| HRTG GPE, LLC |
| 16.26% | — | #1 | $403.5M | 16.9M | $0 | 0 | +16.9M | New Buy |
| FMR LLC |
| 0.01% | — | #27 | $212.5M | 8.9M | $0 | 0 | +8.9M | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 2.94% | — | #2 | $195.6M | 8.2M | $0 | 0 | +8.2M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.07% | — | #16 | $100.3M | 4.2M | $0 | 0 | +4.2M | New Buy |
| Capital Research Global Investors |
| 0.01% | — | #25 | $85.8M | 3.6M | $0 | 0 | +3.6M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #36 | $46.4M | 1.8M | $0 | 0 | +1.8M | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #24 | $36.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Liberty Mutual Group Asset Management Inc. |
| 2.49% | — | #3 | $28.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| JENNISON ASSOCIATES LLC |
| 0.01% | — | #23 | $21.6M | 903,575 | $0 | 0 | +903,575 | New Buy |
| Paradigm Biocapital Advisors LP |
| 0.4% | — | #6 | $21.5M | 900,000 | $0 | 0 | +900,000 | New Buy |
| Jupiter Topco LLC |
| 0.01% | — | #28 | $17.7M | 749,703 | $0 | 0 | +749,703 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #40 | $15.7M | 658,787 | $0 | 0 | +658,787 | New Buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #31 | $15.5M | 650,000 | $0 | 0 | +650,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #42 | $15.4M | 644,969 | $0 | 0 | +644,969 | New Buy |
| Deep Track Capital, LP |
| 0.21% | — | #10 | $14.3M | 600,000 | $0 | 0 | +600,000 | New Buy |
| Woodline Partners LP |
| 0.03% | — | #19 | $9.9M | 413,980 | $0 | 0 | +413,980 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #37 | $9.5M | 400,021 | $0 | 0 | +400,021 | New Buy |
| MONTANOVA CAPITAL, LLC |
| 0.17% | — | #14 | $9.5M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #41 | $9.0M | 377,758 | $0 | 0 | +377,758 | New Buy |
| Catalio Capital Management, LP |
| 1.4% | — | #5 | $7.5M | 312,500 | $0 | 0 | +312,500 | New Buy |
| PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | — | #34 | $7.2M | 300,000 | $0 | 0 | +300,000 | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.1% | — | #15 | $7.2M | 300,000 | $0 | 0 | +300,000 | New Buy |
| BRAIDWELL LP |
| 0.26% | — | #8 | $7.2M | 300,000 | $0 | 0 | +300,000 | New Buy |
| UBS Group AG |
| <0.01% | — | #48 | $6.4M | 267,760 | $0 | 0 | +267,760 | New Buy |
| PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.18% | — | #13 | $5.5M | 229,776 | $0 | 0 | +229,776 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #39 | $5.3M | 223,065 | $0 | 0 | +223,065 | New Buy |
| Integral Health Asset Management, LLC |
| 0.19% | — | #12 | $4.8M | 200,000 | $0 | 0 | +200,000 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.19% | — | #11 | $4.8M | 200,000 | $0 | 0 | +200,000 | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | — | #20 | $4.8M | 199,612 | $0 | 0 | +199,612 | New Buy |
| HRT FINANCIAL LP |
| 0.01% | — | #30 | $3.7M | 156,242 | $0 | 0 | +156,242 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #49 | $3.6M | 149,474 | $0 | 0 | +149,474 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #62 | $3.1M | 130,826 | $0 | 0 | +130,826 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #52 | $2.9M | 120,000 | $0 | 0 | +120,000 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #56 | $2.6M | 109,849 | $0 | 0 | +109,849 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #50 | $2.4M | 102,521 | $0 | 0 | +102,521 | New Buy |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #35 | $1.8M | 74,233 | $0 | 0 | +74,233 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #43 | $1.6M | 66,821 | $0 | 0 | +66,821 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #60 | $1.6M | 65,388 | $0 | 0 | +65,388 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | — | #45 | $1.3M | 55,814 | $0 | 0 | +55,814 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #61 | $1.3M | 53,782 | $0 | 0 | +53,782 | New Buy |
| Casdin Capital, LLC |
| 0.06% | — | #17 | $1.2M | 50,000 | $0 | 0 | +50,000 | New Buy |
| Ghisallo Capital Management LLC |
| 0.01% | — | #29 | $1.2M | 50,000 | $0 | 0 | +50,000 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #63 | $1.1M | 44,482 | $0 | 0 | +44,482 | New Buy |
| Monashee Investment Management LLC |
| 1.71% | — | #4 | $1.0M | 42,693 | $0 | 0 | +42,693 | New Buy |
| SEI INVESTMENTS CO |
| <0.01% | — | #47 | $957,005 | 40,126 | $0 | 0 | +40,126 | New Buy |
| Shay Capital LLC |
| 0.06% | — | #18 | $918,225 | 38,500 | $0 | 0 | +38,500 | New Buy |
| Alyeska Investment Group, L.P. |
| <0.01% | — | #38 | $715,500 | 30,000 | $0 | 0 | +30,000 | New Buy |
| Burkehill Global Management, LP |
| 0.03% | — | #21 | $715,500 | 30,000 | $0 | 0 | +30,000 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #59 | $472,254 | 19,801 | $0 | 0 | +19,801 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | — | #44 | $452,196 | 18,960 | $0 | 0 | +18,960 | New Buy |
