| Opaleye Management Inc. |
| 9.38% | 9.3% | #1 | $103.5M | 2.9M | $70.6M | 2.9M | 00.00% | Unchanged |
| EcoR1 Capital, LLC |
| 3.82% | 2.27% | #3 | $78.6M | 2.2M | $53.6M | 2.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #84 | $68.6M | 1.9M | $42.4M | 1.7M | +178,547+10.40% | Add |
| Nantahala Capital Management, LLC |
| 1.42% | 1.07% | #9 | $42.6M | 1.2M | $29.0M | 1.2M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $35.4M | 976,570 | $24.5M | 994,089 | -17,519-1.76% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #76 | $27.8M | 767,972 | $12.7M | 586,046 | +181,926+31.04% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #92 | $25.4M | 701,786 | $13.1M | 530,215 | +171,571+32.36% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #80 | $23.6M | 652,303 | $14.3M | 577,666 | +74,637+12.92% | Add |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.38% | 0.32% | #14 | $18.2M | 501,600 | $10.8M | 439,300 | +62,300+14.18% | Add |
| National Philanthropic Trust |
| 0.26% | 0.06% | #18 | $17.8M | 492,112 | $2.2M | 492,112 | 00.00% | Unchanged |
| Westside Investment Management, Inc. |
| 2.05% | 1.77% | #7 | $15.6M | 431,160 | $11.5M | 467,915 | -36,755-7.86% | Reduce |
| Pillsbury Lake Capital LLC |
| 3.8% | 4.07% | #4 | $14.0M | 387,157 | $9.0M | 364,954 | +22,203+6.08% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #58 | $13.6M | 375,707 | $1.4M | 57,950 | +317,757+548.33% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #52 | $11.7M | 322,466 | $7.5M | 302,108 | +20,358+6.74% | Add |
| Woodline Partners LP |
| 0.03% | 0.02% | #32 | $11.3M | 310,879 | $4.2M | 170,699 | +140,180+82.12% | Add |
| THOMPSON SIEGEL & WALMSLEY LLC |
| 0.19% | 0.18% | #22 | $10.8M | 297,232 | $10.0M | 406,089 | -108,857-26.81% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #82 | $9.3M | 255,849 | $5.9M | 237,832 | +18,017+7.58% | Add |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #48 | $9.0M | 249,182 | $2.0M | 82,721 | +166,461+201.23% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #96 | $8.0M | 219,897 | $3.3M | 133,520 | +86,377+64.69% | Add |
| Panoramic Capital, LLC |
| 3.24% | 3.21% | #5 | $7.5M | 208,192 | $4.6M | 185,000 | +23,192+12.54% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #115 | $7.0M | 194,591 | $3.7M | 151,748 | +42,843+28.23% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #108 | $7.0M | 191,635 | $3.8M | 169,876 | +21,759+12.81% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #57 | $6.8M | 188,452 | $0 | 0 | +188,452 | New Buy |
| Lumbard & Kellner, LLC |
| 1.93% | 1.5% | #8 | $6.4M | 175,909 | $4.3M | 175,911 | -2-0.00% | Reduce |
| CANNELL CAPITAL LLC |
| 4.14% | 5.32% | #2 | $6.2M | 170,747 | $8.4M | 341,985 | -171,238-50.07% | Reduce |
| NORGES BANK |
| <0.01% | — | #100 | $6.1M | 169,500 | $0 | 0 | +169,500 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #79 | $6.1M | 168,539 | $4.1M | 164,715 | +3,824+2.32% | Add |
| Informed Momentum Co LLC |
| 0.51% | 0.14% | #13 | $5.7M | 158,045 | $1.2M | 48,623 | +109,422+225.04% | Add |
| Prospect Capital Advisors, LLC |
| 2.58% | — | #6 | $5.7M | 157,200 | $0 | 0 | +157,200 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #106 | $5.3M | 147,205 | $4.4M | 179,784 | -32,579-18.12% | Reduce |
| Aristides Capital LLC |
| 1.04% | 1.01% | #10 | $5.3M | 145,410 | $4.6M | 186,041 | -40,631-21.84% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $5.1M | 142,257 | $3.6M | 144,367 | -2,110-1.46% | Reduce |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.34% | 0.36% | #15 | $5.0M | 137,572 | $4.7M | 188,802 | -51,230-27.13% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #105 | $4.8M | 132,583 | $5.4M | 217,446 | -84,863-39.03% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #94 | $4.3M | 118,249 | $2.7M | 111,255 | +6,994+6.29% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #61 | $4.2M | 116,291 | $2.6M | 106,393 | +9,898+9.30% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #95 | $4.2M | 114,655 | $235,917 | 9,559 | +105,096+1,099.45% | Add |
| WASATCH ADVISORS LP |
| 0.02% | — | #39 | $3.4M | 92,742 | $0 | 0 | +92,742 | New Buy |
| Bridge City Capital, LLC |
| 0.73% | 0.14% | #12 | $3.2M | 88,132 | $521,982 | 21,150 | +66,982+316.70% | Add |
| Walleye Capital LLC |
| 0.01% | 0.01% | #43 | $3.1M | 86,249 | $2.0M | 81,963 | +4,286+5.23% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #111 | $3.1M | 85,369 | $3.7M | 151,715 | -66,346-43.73% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #110 | $2.8M | 77,032 | $1.7M | 68,795 | +8,237+11.97% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #103 | $2.8M | 76,103 | $1.7M | 70,124 | +5,979+8.53% | Add |
| Diametric Capital, LP |
| 0.28% | 1.01% | #16 | $2.6M | 73,101 | $3.9M | 156,926 | -83,825-53.42% | Reduce |
| Numerai GP LLC |
| 0.21% | 0.09% | #20 | $2.5M | 70,114 | $921,946 | 37,356 | +32,758+87.69% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #116 | $2.4M | 65,424 | $4.2M | 168,958 | -103,534-61.28% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #67 | $2.2M | 59,562 | $0 | 0 | +59,562 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.02% | #35 | $2.1M | 57,516 | $1.4M | 55,605 | +1,911+3.44% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #109 | $2.0M | 56,181 | $1.2M | 49,374 | +6,807+13.79% | Add |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #71 | $1.9M | 52,907 | $454,680 | 18,423 | +34,484+187.18% | Add |
