| BlackRock, Inc. |
| <0.01% | <0.01% | #97 | $134.8M | 25.6M | $24.2M | 6.8M | +18.7M+274.15% | Add |
| Deep Track Capital, LP |
| 1.11% | 0.69% | #6 | $76.0M | 14.4M | $42.5M | 12.0M | +2.4M+20.15% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $61.9M | 11.7M | $41.6M | 11.8M | -14,149-0.12% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #117 | $43.7M | 8.3M | $4.1M | 1.1M | +7.1M+624.17% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #98 | $36.5M | 6.9M | $8.9M | 2.5M | +4.4M+176.23% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.03% | #37 | $29.7M | 5.6M | $20.0M | 5.6M | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #88 | $23.3M | 4.4M | $26.3M | 7.4M | -3.0M-40.42% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #129 | $21.6M | 4.1M | $0 | 0 | +4.1M | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #127 | $20.3M | 3.8M | $0 | 0 | +3.8M | New Buy |
| Candriam S.C.A. |
| 0.07% | — | #33 | $16.0M | 3.0M | $0 | 0 | +3.0M | New Buy |
| Foresite Capital Management VI LLC |
| 2.26% | 2.12% | #3 | $14.5M | 2.8M | $9.7M | 2.8M | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #107 | $13.6M | 2.6M | $1.9M | 538,050 | +2.1M+381.21% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #109 | $13.3M | 2.5M | $1.9M | 538,688 | +2.0M+367.71% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #130 | $12.1M | 2.3M | $21.2M | 6.0M | -3.7M-61.66% | Reduce |
| RTW INVESTMENTS, LP |
| 0.09% | 0.07% | #23 | $10.5M | 2.0M | $7.1M | 2.0M | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #113 | $10.4M | 2.0M | $4.2M | 1.2M | +784,100+66.36% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #85 | $9.3M | 1.8M | $15.4M | 4.4M | -2.6M-59.43% | Reduce |
| Eagle Health Investments LP |
| 1.49% | 1.06% | #4 | $9.0M | 1.7M | $6.1M | 1.7M | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $8.3M | 1.6M | $4.4M | 1.3M | +319,565+25.43% | Add |
| Halter Ferguson Financial Inc. |
| 1.27% | — | #5 | $7.8M | 1.5M | $0 | 0 | +1.5M | New Buy |
| FIRST TRUST ADVISORS LP |
| <0.01% | — | #76 | $7.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #138 | $7.1M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #105 | $6.8M | 1.3M | $627,015 | 177,123 | +1.1M+631.28% | Add |
| Newtyn Management, LLC |
| 0.78% | 0.67% | #9 | $6.3M | 1.2M | $6.3M | 1.8M | -593,895-33.33% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #154 | $5.4M | 1.0M | $2.1M | 600,905 | +425,195+70.76% | Add |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.07% | 0.07% | #30 | $5.0M | 952,380 | $3.4M | 952,380 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.22% | 0.19% | #14 | $4.8M | 913,242 | $3.2M | 913,242 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #135 | $4.7M | 891,983 | $161,457 | 45,609 | +846,374+1,855.72% | Add |
| AdvisorShares Investments LLC |
| 0.56% | 0.37% | #10 | $4.7M | 882,892 | $2.0M | 567,587 | +315,305+55.55% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | 0.01% | #86 | $4.3M | 822,471 | $7.0M | 2.0M | -1.2M-58.37% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.08% | 0.02% | #28 | $4.2M | 797,500 | $1.2M | 347,000 | +450,500+129.83% | Add |
| GROUP ONE TRADING LLC |
| 0.01% | 0.01% | #71 | $4.1M | 783,600 | $3.3M | 937,700 | -154,100-16.43% | Reduce |
| Woodline Partners LP |
| 0.01% | 0.01% | #58 | $3.2M | 600,000 | $2.1M | 600,000 | 00.00% | Unchanged |
| JGP Global Gestao de Recursos Ltda. |
| 5.8% | — | #1 | $2.6M | 500,000 | $0 | 0 | +500,000 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #186 | $2.6M | 490,433 | $2.9M | 819,664 | -329,231-40.17% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #153 | $2.6M | 490,135 | $941,640 | 266,000 | +224,135+84.26% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| <0.01% | <0.01% | #110 | $2.6M | 489,613 | $2.0M | 567,576 | -77,963-13.74% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.03% | 0.03% | #39 | $2.5M | 483,952 | $2.0M | 567,576 | -83,624-14.73% | Reduce |
| Swiss National Bank |
| <0.01% | <0.01% | #116 | $2.5M | 473,700 | $1.2M | 325,900 | +147,800+45.35% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #106 | $2.1M | 399,436 | $0 | 0 | +399,436 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #123 | $1.9M | 367,200 | $1.5M | 426,700 | -59,500-13.94% | Reduce |
| Man Group plc |
| <0.01% | <0.01% | #87 | $1.9M | 358,812 | $1.9M | 543,515 | -184,703-33.98% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #148 | $1.8M | 345,042 | $24,465 | 6,911 | +338,131+4,892.65% | Add |
| BIT Capital GmbH |
| 0.05% | 0.03% | #36 | $1.7M | 320,576 | $646,319 | 182,576 | +138,000+75.58% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | — | #112 | $1.6M | 304,576 | $0 | 0 | +304,576 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #174 | $1.6M | 297,918 | $23,134 | 6,535 | +291,383+4,458.81% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #208 | $1.5M | 273,350 | $654,547 | 192,514 | +80,836+41.99% | Add |
| Jefferies Financial Group Inc. |
| 0.01% | 0.01% | #59 | $1.5M | 275,900 | $976,686 | 275,900 | 00.00% | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | — | #118 | $1.4M | 264,382 | $0 | 0 | +264,382 | New Buy |
| Warm Springs Advisors Inc. |
| 0.96% | 0.41% | #8 | $1.4M | 263,000 | $482,856 | 136,400 | +126,600+92.82% | Add |
