.73% | Reduce |
| Atom Investors LP |
| 0.15% | 0.03% | #15 | $1.7M | 364,351 | $357,804 | 136,047 | +228,304+167.81% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #120 | $1.6M | 353,050 | $3.5M | 1.3M | -993,746-73.79% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #29 | $1.6M | 335,079 | $684,534 | 260,279 | +74,800+28.74% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #61 | $1.5M | 325,000 | $0 | 0 | +325,000 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #56 | $1.4M | 300,734 | $728,991 | 277,183 | +23,551+8.50% | Add |
| ADAR1 Capital Management, LLC |
| 0.06% | 0.01% | #22 | $1.4M | 291,957 | $113,090 | 43,000 | +248,957+578.97% | Add |
