| BlackRock, Inc. |
| <0.01% | <0.01% | #71 | $32.3M | 8.8M | $41.3M | 5.4M | +3.4M+63.70% | Add |
| EcoR1 Capital, LLC |
| 1.17% | — | #1 | $24.0M | 6.5M | $0 | 0 | +6.5M | New Buy |
| TANG CAPITAL MANAGEMENT LLC |
| 1.08% | — | #3 | $23.9M | 6.5M | $0 | 0 | +6.5M | New Buy |
| Nantahala Capital Management, LLC |
| 0.67% | 0.86% | #5 | $20.0M | 5.5M | $23.4M | 3.1M | +2.4M+79.51% | Add |
| MONTANOVA CAPITAL, LLC |
| 0.25% | 1.29% | #10 | $13.5M | 3.7M | $50.3M | 6.6M | -2.9M-43.90% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #37 | $11.1M | 3.0M | $12.5M | 1.6M | +1.4M+87.55% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $10.8M | 2.9M | $10.4M | 1.4M | +1.6M+117.79% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $9.9M | 2.7M | $20.7M | 2.7M | +4,268+0.16% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #60 | $8.4M | 2.3M | $2.5M | 331,717 | +2.0M+589.05% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #83 | $7.5M | 2.0M | $11.9M | 1.5M | +487,174+31.43% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | <0.01% | #30 | $7.3M | 2.0M | $3.1M | 400,000 | +1.6M+400.00% | Add |
| GSK plc |
| 1.09% | 2.29% | #2 | $6.5M | 1.8M | $13.7M | 1.8M | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #34 | $6.4M | 1.7M | $7.5M | 974,739 | +773,728+79.38% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #32 | $6.0M | 1.6M | $104,312 | 13,600 | +1.6M+12,016.18% | Add |
| ADAR1 Capital Management, LLC |
| 0.26% | 0.06% | #9 | $5.7M | 1.6M | $1.0M | 130,560 | +1.4M+1,098.70% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #52 | $5.4M | 1.5M | $2.7M | 356,471 | +1.1M+316.81% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #78 | $5.2M | 1.4M | $11.4M | 1.5M | -54,409-3.66% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $5.2M | 1.4M | $2.6M | 335,036 | +1.1M+326.33% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #43 | $5.0M | 1.4M | $0 | 0 | +1.4M | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #64 | $4.6M | 1.3M | $2.4M | 315,185 | +938,724+297.83% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $4.0M | 1.1M | $4.2M | 543,165 | +560,096+103.12% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $4.0M | 1.1M | $4.4M | 571,909 | +522,516+91.36% | Add |
| Ikarian Capital, LLC |
| 0.41% | 0.65% | #7 | $3.8M | 1.0M | $8.0M | 1.0M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #81 | $3.8M | 1.0M | $970,708 | 126,559 | +916,470+724.14% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #40 | $3.8M | 1.0M | $5.6M | 727,315 | +311,482+42.83% | Add |
| Jump Financial, LLC |
| 0.03% | 0.04% | #20 | $3.7M | 1.0M | $2.8M | 369,805 | +635,195+171.76% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #62 | $3.5M | 960,547 | $8.7M | 1.1M | -169,734-15.02% | Reduce |
| Assenagon Asset Management S.A. |
| <0.01% | 0.01% | #44 | $3.1M | 835,204 | $9.2M | 1.2M | -358,669-30.04% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #49 | $3.0M | 812,766 | $1.1M | 139,000 | +673,766+484.72% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $2.9M | 782,144 | $4.6M | 599,379 | +182,765+30.49% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #38 | $2.7M | 745,317 | $5.7M | 736,684 | +8,633+1.17% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.02% | #46 | $2.5M | 692,372 | $16.7M | 2.2M | -1.5M-68.24% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.05% | 0.02% | #14 | $2.5M | 681,832 | $1.2M | 153,344 | +528,488+344.64% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #47 | $2.4M | 651,427 | $15.9M | 2.1M | -1.4M-68.60% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $1.8M | 487,869 | $3.6M | 472,985 | +14,884+3.15% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $1.6M | 433,220 | $3.3M | 426,869 | +6,351+1.49% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.15% | 0.33% | #12 | $1.4M | 391,900 | $3.2M | 419,949 | -28,049-6.68% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $1.3M | 345,648 | $2.5M | 329,884 | +15,764+4.78% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.03% | #26 | $1.1M | 303,988 | $2.3M | 303,988 | 00.00% | Unchanged |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #54 | $1.1M | 286,988 | $2.2M | 286,988 | 00.00% | Unchanged |
| Peapod Lane Capital LLC |
| 0.71% | — | #4 | $1.0M | 285,798 | $0 | 0 | +285,798 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #94 | $1.0M | 285,084 | $909,662 | 118,600 | +166,484+140.37% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #66 | $900,360 | 246,000 | $321,679 | 41,940 | +204,060+486.55% | Add |
| Engineers Gate Manager LP |
| 0.01% | 0.01% | #27 | $885,720 | 242,000 | $967,256 | 126,109 | +115,891+91.90% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | — | #22 | $855,895 | 233,851 | $0 | 0 | +233,851 | New Buy |
| EntryPoint Capital, LLC |
| 0.19% | 0.1% | #11 | $794,948 | 217,199 | $347,052 | 45,248 | +171,951+380.02% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #31 | $765,844 | 209,247 | $549,195 | 71,603 | +137,644+192.23% | Add |
| Quadrature Capital Ltd |
| 0.01% | — | #35 | $692,176 | 189,119 | $0 | 0 | +189,119 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $674,143 | 184,192 | $2.2M | 243,835 | -59,643-24.46% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #80 | $570,477 | 155,868 | $1.2M | 156,242 | -374-0.24% | Reduce |
