| BAKER BROS. ADVISORS LP |
| 17.48% | 16.62% | #1 | $3.49B | 30.8M | $2.89B | 30.7M | +17,918+0.06% | Add |
| BlackRock, Inc. |
| 0.03% | 0.03% | #332 | $2.04B | 18.0M | $1.79B | 19.0M | -945,480-4.98% | Reduce |
| DODGE & COX |
| 0.71% | 0.63% | #38 | $1.36B | 12.0M | $1.15B | 12.3M | -295,030-2.41% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.03% | 0.03% | #368 | $1.25B | 11.0M | $1.03B | 10.9M | +94,223+0.86% | Add |
| STATE STREET CORP |
| 0.03% | 0.03% | #316 | $1.10B | 9.7M | $907.4M | 9.6M | +80,952+0.84% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.04% | 0.04% | #292 | $883.2M | 7.8M | $730.3M | 7.8M | +31,908+0.41% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.21% | 0.25% | #102 | $603.2M | 5.3M | $536.1M | 5.8M | -487,029-8.39% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.03% | #347 | $536.5M | 4.8M | $441.1M | 4.7M | +47,551+1.01% | Add |
| LSV ASSET MANAGEMENT |
| 0.85% | 0.8% | #27 | $467.5M | 4.1M | $369.0M | 3.9M | +203,703+5.20% | Add |
| Invesco Ltd. |
| 0.04% | 0.05% | #304 | $462.6M | 4.1M | $364.3M | 3.9M | +209,697+5.42% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.06% | #224 | $405.3M | 3.6M | $307.4M | 3.3M | +309,385+9.47% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.55% | 0.54% | #51 | $398.1M | 3.5M | $343.7M | 3.7M | -139,400-3.82% | Reduce |
| MORGAN STANLEY |
| 0.02% | 0.01% | #451 | $334.2M | 2.9M | $224.0M | 2.6M | +307,628+11.65% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.14% | 0.14% | #143 | $311.2M | 2.7M | $266.4M | 2.8M | -85,841-3.03% | Reduce |
| Robeco Institutional Asset Management B.V. |
| 0.34% | 0.34% | #72 | $276.8M | 2.4M | $236.7M | 2.5M | -72,648-2.89% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.02% | 0.03% | #405 | $261.4M | 2.3M | $221.3M | 2.4M | -45,439-1.93% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.05% | 0.04% | #272 | $258.6M | 2.3M | $185.9M | 2.0M | +305,259+15.45% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.16% | 0.03% | #125 | $227.1M | 2.0M | $39.1M | 415,914 | +1.6M+381.72% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.02% | #399 | $199.7M | 1.8M | $174.1M | 1.8M | -87,760-4.74% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.03% | 0.02% | #378 | $191.9M | 1.7M | $162.7M | 1.7M | -36,663-2.12% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.22% | 0.25% | #96 | $188.7M | 1.7M | $178.9M | 1.9M | -235,825-12.41% | Reduce |
| Legal & General Group Plc |
| 0.04% | 0.03% | #298 | $182.1M | 1.6M | $145.2M | 1.5M | +62,792+4.07% | Add |
| FIRST TRUST ADVISORS LP |
| 0.11% | 0.1% | #173 | $180.0M | 1.6M | $141.3M | 1.5M | +87,204+5.81% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.03% | 0.03% | #324 | $171.0M | 1.5M | $145.0M | 1.5M | -32,193-2.09% | Reduce |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.09% | 0.11% | #185 | $167.8M | 1.5M | $164.0M | 1.7M | -262,528-15.06% | Reduce |
| Pacer Advisors, Inc. |
| 0.48% | 0.54% | #53 | $162.3M | 1.4M | $163.9M | 1.7M | -309,635-17.78% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #587 | $156.6M | 1.4M | $110.4M | 1.2M | +208,883+17.81% | Add |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
| 0.22% | 0.23% | #98 | $155.4M | 1.4M | $143.1M | 1.5M | -149,983-9.86% | Reduce |
| MARSHALL WACE, LLP |
| 0.12% | 0.12% | #158 | $148.5M | 1.3M | $117.9M | 1.3M | +57,016+4.55% | Add |
| HSBC HOLDINGS PLC |
| 0.06% | 0.03% | #238 | $148.3M | 1.3M | $54.8M | 582,368 | +725,375+124.56% | Add |
| DEUTSCHE BANK AG\ |
| 0.04% | 0.04% | #287 | $143.2M | 1.3M | $119.0M | 1.3M | -1,207-0.10% | Reduce |
| AustralianSuper Pty Ltd |
| 0.59% | 0.56% | #48 | $135.6M | 1.2M | $107.0M | 1.1M | +59,348+5.22% | Add |
| Amundi |
| 0.03% | 0.03% | #318 | $133.9M | 1.2M | $94.5M | 1.0M | +177,529+17.68% | Add |
| ROYAL BANK OF CANADA |
| 0.02% | 0.02% | #434 | $128.3M | 1.1M | $99.2M | 1.1M | +77,929+7.39% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #495 | $126.9M | 1.1M | $82.1M | 1.4M | -237,570-17.51% | Reduce |
| Bank of New York Mellon Corp |
| 0.02% | 0.02% | #446 | $110.3M | 972,825 | $93.2M | 989,709 | -16,884-1.71% | Reduce |
| Man Group plc |
| 0.17% | 0.16% | #122 | $108.0M | 952,941 | $87.5M | 930,171 | +22,770+2.45% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #396 | $107.0M | 943,540 | $89.3M | 948,295 | -4,755-0.50% | Reduce |
| BNP Paribas Asset Management Holding S.A. |
| 0.11% | — | #170 | $106.3M | 937,763 | $0 | 0 | +937,763 | New Buy |
| ARMISTICE CAPITAL, LLC |
| 1.25% | 1.1% | #21 | $102.0M | 900,005 | $61.8M | 656,817 | +243,188+37.03% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.31% | 0.43% | #84 | $100.0M | 881,889 | $114.0M | 1.2M | -329,020-27.17% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #619 | $87.3M | 761,690 | $44.9M | 497,042 | +264,648+53.24% | Add |
| UBS Group AG |
| 0.01% | 0.02% | #518 | $87.1M | 767,924 | $107.3M | 1.1M | -372,312-32.65% | Reduce |
| SOUND SHORE MANAGEMENT INC /CT/ |
| 2.64% | 2.42% | #7 | $85.9M | 757,723 | $72.3M | 767,829 | -10,106-1.32% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.3% | 0.68% | #85 | $83.0M | 731,774 | $161.7M | 1.7M | -986,204-57.40% | Reduce |
| Gotham Asset Management, LLC |
| 0.19% | 0.2% | #108 | $81.6M | 719,545 | $63.7M | 676,670 | +42,875+6.34% | Add |
| Pictet Asset Management Holding SA |
| 0.08% | 0.09% | #210 | $81.3M | 713,354 | $84.8M | 916,188 | -202,834-22.14% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #618 | $76.7M | 676,191 | $86.2M | 915,527 | -239,336-26.14% | Reduce |
| MACKENZIE FINANCIAL CORP |
| 0.07% | 0.06% | #223 | $72.0M | 634,862 | $51.7M | 549,633 | +85,229+15.51% | Add |
| CITIGROUP INC |
| 0.02% | 0.02% | #409 | $66.5M | 586,431 | $56.3M | 597,649 | -11,218-1.88% | Reduce |
