| L1 Capital Pty Ltd |
| 2.58% | 1.7% | #3 | $76.7M | 7.8M | $43.2M | 7.8M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #52 | $67.7M | 6.9M | $16.1M | 2.9M | +4.0M+136.72% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $56.8M | 5.8M | $27.1M | 4.9M | +882,060+18.04% | Add |
| Sio Capital Management, LLC |
| 9.04% | 4.28% | #1 | $54.6M | 5.5M | $29.9M | 5.4M | +163,019+3.03% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.51% | 0.37% | #8 | $33.7M | 3.4M | $19.0M | 3.4M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 1.11% | 1.13% | #6 | $33.3M | 3.4M | $30.7M | 5.5M | -2.1M-38.83% | Reduce |
| ADAR1 Capital Management, LLC |
| 1.43% | 1.24% | #5 | $31.0M | 3.1M | $21.0M | 3.8M | -644,036-17.00% | Reduce |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.26% | 0.18% | #12 | $29.6M | 3.0M | $16.7M | 3.0M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.76% | 0.53% | #7 | $29.6M | 3.0M | $16.7M | 3.0M | 00.00% | Unchanged |
| Ensign Peak Advisors, Inc |
| 0.04% | 0.02% | #26 | $23.5M | 2.4M | $11.6M | 2.1M | +303,089+14.52% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $20.7M | 2.1M | $10.2M | 1.8M | +261,073+14.18% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #76 | $16.8M | 1.7M | $6.8M | 1.2M | +486,091+39.74% | Add |
| Rhenman & Partners Asset Management AB |
| 1.43% | 0.99% | #4 | $15.2M | 1.5M | $8.0M | 1.4M | +100,000+6.95% | Add |
| Vestal Point Capital, LP |
| 0.23% | 0.18% | #13 | $9.9M | 1.0M | $6.4M | 1.1M | -134,780-11.77% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.41% | 0.26% | #9 | $9.0M | 912,397 | $5.1M | 912,397 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $8.7M | 879,780 | $4.8M | 857,803 | +21,977+2.56% | Add |
| MONTANOVA CAPITAL, LLC |
| 0.15% | 0.12% | #16 | $8.4M | 850,000 | $4.7M | 850,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #69 | $7.4M | 752,168 | $7.8M | 1.4M | -654,668-46.53% | Reduce |
| Velan Capital Investment Management LP |
| 4.2% | 2.43% | #2 | $6.9M | 700,000 | $3.9M | 700,000 | 00.00% | Unchanged |
| Militia Capital Management LLC |
| 0.2% | 0.34% | #14 | $6.6M | 670,000 | $3.4M | 605,000 | +65,000+10.74% | Add |
| Assenagon Asset Management S.A. |
| 0.01% | — | #41 | $6.3M | 644,668 | $0 | 0 | +644,668 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $6.3M | 638,044 | $159,957 | 28,821 | +609,223+2,113.82% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $6.3M | 636,088 | $3.3M | 591,046 | +45,042+7.62% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $5.4M | 548,336 | $2.6M | 469,583 | +78,753+16.77% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $4.4M | 451,051 | $2.6M | 476,344 | -25,293-5.31% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $3.7M | 380,030 | $2.3M | 415,493 | -35,463-8.54% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #45 | $3.5M | 352,500 | $0 | 0 | +352,500 | New Buy |
| FEDERATED HERMES, INC. |
| <0.01% | — | #44 | $3.4M | 341,541 | $0 | 0 | +341,541 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #49 | $3.2M | 322,634 | $0 | 0 | +322,634 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #96 | $3.2M | 324,034 | $165,631 | 32,413 | +291,621+899.70% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #83 | $2.5M | 252,154 | $1.3M | 227,910 | +24,244+10.64% | Add |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #53 | $2.4M | 244,715 | $73,177 | 13,185 | +231,530+1,756.01% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #80 | $2.3M | 232,666 | $947,125 | 170,653 | +62,013+36.34% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #99 | $2.1M | 209,892 | $224,897 | 40,522 | +169,370+417.97% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #110 | $1.9M | 193,621 | $381,590 | 68,755 | +124,866+181.61% | Add |
| Holocene Advisors, LP |
| <0.01% | — | #47 | $1.8M | 178,884 | $0 | 0 | +178,884 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #78 | $1.7M | 173,158 | $1.7M | 307,864 | -134,706-43.76% | Reduce |
| Ikarian Capital, LLC |
| 0.17% | 0.17% | #15 | $1.6M | 166,571 | $2.0M | 366,571 | -200,000-54.56% | Reduce |
| Eversept Partners, LP |
| 0.08% | 0.12% | #21 | $1.6M | 166,229 | $2.2M | 401,187 | -234,958-58.57% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #111 | $1.5M | 156,019 | $1.9M | 336,980 | -180,961-53.70% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| <0.01% | — | #46 | $1.3M | 128,257 | $0 | 0 | +128,257 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $1.2M | 124,358 | $331,237 | 73,608 | +50,750+68.95% | Add |
| Symmetry Investments LP |
| 0.08% | 0.11% | #23 | $1.2M | 119,600 | $1.0M | 182,837 | -63,237-34.59% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #32 | $1.2M | 117,446 | $368,104 | 66,325 | +51,121+77.08% | Add |
| AWM Investment Company, Inc. |
| 0.1% | 0.07% | #19 | $1.1M | 115,000 | $638,250 | 115,000 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #92 | $1.1M | 108,289 | $610,067 | 109,922 | -1,633-1.49% | Reduce |
| BEARING POINT CAPITAL, LLC |
| 0.14% | 0.09% | #17 | $1.0M | 102,060 | $563,658 | 101,560 | +500+0.49% | Add |
| Empower Advisory Group, LLC |
| <0.01% | <0.01% | #55 | $995,658 | 101,082 | $561,005 | 101,082 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #72 | $963,873 | 97,856 | $328,459 | 59,183 | +38,673+65.34% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $955,766 | 97,032 | $392,794 | 70,774 | +26,258+37.10% | Add |
