| RA CAPITAL MANAGEMENT, L.P. |
| 2.49% | — | #3 | $286.8M | 7.8M | $0 | 0 | +7.8M | New Buy |
| Novo Holdings A/S |
| 8.94% | — | #1 | $153.6M | 4.2M | $0 | 0 | +4.2M | New Buy |
| FMR LLC |
| 0.01% | — | #27 | $135.8M | 3.7M | $0 | 0 | +3.7M | New Buy |
| Capital International Investors |
| 0.03% | — | #20 | $132.4M | 3.6M | $0 | 0 | +3.6M | New Buy |
| Deep Track Capital, LP |
| 1.93% | — | #4 | $132.3M | 3.6M | $0 | 0 | +3.6M | New Buy |
| Siren, L.L.C. |
| 1.55% | — | #5 | $76.6M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Avoro Capital Advisors LLC |
| 0.63% | — | #7 | $70.7M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Bain Capital Life Sciences Investors, LLC |
| 3.6% | — | #2 | $60.6M | 1.7M | $0 | 0 | +1.7M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #32 | $42.3M | 1.2M | $0 | 0 | +1.2M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #38 | $28.7M | 780,758 | $0 | 0 | +780,758 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #30 | $27.4M | 746,040 | $0 | 0 | +746,040 | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.15% | — | #13 | $26.3M | 715,791 | $0 | 0 | +715,791 | New Buy |
| Rock Springs Capital Management LP |
| 1.03% | — | #6 | $21.1M | 575,432 | $0 | 0 | +575,432 | New Buy |
| Bellevue Group AG |
| 0.43% | — | #8 | $20.2M | 550,000 | $0 | 0 | +550,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #33 | $19.2M | 523,450 | $0 | 0 | +523,450 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #46 | $10.4M | 283,833 | $0 | 0 | +283,833 | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.11% | — | #14 | $10.1M | 275,000 | $0 | 0 | +275,000 | New Buy |
| ExodusPoint Capital Management, LP |
| 0.05% | — | #16 | $8.0M | 218,287 | $0 | 0 | +218,287 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #42 | $7.8M | 211,798 | $0 | 0 | +211,798 | New Buy |
| BRAIDWELL LP |
| 0.22% | — | #10 | $5.9M | 160,000 | $0 | 0 | +160,000 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #28 | $5.7M | 154,674 | $0 | 0 | +154,674 | New Buy |
| Woodline Partners LP |
| 0.02% | — | #21 | $5.5M | 150,040 | $0 | 0 | +150,040 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.23% | — | #9 | $5.1M | 138,030 | $0 | 0 | +138,030 | New Buy |
| Ensign Peak Advisors, Inc |
| 0.01% | — | #26 | $4.2M | 115,394 | $0 | 0 | +115,394 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #37 | $4.1M | 112,499 | $0 | 0 | +112,499 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #41 | $4.0M | 108,236 | $0 | 0 | +108,236 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #39 | $3.0M | 81,928 | $0 | 0 | +81,928 | New Buy |
| Burkehill Global Management, LP |
| 0.1% | — | #15 | $2.8M | 75,000 | $0 | 0 | +75,000 | New Buy |
| Aberdeen Group plc |
| <0.01% | — | #31 | $1.9M | 52,117 | $0 | 0 | +52,117 | New Buy |
| Opaleye Management Inc. |
| 0.16% | — | #12 | $1.8M | 47,652 | $0 | 0 | +47,652 | New Buy |
| UBS Group AG |
| <0.01% | — | #44 | $1.7M | 47,351 | $0 | 0 | +47,351 | New Buy |
| Parkman Healthcare Partners LLC |
| 0.17% | — | #11 | $1.7M | 45,000 | $0 | 0 | +45,000 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #45 | $1.5M | 40,487 | $0 | 0 | +40,487 | New Buy |
| Ghisallo Capital Management LLC |
| 0.01% | — | #23 | $1.5M | 40,000 | $0 | 0 | +40,000 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #36 | $1.2M | 33,098 | $0 | 0 | +33,098 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.04% | — | #17 | $1.1M | 30,000 | $0 | 0 | +30,000 | New Buy |
| SOROS FUND MANAGEMENT LLC |
| 0.01% | — | #22 | $918,250 | 25,000 | $0 | 0 | +25,000 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #40 | $687,586 | 18,720 | $0 | 0 | +18,720 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #18 | $648,689 | 17,661 | $0 | 0 | +17,661 | New Buy |
| XTX Topco Ltd |
| 0.01% | — | #24 | $638,698 | 17,389 | $0 | 0 | +17,389 | New Buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.03% | — | #19 | $484,211 | 13,183 | $0 | 0 | +13,183 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | — | #35 | $448,179 | 12,202 | $0 | 0 | +12,202 | New Buy |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #34 | $397,160 | 10,813 | $0 | 0 | +10,813 | New Buy |
| Weiss Asset Management LP |
| <0.01% | — | #29 | $367,300 | 10,000 | $0 | 0 | +10,000 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $300,047 | 8,169 | $0 | 0 | +8,169 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | — | #48 | $279,736 | 7,616 | $0 | 0 | +7,616 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #43 | $229,636 | 6,252 | $0 | 0 | +6,252 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #47 | $208,626 | 5,680 | $0 | 0 | +5,680 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #51 | $149,785 | 4,078 | $0 | 0 | +4,078 | New Buy |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #25 | $132,228 | 3,600 | $0 | 0 | +3,600 | New Buy |
