| RA CAPITAL MANAGEMENT, L.P. |
| 0.58% | 0.27% | #14 | $67.3M | 12.7M | $25.5M | 6.8M | +5.9M+86.99% | Add |
| BML Capital Management, LLC |
| 36.13% | 34.31% | #1 | $63.3M | 12.0M | $53.4M | 14.3M | -2.3M-15.96% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #66 | $53.1M | 10.0M | $27.8M | 7.4M | +2.6M+35.51% | Add |
| Deep Track Capital, LP |
| 0.72% | 0.57% | #13 | $49.4M | 9.3M | $35.0M | 9.3M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 3.23% | 2.08% | #4 | $35.4M | 6.7M | $25.0M | 6.7M | +27,971+0.42% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $30.8M | 5.8M | $19.4M | 5.2M | +650,397+12.59% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.57% | 0.48% | #15 | $26.1M | 4.9M | $18.5M | 4.9M | 00.00% | Unchanged |
| Rock Springs Capital Management LP |
| 1.12% | 0.99% | #8 | $22.9M | 4.3M | $16.8M | 4.5M | -142,118-3.18% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.02% | #26 | $21.5M | 4.1M | $14.5M | 3.9M | +200,000+5.17% | Add |
| Decheng Capital LLC |
| 2.92% | 2.29% | #5 | $21.4M | 4.0M | $15.2M | 4.0M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #74 | $17.2M | 3.3M | $7.5M | 2.0M | +1.2M+62.06% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $16.9M | 3.2M | $9.1M | 2.4M | +766,367+31.62% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $12.6M | 2.4M | $10.6M | 2.8M | -430,938-15.29% | Reduce |
| BRAIDWELL LP |
| 0.42% | 0.21% | #17 | $11.3M | 2.1M | $6.4M | 1.7M | +443,232+26.09% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #32 | $10.7M | 2.0M | $12.6M | 3.4M | -1.3M-39.80% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.07% | — | #9 | $10.3M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Kalehua Capital Management LLC |
| 6.95% | 4.86% | #2 | $9.7M | 1.8M | $6.9M | 1.8M | 00.00% | Unchanged |
| Jones Hill Capital LP |
| 1.98% | — | #6 | $9.3M | 1.8M | $0 | 0 | +1.8M | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $8.7M | 1.6M | $5.8M | 1.5M | +101,681+6.60% | Add |
| Palo Alto Investors LP |
| 1.25% | 0.93% | #7 | $8.5M | 1.6M | $6.1M | 1.6M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.03% | 0.02% | #27 | $8.5M | 1.6M | $5.6M | 1.5M | +125,431+8.44% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $7.8M | 1.5M | $6.2M | 1.7M | -190,331-11.49% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.02% | 0.01% | #28 | $7.2M | 1.4M | $1.9M | 502,290 | +853,862+169.99% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #33 | $6.4M | 1.2M | $5.3M | 1.4M | -208,474-14.70% | Reduce |
| MPM BioImpact LLC |
| 0.34% | 0.11% | #18 | $5.5M | 1.0M | $1.5M | 391,918 | +650,549+165.99% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #49 | $5.5M | 1.0M | $3.7M | 997,850 | +43,105+4.32% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $5.3M | 998,763 | $2.7M | 728,225 | +270,538+37.15% | Add |
| Aldebaran Capital, LLC |
| 3.73% | 2.72% | #3 | $5.0M | 936,731 | $3.6M | 947,162 | -10,431-1.10% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #58 | $4.8M | 907,173 | $2.4M | 628,859 | +278,314+44.26% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #40 | $4.3M | 817,531 | $1.9M | 502,631 | +314,900+62.65% | Add |
| Three Bridge Wealth Advisors, LLC |
| 0.95% | 0.74% | #10 | $3.8M | 714,823 | $2.7M | 714,823 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #87 | $3.2M | 609,158 | $2.2M | 588,691 | +20,467+3.48% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $2.8M | 523,895 | $2.8M | 756,127 | -232,232-30.71% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #93 | $2.7M | 517,049 | $2.3M | 600,430 | -83,381-13.89% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $2.7M | 513,840 | $1.9M | 511,461 | +2,379+0.47% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #102 | $2.4M | 468,964 | $1.7M | 486,633 | -17,669-3.63% | Reduce |
| Aisling Capital Management LP |
| 0.49% | 0.34% | #16 | $2.3M | 434,455 | $1.6M | 434,455 | 00.00% | Unchanged |
| Bollard Group LLC |
| 0.07% | 0.05% | #22 | $2.3M | 431,631 | $1.6M | 431,631 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.04% | — | #24 | $2.2M | 421,500 | $0 | 0 | +421,500 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #59 | $2.2M | 414,499 | $3.4M | 900,804 | -486,305-53.99% | Reduce |
| Tetragon Partners GP Ltd |
| 0.33% | — | #19 | $2.1M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #52 | $1.9M | 365,055 | $1.2M | 308,165 | +56,890+18.46% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $1.8M | 346,058 | $978,713 | 260,990 | +85,068+32.59% | Add |
| FMR LLC |
| <0.01% | <0.01% | #115 | $1.7M | 313,850 | $661,324 | 176,353 | +137,497+77.97% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #89 | $1.5M | 282,599 | $776,339 | 207,024 | +75,575+36.51% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #82 | $1.5M | 278,404 | $442,575 | 118,020 | +160,384+135.90% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #78 | $1.5M | 275,611 | $999,181 | 266,448 | +9,163+3.44% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #91 | $1.4M | 267,498 | $964,335 | 257,156 | +10,342+4.02% | Add |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.86% | 0.98% | #12 | $1.4M | 257,675 | $1.4M | 366,490 | -108,815-29.69% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #97 | $1.4M | 257,001 | $775,553 | 206,814 | +50,187+24.27% | Add |
