| FMR LLC |
| <0.01% | <0.01% | #52 | $57.4M | 3.9M | $5.2M | 322,600 | +3.6M+1,122.06% | Add |
| Vivo Capital, LLC |
| 3.32% | 0.28% | #2 | $36.4M | 2.5M | $3.3M | 208,333 | +2.3M+1,100.00% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $25.1M | 1.7M | $271,462 | 16,977 | +1.7M+10,078.41% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.37% | 0.45% | #11 | $24.7M | 1.7M | $23.2M | 1.4M | +252,218+17.42% | Add |
| Ikarian Capital, LLC |
| 1.82% | 1.47% | #3 | $17.1M | 1.2M | $18.1M | 1.1M | +45,300+4.00% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #75 | $16.7M | 1.1M | $4.2M | 263,421 | +883,700+335.47% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #56 | $13.0M | 895,461 | $2.4M | 152,516 | +742,945+487.13% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $12.7M | 876,230 | $8.5M | 533,889 | +342,341+64.12% | Add |
| Candriam S.C.A. |
| 0.05% | — | #24 | $10.9M | 749,588 | $0 | 0 | +749,588 | New Buy |
| Caption Management, LLC |
| 0.05% | — | #25 | $10.5M | 721,700 | $0 | 0 | +721,700 | New Buy |
| RTW INVESTMENTS, LP |
| 0.09% | 0.06% | #22 | $10.1M | 696,570 | $5.9M | 370,246 | +326,324+88.14% | Add |
| Stonepine Capital Management, LLC |
| 1.47% | 6.24% | #5 | $9.6M | 660,000 | $15.6M | 975,200 | -315,200-32.32% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #72 | $9.3M | 639,537 | $1.1M | 69,160 | +570,377+824.72% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #65 | $9.0M | 621,164 | $463,342 | 28,977 | +592,187+2,043.64% | Add |
| Velan Capital Investment Management LP |
| 5.48% | 5.84% | #1 | $9.0M | 618,685 | $9.3M | 583,333 | +35,352+6.06% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #61 | $8.8M | 607,660 | $47.2M | 3.0M | -2.3M-79.41% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #39 | $8.5M | 585,578 | $5.6M | 352,572 | +233,006+66.09% | Add |
| BRAIDWELL LP |
| 0.31% | — | #12 | $8.5M | 584,412 | $0 | 0 | +584,412 | New Buy |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #36 | $8.1M | 556,761 | $8.5M | 533,965 | +22,796+4.27% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #35 | $7.9M | 540,126 | $8.6M | 540,126 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.02% | 0.02% | #28 | $7.7M | 531,254 | $5.2M | 323,911 | +207,343+64.01% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $7.4M | 510,814 | $463,550 | 28,990 | +481,824+1,662.04% | Add |
| Sofinnova Investments, Inc. |
| 0.38% | 0.06% | #10 | $7.3M | 500,039 | $1.7M | 104,400 | +395,639+378.96% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #51 | $6.6M | 451,226 | $0 | 0 | +451,226 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #80 | $6.3M | 432,220 | $1.4M | 178,329 | +253,891+142.37% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #41 | $6.3M | 429,893 | $452,277 | 28,285 | +401,608+1,419.86% | Add |
| Siren, L.L.C. |
| 0.13% | 0.19% | #18 | $6.2M | 427,141 | $6.8M | 427,141 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #70 | $6.1M | 422,556 | $537,712 | 33,628 | +388,928+1,156.56% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.08% | #23 | $6.1M | 422,187 | $6.4M | 399,891 | +22,296+5.58% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #45 | $5.1M | 353,390 | $1.1M | 68,588 | +284,802+415.24% | Add |
| BVF INC/IL |
| 0.13% | 0.17% | #17 | $4.9M | 339,549 | $5.4M | 339,549 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | — | #64 | $4.7M | 325,296 | $0 | 0 | +325,296 | New Buy |
| Trexquant Investment LP |
| 0.03% | 0.01% | #26 | $4.7M | 321,604 | $810,885 | 50,712 | +270,892+534.18% | Add |
| DIADEMA PARTNERS LP |
| 0.55% | 0.49% | #7 | $4.5M | 307,000 | $2.9M | 179,738 | +127,262+70.80% | Add |
| Logos Global Management LP |
| 0.19% | 0.5% | #14 | $4.4M | 300,000 | $10.0M | 625,000 | -325,000-52.00% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #76 | $4.0M | 274,946 | $509,345 | 31,854 | +243,092+763.14% | Add |
| Avidity Partners Management LP |
| 0.62% | 0.7% | #6 | $3.9M | 265,934 | $3.5M | 215,934 | +50,000+23.16% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #66 | $3.7M | 253,518 | $1.0M | 62,786 | +190,732+303.78% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.47% | 0.35% | #9 | $3.6M | 247,800 | $2.2M | 136,015 | +111,785+82.19% | Add |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.2% | #16 | $3.2M | 220,462 | $3.4M | 213,462 | +7,000+3.28% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #78 | $2.9M | 199,134 | $192,664 | 12,049 | +187,085+1,552.70% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #47 | $2.8M | 194,000 | $3.1M | 194,616 | -616-0.32% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.02% | — | #32 | $2.7M | 184,501 | $0 | 0 | +184,501 | New Buy |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #44 | $2.6M | 176,889 | $0 | 0 | +176,889 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #95 | $2.5M | 168,841 | $0 | 0 | +168,841 | New Buy |
| Integral Health Asset Management, LLC |
| 0.1% | 0.13% | #21 | $2.4M | 167,000 | $2.7M | 167,000 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #49 | $2.4M | 164,000 | $2.4M | 152,600 | +11,400+7.47% | Add |
| Nuveen, LLC |
| <0.01% | — | #67 | $2.3M | 161,187 | $0 | 0 | +161,187 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #71 | $2.3M | 157,042 | $534,546 | 33,430 | +123,612+369.76% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | — | #38 | $2.3M | 156,062 | $0 | 0 | +156,062 | New Buy |
